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A multi-organism approach to understanding the metabolic basis for sex, reproduction, and disease

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Monday, January 23, 2017
1:15 pm - 2:15 pm
Matt Sieber, Carnegie Institute

Matt Sieber, Ph.D., Carnegie Institute.
Dr. Sieber uses multidisciplinary approaches like genetics, systems-based approaches (RNA seq., metabolomics, and proteomics), and biochemistry to examine the processes that facilitate mitochondrial remodeling and mitochondrial respiratory quiescence. He did his postdoctoral research in the laboratory of Alan Spradling where he first focused on defining the metabolic transitions that drive oocyte development and support reproductive competence. Most recently, he has shown that, in response to decreased insulin/Akt signaling, remodeling of the mitochondrial electron transport chain (ETC) dramatically reduces mitochondrial activity and underlies the pronounced cellular quiescence observed in oocytes from many species. And he has demonstrated that ETC remodeling is a conserved aspect of oogenesis in vertebrate (Xenopus) and mouse development. His work has been published in Current Biology and Cell, and was funded by a Jane Coffin Childs postdoctoral fellowship. Dr. Sieber is interviewing for the DCMB faculty position in Biology department, yet his talk will be of interest to most faculty graduate students and postdoctoral researches in CMB, DSCB, and UPGG.

Type: LECTURE/TALK
Contact: Caroline Usher