FIP Seminar: Multi-parametric Photoacoustic Microscopy - Auscultation of Hemodynamics and Energy Metabolism at the Microscopic Level
Song Hu is currently an assistant professor of Biomedical Engineering at the University of Virginia, member of the Robert M. Berne Cardiovascular Research Center and the Cancer Center, and director of Biomedical Optics & Ultrasound Lab. He has published more than 50 peer-reviewed papers and 5 book chapters. His recent papers, including the 4th and 6th most cited articles in the Journal of Biomedical Optics since 2009 and the 5th most cited article in Optics Letters since 2007, have accumulated over 4,000 citations. His lab pioneers the development and application of photoacoustic microscopy (PAM) for basic and translational research in neuroscience, cardiovascular biology, cancer, and regenerative medicine. In particular, his lab has developed multi-parametric PAM, which enables-for the first time-simultaneous label-free imaging of hemoglobin concentration, blood oxygenation, and blood flow at the microscopic level in vivo. Moreover, his lab has developed multi-spectral PAM for concurrent imaging of multiple key endogenous biomolecules (including DNA/RNA, hemoglobin and lipid) and all-optical PAM with near-isotropic spatial resolution. Recently, his lab has developed the first-of-a-kind head-restrained PAM for high-resolution imaging of cerebral hemodynamics and metabolism in awake behaving animals, addressing a long-standing technical challenge in neuroscience research. Dr. Hu serves on the editorial boards of Scientific Reports, Neurophotonics, and Photoacoustics.