Ontogeny and regulation of the airway stem cell pool in the lung
Wellington V. Cardoso, MD, PhD, is the Director of the Columbia Center for Human Development, Professor of Medicine at the Division of Pulmonary and Critical Care Medicine, Department of Medicine, and Professor of Genetics and Development at Columbia University Medical Center. Dr. Cardoso's research focuses on the mechanisms that regulate lung development and regeneration-repair of the lung. For nearly two decades his laboratory has been making relevant contributions to the field, providing insights into how developmental signals, such as retinoic acid, Fgf, Tgf beta and Notch control lung progenitor cell development, airway branching and epithelial differentiation. These studies have also contributed to the understanding of mechanisms controlling lung regeneration-repair and of the impact of prenatal fetal exposures in the adult lung function and susceptibility to disease.
Research: Lung development and repair-regeneration, developmental signaling by retinoic acid, Notch, Hippo pathways; control of airway epithelial cell fate in stem/progenitor cells, developmental programming in ES/iPS cells; ciliogenesis; developmental pathways in postnatal lung disease.