Thinking inside the box: teasing out key interactions that drive PFAS distribution, accumulation, and effects through toxicokinetic modeling

Accumulating knowledge on the fate, bioaccumulation, and effects of per- and polyfluoroalkyl substances (PFAS) points to specific molecular interactions associated with the adverse impacts on human and wildlife health. Numerous papers have investigated PFAS interactions with specific proteins and their partitioning to phospholipids. What strategies can we use to organize this information and extract the signal from the noise? In this talk, Dr. Ng will discuss what we have (and haven't) been able to explain by integrating molecular insights into mechanistic toxicokinetic models, and discuss continuing challenges in addressing this diverse class of ubiquitous environmental contaminants.

THIS IS A HYBRID SEMINAR: LIVE IN-PERSON & VIA ZOOM:
-IN-PERSON: Love Auditorium, Levine Science Research Center B Room 101 (LSRC B101). Masks are required.
-ZOOM: Must register for link: https://duke.zoom.us/meeting/register/tJAuceqtpz8qHd2ymSuqpTjyQ9iwZvySLN3M
-Both attendance options are free and open to all.