Voltage-gated sodium channels as targets of pyrethroid insecticides
Voltage-gated sodium channels are critical for electrical signaling in the nervous system. They are a major target of many naturally-occurring neurotoxins from plants and animals as well as several classes of insecticides including pyrethroids. Pyrethroid insecticides have been used widely for control arthropod pests and disease vectors due to their low mamammlian toxicity. Besides their insecticidal activities, volatile pyrethroids are also potent repellents against mosquitoes. In her seminar, Dr. Dong will talk about the mechanism of insecticidal action and resistance of pyrethroid insecticides. She will also present recent work that shed light on the mechansims of pyrethroid repellency in Aedes aegypti, a major human disease vector.
Live Zoom presentation. Register to receive Zoom link at: https://duke.zoom.us/meeting/register/tJArdOmurjIuG9fQglBsNt2pzhguWVSueX9X