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CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a087089-35e3fb8e-0136-59bd57dc-0000557a:Schreiber\ , Tanya CREATED:20220908T164729Z DESCRIPTION:Tierney Daw is in the Hull Lab. DURATION:PT1H DTSTAMP:20220908T164729Z DTSTART;TZID=America/New_York:20220914T120000 LAST-MODIFIED:20220908T164729Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Candelabrum cells: more than just gaudy decor UID:CAL-8a0183a7-83184018-0183-1dffd7f3-00005251demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Tierney Daw X-BEDEWORK-DUKE-SERIES:Neurobiology Student Seminar X-BEDEWORK-SUBMITTEDBY:jas36 for Neurobiology (agrp_SchoolofMedicine_Neuro biology) END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a087089-35e3fb8e-0136-59bd57dc-0000557a:Schreiber\ , Tanya CREATED:20220908T163907Z DESCRIPTION:Cells throughout the human body detect mechanical forces. Whil e it is known that the rapid (millisecond) detection of mechanical forces is mediated by force-gated ion channels\, technological limitations have precluded a detailed quantitative understanding of cells as sensors of m echanical energy. Here\, I describe the development and validation of a s ystem combining atomic force microscopy with patch-clamp electrophysiolog y. Using this system\, I develop a quantitative framework for describing cells as sensors of mechanical energy and determine the physical limits o f detection and resolution of mechanical energy for cells expressing the force-gated ion channels Piezo1\, Piezo2\, TREK1\, and TRAAK. I find that \, depending on the identity of the channel\, cells can function either a s proportional or nonlinear transducers of mechanical energy\, detect mec hanical energies as little as ~70 fJ\, and with a resolution of up to ~1 fJ. I also make the surprising discovery that cells can transduce forces either nearly instantaneously (< 1ms)\, or with substantial time delay (~ 10 ms) dependent on the identity of the channel. Using a chimeric experim ental approach and simulations we show how such delays can emerge from ch annel-intrinsic properties and the slow diffusion of tension in cellular membranes. Further\, I explore the role that cellular properties such as cell size\, channel density\, and actin cytoarchitecture play in tuning t he biophysical limits of rapid cellular mechanotransduction. Overall\, ou r experiments reveal the capabilities and limits of cellular mechanosensi ng and provide insights into molecular mechanisms that different cell typ es may employ to specialize for their distinct physiological roles. DURATION:PT1H DTSTAMP:20220909T030832Z DTSTART;TZID=America/New_York:20220919T120000 LAST-MODIFIED:20220909T030832Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:The Energetics of Rapid Cellular Mechanotransduction UID:CAL-8a0183a7-83184018-0183-1df8312c-000050d4demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-SPEAKER:Michael Young X-BEDEWORK-DUKE-SERIES:Neurobiology Dissertation Seminar X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:-0.3333333333333144 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:353 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Michael Young X-BEDEWORK-SUBMITTEDBY:jas36 for Neurobiology (agrp_SchoolofMedicine_Neuro biology) X-BEDEWORK-IMAGE:/public/Images/MichaelYoungResized_20220909030833AM.png X-BEDEWORK-THUMB-IMAGE:/public/Images/MichaelYoungResized_20220909030833AM -thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a087089-35e3fb8e-0136-59bd57dc-0000557a:Schreiber\ , Tanya CREATED:20220909T183753Z DESCRIPTION:Anxiety is a behavioral state induced by low-threat\, uncertai n situations in which perceived danger is diffuse. The anxiety state is t hen accompanied by increased vigilance and risk assessment to one's surro undings. Recent studies have shown that the brain regions responsible for encoding anxiety are widely located in the frontal cortex and extended l imbic system\; however\, the network architecture responsible for hypervi gilance has yet to be elucidated. Here\, I propose to employ a data-drive n method of using in vivo recordings of electrical activity across multip le brain regions concurrently as mice freely explore classic ethological anxiety-related behavioral assays and are administered pharmacological ag ents that