UPGG Tuesday Seminar Series: "Knockout mice reveal an essential role for Epithelial splicing regulatory proteins (Esrps) in mammalian development and epithelial cell functions."
Sponsor(s): University Program in Genetics & Genomics (UPGG)
Dr. Carstens' lab discovered the Epithelial Splicing Regulatory Proteins 1 and 2 (Esrp1 and Esrp2) in a screen for regulators of Fibroblast growth factor receptor 2 (Fgfr2) splicing. Subsequent studies have determined that the Esrps regulate an extensive genome-wide program of epithelial cell type-specific splicing. To further define the role of the Esrps in epithelial cell differentiation and function we developed mice with knockout alleles for Esrp1 and/or Esrp2. These mice have revealed an essential role for the Esrps in the development and function of diverse epithelial cell populations in mammals.
Contact: Carolyn Weinbaum