Pathology Grand Rounds - DNA Mismatch Repair: Beyond a Screening Tool for Hereditary Cancer

At the conclusion of this activity, learners should be able to:

* Discuss the changing mortality trends for endometrial cancer over the last 10 years

* Discuss the relationship between endometrial cancer, obesity, and MLH1 gene methylation

* Understand the impact of tumor MLH1 gene methylation on survival in endometrial cancer patients

* Understand the dynamic range of tumor infiltrating lymphocytes in mismatch repair-intact and -deficient endometrial cancers

* Discuss impacts of variable expression of MMR proteins in endometrial cancers