BEGIN:VCALENDAR PRODID:BedeWork V3.5 VERSION:2.0 METHOD:PUBLISH BEGIN:VTIMEZONE TZID:America/New_York X-LIC-LOCATION:America/New_York BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:20070311T020000 RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=2SU END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 TZNAME:EST DTSTART:20071104T020000 RRULE:FREQ=YEARLY;BYMONTH=11;BYDAY=1SU END:STANDARD BEGIN:STANDARD TZOFFSETFROM:-045602 TZOFFSETTO:-0500 TZNAME:EST DTSTART:18831118T120358 RDATE:18831118T120358 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:19180331T020000 RDATE:19180331T020000 RDATE:19190330T020000 RDATE:19200328T020000 RDATE:19210424T020000 RDATE:19220430T020000 RDATE:19230429T020000 RDATE:19240427T020000 RDATE:19250426T020000 RDATE:19260425T020000 RDATE:19270424T020000 RDATE:19280429T020000 RDATE:19290428T020000 RDATE:19300427T020000 RDATE:19310426T020000 RDATE:19320424T020000 RDATE:19330430T020000 RDATE:19340429T020000 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CATEGORIES:Other CATEGORIES:Utilities CATEGORIES:Health/Wellness CATEGORIES:Workshop/Short Course CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20221003T115034Z DESCRIPTION:In this foundational workshop\, students will work on clarifyi ng and articulating their career goals\, including how to move forward ev en if those goals are not crystal clear. This will be an interactive wor kshop\, including various exercises through which students will start to create longer-term visions from which they will build out a plan for thei r time at Pratt. Students will leave with an understanding of self-dire cted learning\, where they are on that scale\, and a plan for how to move forward on their internship search\, job search\, or taking their next m ost important step. DURATION:PT1H30M DTSTAMP:20221003T171823Z DTSTART;TZID=America/New_York:20221014T133000 LAST-MODIFIED:20221003T171823Z LOCATION;X-BEDEWORK-UID=18832edc-1b23ba5b-011b-27d7eabe-0000001d:Biologica l Sciences 111 STATUS:CONFIRMED SUMMARY:What Am I Doing Here? How to Make the Most of your Master's Degre e UID:CAL-8a0183a7-83184018-0183-9daefc5f-00006fb2demobedework@mysite.edu URL:https://duke.joinhandshake.com/events/1140389/share_preview X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Workshop_Short_Course:/user/ public-user/Other/Workshop_Short_Course X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Health_Wellness:/user/public -user/Topics/Health_Wellness X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Engineering:/user/public-use r/Topics/Engineering X-BEDEWORK-CS;X-BEDEWORK-PARAM-DESCRIPTION="/principals/users/agrp_PrattSc hool,":Pratt School of Engineering X-BEDEWORK-SPEAKER:Sarah Carlson X-BEDEWORK-DUKE-SERIES:Pratt Masters Professional Development Workshops X-BEDEWORK-SUBMITTEDBY:pjm15 for Engineering Master'\;s Career Services and Professional Development (agrp_Pratt_MastersCSPD) END:VEVENT BEGIN:VEVENT CATEGORIES:Engineering CATEGORIES:Other CATEGORIES:Utilities CATEGORIES:Health/Wellness CATEGORIES:Workshop/Short Course CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20221003T121145Z DESCRIPTION:You can get the best grades and be the very best in your field \, but it may not matter if you can't effectively communicate this to emp loyers\, clients\, or stakeholders. In this workshop\, participants will learn how to create authentic\, persuasive narratives that will get empl oyers' attention\, no matter what type of employer it is. Students will learn to identify themes that clearly set them apart and how to make thei r value clear and apparent in both their resumes and cover letters. Stud ents will leave with resume formats and formulas designed specifically fo r their success! DURATION:PT1H30M DTSTAMP:20221003T121145Z DTSTART;TZID=America/New_York:20221028T133000 LAST-MODIFIED:20221003T121145Z LOCATION;X-BEDEWORK-UID=18832edc-1b23ba5b-011b-27d7eabe-0000001d:Biologica l Sciences 111 STATUS:CONFIRMED SUMMARY:The Art of Self-Articulation: How to Build Powerful Resumes and Co ver Letters