modulate the anxiety state. Using novel machine-learning techni ques\, I have generated neural models that reflect the network-level acti vity engaged during the performance of these tasks. I have then validated the structure of this anxiety network in its ability to generalize to ot her anxiety-related tasks and models of disease. I anticipate that this s trategy will discover an independent network that is correlated with anxi ety-related behaviors. Thus\, successful completion of the proposed work will lead to a network-level understanding of anxiety. Furthermore\, the framework discovered through this study has the potential to facilitate t he development of new revolutionary approaches for anxiety disorders. DURATION:PT1H DTSTAMP:20220909T184528Z DTSTART;TZID=America/New_York:20220920T100000 LAST-MODIFIED:20220909T184528Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:A Data-Driven Approach to Uncovering the Neural Dynamics of Anxiet y UID:CAL-8a0183a7-83184018-0183-238b456e-00001dd9demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-SPEAKER:Dalton Hughes X-BEDEWORK-SUBMITTEDBY:ts168 for Neurobiology (agrp_SchoolofMedicine_Neuro biology) X-BEDEWORK-DUKE-SERIES:Neurobiology Dissertation Seminar X-BEDEWORK-IMAGE-X1:13 X-BEDEWORK-IMAGE-Y1:5 X-BEDEWORK-IMAGE-X2:543 X-BEDEWORK-IMAGE-Y2:358.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Dalton Hughes headshot X-BEDEWORK-IMAGE:/public/Images/DHughes_Headshot_resized_20220909064528PM. jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/DHughes_Headshot_resized_20220909064 528PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Panel/Seminar/Colloquium CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a087089-35e3fb8e-0136-59bd57dc-0000557a:Schreiber\ , Tanya CREATED:20220916T135455Z DESCRIPTION:Sara Gannon is in Glickfeld Lab. DURATION:PT1H DTSTAMP:20220916T135455Z DTSTART;TZID=America/New_York:20220921T120000 LAST-MODIFIED:20220916T135455Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:More morphology! Dendritic architecture and input shape tuning UID:CAL-8a0183a7-83184018-0183-4694bb5f-00006ee1demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Panel_Seminar_Colloquium:/us er/public-user/Lectures_Conferences/Panel_Seminar_Colloquium X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Sara Gannon X-BEDEWORK-DUKE-SERIES:Neurobiology Student Seminar X-BEDEWORK-SUBMITTEDBY:ts168 for Neurobiology (agrp_SchoolofMedicine_Neuro biology) END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Health/Wellness CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=2c918083-666bc169-0166-83a7e4a8-00002f83:Garrett\, Angela CREATED:20220801T194853Z DESCRIPTION:5:30pm - 6:00pm - Reception\n6:00pm - 7:00pm - Lecture\n\nRand all J. Bateman\, MD is the Charles F. and Joanne Knight Distinguished Pro fessor of Neurology at Washington University School of Medicine\, directo r of the Dominantly Inherited Alzheimer Network (DIAN) and director of th e DIAN Trials Unit(DIAN-TU).\n\nBateman's laboratory investigates the cau ses and methods of diagnosis and treatment of Alzheimer's disease (AD) ut ilizing a wide variety of assays and techniques. His lab recently reporte d on a highly accurate blood test for Alzheimer's disease amyloid plaques which can detect AO pathology decades before symptoms of the disease dev elop. The Bateman lab has focused research projects on tau isoform specie s in brain\, CSF and blood\, and also neurofilament biomarkers.\n\nBatema n's research in DIAN has provided evidence for a cascade of events beginn ing decades before symptom onset that leads to Alzheimer's disease dement ia\, supporting development of Alzheimer's disease prevention trials. Thi s focus on deep scientific involvement in Alzheimer's disease has led to seminal scientific discoveries\, breakthroughs in cerebral spinal fluid ( CSF) and blood diagnostic testing and groundbreaking translational studie s and therapeutic trials. In 2010\, Bateman organized the Autosomal Domin ant Alzheimer's Disease Forum\, a patient and family advocacy group\, and then launched world­ wide meetings for family members which have grown i nto annual meetings with family members attending from most continents. T he DIAN Expanded Registry is the portal for families with dominantly inhe rited Alzheimer's disease to become connected to the DIAN studies and oth er families around the world.