Skip to main content
Browse by:
GROUP

UPGG Tuesday Seminar Series: "Knockout mice reveal an essential role for Epithelial splicing regulatory proteins (Esrps) in mammalian development and epithelial cell functions."

Event Image
Tuesday, December 02, 2014
12:30 pm - 1:30 pm
Russ P. Carstens, PhD.,University of Pennsylvania School of Medicine

Dr. Carstens' lab discovered the Epithelial Splicing Regulatory Proteins 1 and 2 (Esrp1 and Esrp2) in a screen for regulators of Fibroblast growth factor receptor 2 (Fgfr2) splicing. Subsequent studies have determined that the Esrps regulate an extensive genome-wide program of epithelial cell type-specific splicing. To further define the role of the Esrps in epithelial cell differentiation and function we developed mice with knockout alleles for Esrp1 and/or Esrp2. These mice have revealed an essential role for the Esrps in the development and function of diverse epithelial cell populations in mammals.

Contact: Carolyn Weinbaum