UID:CAL-8a0183a7-83184018-0183-9dc260eb-0000705edemobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Workshop_Short_Course:/user/ public-user/Other/Workshop_Short_Course X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Engineering:/user/public-use r/Topics/Engineering X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Health_Wellness:/user/public -user/Topics/Health_Wellness X-BEDEWORK-SPEAKER:Sarah Carlson X-BEDEWORK-DUKE-SERIES:Pratt Masters Professional Development Workshops X-BEDEWORK-DUKE-WEBCAST:https://duke.zoom.us/j/93684237164 X-BEDEWORK-SUBMITTEDBY:pjm15 for Engineering Master's Career Services and Professional Development (agrp_Pratt_MastersCSPD) END:VEVENT BEGIN:VEVENT CATEGORIES:Engineering CATEGORIES:Other CATEGORIES:Utilities CATEGORIES:Workshop/Short Course CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a0183a7-83184018-0183-992404fa-00004d05:Ryan-Murra y\, Pegeen CREATED:20221003T143446Z DESCRIPTION:Effective communication requires us to be clear and complete i n what we are trying to express. In this workshop\, you will gain the sk ills to exchange information with clarity\, empathy\, and understanding\, so you can effectively connect with faculty\, staff\, potential employer s\, clients\, and more! Students will leave with the top techniques and increased confidence to express themselves effectively\, which is essent ial to professional success. DURATION:PT1H30M DTSTAMP:20221003T181935Z DTSTART;TZID=America/New_York:20221104T133000 LAST-MODIFIED:20221003T181935Z LOCATION;X-BEDEWORK-UID=18832edc-1b23ba5b-011b-27d7eabe-0000001d:Biologica l Sciences 111 STATUS:CONFIRMED SUMMARY:Effective Communication for Workplace Success UID:CAL-8a0183a7-83184018-0183-9e45541a-000074b0demobedework@mysite.edu URL:https://duke.joinhandshake.com/events/1124853/share_preview X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Workshop_Short_Course:/user/ public-user/Other/Workshop_Short_Course X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Engineering:/user/public-use r/Topics/Engineering X-BEDEWORK-SPEAKER:Sue Brien X-BEDEWORK-DUKE-SERIES:Pratt Masters Professional Development Workshops X-BEDEWORK-SUBMITTEDBY:pjm15 for Engineering Master'\;s Career Services and Professional Development (agrp_Pratt_MastersCSPD) END:VEVENT BEGIN:VEVENT CATEGORIES:Engineering CATEGORIES:Other CATEGORIES:Utilities CATEGORIES:Workshop/Short Course CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a0183a7-83184018-0183-992404fa-00004d05:Ryan-Murra y\, Pegeen CREATED:20221003T152636Z DESCRIPTION:Job and internship searches often take time\, but in this work shop you will learn the most efficient and effective methods for getting where you want to go. Students will leave this workshop with the best to ols to find opportunities\, connect with employers\, highlight their own value\, and significantly increase their chances of getting that next rol e. Why make it harder than it has to be? Join us for this interactive w orkshop and get the things you need to make your search a success. DURATION:PT1H30M DTSTAMP:20221003T194814Z DTSTART;TZID=America/New_York:20221111T133000 LAST-MODIFIED:20221003T194814Z LOCATION;X-BEDEWORK-UID=18832edc-1b23ba5b-011b-27d7eabe-0000001d:Biologica l Sciences 111 STATUS:CONFIRMED SUMMARY:The Successful Search: Strategies for Getting a US-Based Job or In ternship UID:CAL-8a0183a7-83184018-0183-9e74c8b4-00007a2edemobedework@mysite.edu URL:https://duke.joinhandshake.com/events/1124873/share_preview X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Workshop_Short_Course:/user/ public-user/Other/Workshop_Short_Course X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Engineering:/user/public-use r/Topics/Engineering X-BEDEWORK-SPEAKER:Angelica Ramirez Blanks X-BEDEWORK-DUKE-SERIES:Pratt Masters Professional Development Workshops X-BEDEWORK-SUBMITTEDBY:pjm15 for Engineering Master&\;#39\;s Career Ser vices and Professional Development (agrp_Pratt_MastersCSPD) END:VEVENT BEGIN:VEVENT CATEGORIES:Engineering CATEGORIES:Other CATEGORIES:Utilities CATEGORIES:Health/Wellness CATEGORIES:Workshop/Short Course CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a0183a7-83184018-0183-992404fa-00004d05:Ryan-Murra y\, Pegeen CREATED:20221003T155212Z DESCRIPTION:This high energy\, interactive workshop incorporates games to develop camaraderie\, creativity\, humor\, and spontaneous thinking in a way that is refreshingly honest and thought-provoking. The format will e xplore how students can use improv techniques to improve their approach t o presentations\, interviewing\, leadership and collaboration. Join Paul for this workshop to gain confidence in your capacity to speak and lead effectively. DURATION:PT1H30M DTSTAMP:20221003T195022Z DTSTART;TZID=America/New_York:20221118T133000 LAST-MODIFIED:20221003T195022Z LOCATION;X-BEDEWORK-UID=18832edc-1b23ba5b-011b-27d7eabe-0000001d:Biologica l Sciences 111 STATUS:CONFIRMED SUMMARY:Leading with Laughter UID:CAL-8a0183a7-83184018-0183-9e8c36bf-0000019ddemobedework@mysite.edu URL:https://duke.joinhandshake.com/events/1124888/share_preview X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Workshop_Short_Course:/user/ public-user/Other/Workshop_Short_Course X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Engineering:/user/public-use r/Topics/Engineering X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Health_Wellness:/user/public -user/Topics/Health_Wellness X-BEDEWORK-SPEAKER:Paul Marks X-BEDEWORK-DUKE-SERIES:Pratt Masters Professional Development Workshops X-BEDEWORK-SUBMITTEDBY:pjm15 for Engineering Master'\;s Career Services and Professional Development (agrp_Pratt_MastersCSPD) END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20230118T194732Z DESCRIPTION:Postdoctoral Researcher at Stanford University.\nAbstract: The lives and forms of parasitic organisms showcase striking biophysical phe nomena. My work explores cellular dynamics\, tissue mechanics\, and morph ogenesis through key phenomena in the lives of eukaryotic parasites: moti lity\, penetration of host tissue\, and organismal shape change. This tal k will focus on gliding motility\, the unique form of cell locomotion use d by unicellular apicomplexan parasites like Toxoplasma gondii and the Pl asmodium species that cause malaria. Apicomplexan parasites use gliding t o move through a host body during infection\, and gliding is powered by a thin layer of flowing actin filaments at the parasite surface. How does the collective motion of surface actin filaments emerge\, and how does it drive the varied parasite gliding movements that we observe experimental ly? I will present findings based on single-molecule imaging in Toxoplasm a gondii parasites and use continuum flocking theory to predict emergent filament flows in the unusual confines provided by parasite geometry. Thi s actin filament flocking model enables the exploration of distinct self- organized states tuned by filament lifetime\, which can account for the d iversity of observed Toxoplasma gliding motions. This theory-experiment i nterplay illustrates how different forms of gliding motility can arise as an intrinsic consequence of self-organized actin filament flows at a cel l surface. DURATION:PT1H DTSTAMP:20230125T144717Z DTSTART;TZID=America/New_York:20230202T153000 LAST-MODIFIED:20230125T144717Z LOCATION;X-BEDEWORK-UID=18832edc-1b23ba5b-011b-27d7eabe-0000001d:Biologica l Sciences 111 STATUS:CONFIRMED SUMMARY:Biology Seminar | Christina Hueschen\, PhD | Stanford University | Emergent Actin Flows Explain Distinct Modes of Gliding Motility UID:CAL-8a0290cd-85a68f68-0185-c66c1ecb-00005939demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=bbooher@duke.edu:Blythe Boquist X-BEDEWORK-SUBMITTEDBY:bbooher for Biology (agrp_ArtsandSciences_Biology) END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20230112T165455Z DESCRIPTION:Assistant Professor\, Department of Biology.