"Development and reprogramming of neuronal diversity in the neocortex"

The genetic programs that control the differentiation of distinct types of neurons in the brain are still largely unknown. Dr. Arlotta examines the mammalian cerebral cortex to investigate the molecular pathways that direct the early specification of progenitors to generate distinct types of projection neurons during development. She specifically focus on the early signals that induce differentiation of corticospinal neurons, a clinically relevant neuronal target population that in humans selectively degenerates in ALS (Lou Gehrig's disease), Hereditary Spastic Paraplegia (HSP), Primary Lateral Sclerosis (PLS), and that is permanently injured in spinal cord injury.