The Ruth K. Broad Foundation Seminar Series on Neurobiology and Disease
The goal of Dr. Picciotto's research team is to understand the role of single molecules in complex behaviors related to addiction, depression, feeding and learning. She and her colleagues use molecular genetic and pharmacological approaches to link the biochemical, cellular, and anatomical levels of investigation to behavior. Of primary interest is the role of acetylcholine and nicotinic acetylcholine receptors in brain function and development, as well as sex differences in molecular and circuit-level signaling relevant for behavior.
Dr. Picciotto's laboratory also studies signaling molecules downstream of nicotinic receptors, such as calcineurin, CaM kinases and adducins, which may mediate long-term changes in behavior downstream of these receptors.