\nAbstract: Female -female competition is widespread\, but relative to male-male competition \, we know less about its causes and consequences. The Lipshutz Lab studi es the evolution of female competition across diverse avian species\, ran ging from territorially aggressive songbirds to socially polyandrous shor ebirds. Our work bridges "muddy boots" experimental fieldwork in wild\, f ree-living animals with a variety of molecular and computational approach es in population genomics\, endocrinology\, and neuro-transcriptomics. Ou r focus on a context that is relevant to both sexes - competition over es sential breeding resources - provides a useful framework for co-considera tion of proximate and ultimate drivers of reproductive competition in fem ale and male animals. DURATION:PT1H DTSTAMP:20230201T202813Z DTSTART;TZID=America/New_York:20230209T153000 LAST-MODIFIED:20230201T202813Z LOCATION;X-BEDEWORK-UID=18832edc-1b23ba5b-011b-27d7eabe-0000001d:Biologica l Sciences 111 STATUS:CONFIRMED SUMMARY:Biology Seminar | Sara Lipshutz\, PhD | Loyola University Chicago | Fighting for fitness: integrating behavioral\, hormonal\, and genomic p erspectives on the evolution of female competition UID:CAL-8a0290cd-85a68f68-0185-a6e7eda7-000010e5demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=bbooher@duke.edu:Blythe Boquist X-BEDEWORK-SUBMITTEDBY:bbooher for Biology (agrp_ArtsandSciences_Biology) END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20230112T165952Z DESCRIPTION:Postdoctoral Scholar\, Department of Integrative Biology\nAbst ract: Variations in life forms\, ranging from genetic\, phylogenetic\, fu nctional\, taxonomic\, to ecosystem levels\, are striking across time and space. I am particularly interested in synthesizing phylogenetic and eco logical data to answer research questions relating to the diversification \, distribution\, and diversity of plants across multiple spatial and tem poral scales. Using Rubiaceae as a reference study system\, I will invest igate the rates and drivers of net diversification in Rubiaceae\, in comp arison with sister clades\, and how diversification rates vary across the pantropical distribution of Rubiaceae. Findings from these studies will contribute to the global Rubiaceae phylogeny and to map the spatial phylo genetic diversity of spermatophytes in tropical rainforests. I will also leverage data collected from extensive field sampling and phylogenetic an alyses to broadly investigate the role of trait-habitat associations\, bi otic interactions\, and phylogenetic relationships drive vegetative commu nity assemblages across ecosystem types. DURATION:PT1H DTSTAMP:20230209T171244Z DTSTART;TZID=America/New_York:20230216T153000 LAST-MODIFIED:20230209T171244Z LOCATION;X-BEDEWORK-UID=18832edc-1b23ba5b-011b-27d7eabe-0000001d:Biologica l Sciences 111 STATUS:CONFIRMED SUMMARY:Biology Seminar | Israel Borokini\, PhD | University of California Berkeley | Eco-evolutionary drivers of spatiotemporal distributions of b iodiversity | UID:CAL-8a0290cd-85a68f68-0185-a6ec7691-000010e8demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=bbooher@duke.edu:Blythe Boquist X-BEDEWORK-SUBMITTEDBY:bbooher for Biology (agrp_ArtsandSciences_Biology) END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20230118T194936Z DESCRIPTION:NSF-Postdoctoral Research Fellow.\nAbstract: A central aim of evolutionary developmental biology is to elucidate the connection between genomic features and the wide variety of forms and shapes in the natural world. By studying the evolution of butterfly wing color patterns - a tw o-dimensional\, tractable system for developmental and functional genetic s - I am making connections between genomes\, key developmental signals\, and the evolution of the stunning morphological diversity found in these insects. In particular\, I tested Wnt gene functions in patterning butte rfly wing color elements and characterized the regulatory architecture mo dulating the role of the WntA signaling gene. My findings show that WntA instructs the shape of color arrays in both butterflies and swallowtails\ , repurposing previously existing patterns\, evolving new ones\, and comb ining with additional Wnt signals to create complex outputs. Sequence ana lysis of open chromatin DNA regions reveals extensive conservation of the WntA regulatory landscape