Leveraging linkage disequilibrium in analyses of human genomes

Correlation among genotypes in human population-genetic datasets complicates the localization of both adaptive mutations and disease-causing mutations. Recently, my research group's focus has been on developing and apply methods for localizing adaptive and disease-causing mutations. I'll describe our latest efforts in these areas, focusing on bridging the gap between polygenic and omnigenic complex traits, and charting a new course for multiethnic genome-wide association studies.