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Pathology Grand Rounds - ctDNA Genomics and Beyond Genomics: An Approach of Inferring Epigenetically Diverse Phenotypic Subtypes of Prostate Cancer

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Friday, May 26, 2023
12:00 pm - 1:00 pm
Navonil De Sarkar, PhD, Medical College of Wisconsin
Current Topics in Pathology 2023

At the conclusion of this activity, learners should be able to:

* Nucleosome profiles from ctDNA can accurately depict prostate cancer epigenetic subtypes/phenotypic subtypes

* With our approach we can derive AR activity signature from ctDNA

* It is feasible to use AS activity signature as clinical determinant for standard of care antiandrogen therapy responses

* Potential tool for precision medicine for monitoring therapy-induced disease evolution