across nymphalids\, with a notable exception i n the morphologically-derived monarch butterflies. Individual CRE deletio ns consistently led to overlapping color pattern changes\, most of which induced both WntA loss- and gain-of-function effects on the wing patterns \, suggesting that morphological tuning involved the subtle tinkering of an array of deeply ancestral\, multifunctional sequences. These results e stablish butterfly color patterns as an integrative system to investigate mechanisms of Wnt signal transduction\, its regulation\, and shape diver sification. DURATION:PT1H DTSTAMP:20230220T184638Z DTSTART;TZID=America/New_York:20230223T153000 LAST-MODIFIED:20230220T184638Z LOCATION;X-BEDEWORK-UID=18832edc-1b23ba5b-011b-27d7eabe-0000001d:Biologica l Sciences 111 STATUS:CONFIRMED SUMMARY:Biology Seminar | Anyi Mazo-Vargas\, PhD | George Washington Unive rsity | The complex art of butterfly wing color patterning—From DNA to si gnals to diversity UID:CAL-8a0290cd-85a68f68-0185-c66e0285-00005a59demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=bbooher@duke.edu:Blythe Boquist X-BEDEWORK-SUBMITTEDBY:bbooher for Biology (agrp_ArtsandSciences_Biology) END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20230131T144133Z DESCRIPTION:The Department of Chemistry is excited to host Professor Squir e Booker (Pennsylvania State University) for the annual Douglas G. Hill M emorial Lecture.\n\n"A Radical Solution for C(sp3)-C(sp3) Bond Formation during the Biosynthesis of Macrocyclic Membrane Lipids"\n\nArchaea synthe size isoprenoid-based ether-linked membrane lipids\, which enable them to withstand extreme environmental conditions\, such as high temperatures\, high salinity\, and low or high pH values. In some archaea\, such as Met hanocaldococcus jannaschii\, these lipids are further modified by forming carbon-carbon bonds between the termini of two lipid tails within one gl ycerophospholipid to generate the macrocyclic archaeol or forming two car bon-carbon bonds between the termini of two lipid tails from two glycerop hospholipids to generate the macrocycle glycerol dibiphytanyl glycerol te traether (GDGT). GDGT contains two 40-carbon lipid chains (biphytanyl cha ins) that span both leaflets of the membrane\, providing enhanced\nstabil ity to extreme conditions. How these specialized lipids are formed has pu zzled scientists for decades. The reaction necessitates coupling two comp letely inert sp3-hybridized carbon centers\, which has not been observed in nature. Here we use X-ray crystallography\, high-resolution mass spect rometry\, chemical synthesis\, and biochemical analyses to show that the gene product of mj0619 from M. jannaschii\, which encodes a radical S-ade nosylmethionine enzyme\, is responsible for biphytanyl chain formation du ring synthesis of both the macrocyclic archaeol and GDGT membrane lipids. \n\nTo learn more about Prof. Squire Booker's research\, please visit:\n https://sites.psu.edu/sjbookerlab/ DURATION:PT1H30M DTSTAMP:20230222T165205Z DTSTART;TZID=America/New_York:20230310T160000 LAST-MODIFIED:20230222T165205Z LOCATION;X-BEDEWORK-UID=18832edc-1b23ba5b-011b-27d7eabe-0000001d:Biologica l Sciences 111 STATUS:CONFIRMED SUMMARY:Douglas G. Hill Memorial Lecture Presented by Prof. Squire Booker: "A Radical Solution for C(sp3)–C(sp3) Bond Formation during the Biosynth esis of Macrocyclic Membrane Lipids" UID:CAL-8a0290b4-860465b2-0186-0846a7b7-00003fa7demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Dep artment of Chemistry X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-SPEAKER:Prof. Squire Booker\, Pennsylvania State University X-BEDEWORK-IMAGE-X1:13 X-BEDEWORK-IMAGE-Y1:111 X-BEDEWORK-IMAGE-X2:579 X-BEDEWORK-IMAGE-Y2:488.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:566 X-BEDEWORK-IMAGE-CROP-HEIGHT:377.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Professor Squire Booker X-BEDEWORK-IMAGE:/public/Images/SquireBooker3_20220617031336PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/SquireBooker3_20220617031336PM-thumb .png END:VEVENT END:VCALENDAR