"Potential Role of Extracellular Tau in Development and Spread of Tauopathy: Effects of Anti-Tau Antibodies"

Dr. Holtzman's research seeks to understand the basic mechanisms underlying acute and chronic cell dysfunction in the central nervous system particularly as these mechanisms relate to Alzheimer's disease and injury to the developing brain. His research was instrumental in showing how dangerous amounts of a protein fragment called amyloid beta begin to accumulate in the brain many years before Alzheimer's disease symptoms arise. Dr. Holtzman is a member of the Institute of Medicine of the National Academy of Sciences.