\n\nHe has collaborated with the FDA\, Natio nal Institutes of Health (NIH)\, biotech and pharmaceutical companies. Ba teman's many honors include the Scientific American 50 Award recognizing the top SO scientific achievements and the 2019 Potamkin Prize given each year to the leading Alzheimer's research and is a member of the National Academy of Medicine. DURATION:PT1H30M DTSTAMP:20220801T200551Z DTSTART;TZID=America/New_York:20220921T173000 LAST-MODIFIED:20220801T200551Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Karen L. Wrenn Lectureship: From Diagnostic Tests to Prevention Tr ials: Advances in Alzheimer's Disease UID:CAL-8a018f14-821da122-0182-5af44269-00000cd0demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Health_Wellness:/user/public -user/Topics/Health_Wellness X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-CS;X-BEDEWORK-PARAM-DESCRIPTION="/principals/users/agrp_Centerf orAgingandHumanDevelopment,/principals/users/agrp_SOM_ClinDep_Neurology," :Center for Aging and Human Development\,Department of Neurology X-BEDEWORK-SPEAKER:Randall J. Bateman\, MD X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:0 X-BEDEWORK-IMAGE-X2:529.5 X-BEDEWORK-IMAGE-Y2:353 X-BEDEWORK-IMAGE-CROP-WIDTH:529.5 X-BEDEWORK-IMAGE-CROP-HEIGHT:353 X-BEDEWORK-IMAGE-ALT-TEXT:Randall J. Bateman\, MD X-BEDEWORK-SUBMITTEDBY:ag168 for Department of Psychiatry and Behavioral S ciences (agrp_ClinDep_Psychiatry) X-BEDEWORK-IMAGE:/public/Images/Bateman\, 92122_20220801074853PM.png X-BEDEWORK-THUMB-IMAGE:/public/Images/Bateman\, 92122_20220801074853PM-thu mb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Engineering CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None X-BEDEWORK-COST:free CREATED:20220629T153518Z DESCRIPTION:Non-Invasive Closed-Loop Neural Prostheses for Epilepsy DURATION:PT1H DTSTAMP:20220906T123851Z DTSTART;TZID=America/New_York:20220922T120000 LAST-MODIFIED:20220906T123851Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Non-Invasive Closed-Loop Neural Prostheses for Epilepsy UID:CAL-8a039360-81409ef1-0181-b01a3c73-00000ce3demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Engineering:/user/public-use r/Topics/Engineering X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-CS;X-BEDEWORK-PARAM-DESCRIPTION="/principals/users/agrp_PrattSc hool_BME,/principals/users/agrp_SchoolofMedicine_Neurobiology,/principals /users/agrp_PrattSchool,":Biomedical Engineering (BME)\,Neurobiology\,Pra tt School of Engineering X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=warren.grill@duke.edu:Wa rren Grill\, PhD X-BEDEWORK-SPEAKER:Pedro Irazoqui\, Johns Hopkins University X-BEDEWORK-DUKE-SERIES:Duke Seminars in Neural Engineering X-BEDEWORK-LOCATION:Wilkinson Building 132 X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:83 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:436.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Image of Pedro Irazoqui\, man with beard X-BEDEWORK-SUBMITTEDBY:cmb152 for Duke Institute for Brain Sciences (DIBS) (agrp_InstituteforBrainSciences) X-BEDEWORK-IMAGE:/public/Images/Pedro Irazoqui_20220629033500PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/Pedro Irazoqui_20220629033500PM-thum b.png END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=2c918085-6bd28f39-016b-f64ac821-00003e49:Kornbluth\ , Jennifer CREATED:20220804T194943Z DESCRIPTION:Dr. Regehr is a Professor of Neurobiology at Harvard Medical S chool and interested in synapses\, short term plasticity\, and the cerebe llum.\n\nThe cerebellar cortex transforms mossy fiber inputs into Purkinj e cell outputs. A basic framework was developed 50 years ago for how the relatively small number of neuron types performs and refines these trans formations. Recent advances will be described that have provided new ins ights into the circuit elements that make up the cerebellar cortex. RNAs eq studies have identified different types and subtypes of neurons. Elec trophysiological characterization of these neuron types and subtypes have revealed distinctive firing properties and synaptic inputs and outputs. Serial electron microscopy reconstructions of the circuitry have clarifie d the connections between different circuit elements. Granule cells\, mo lecular layer interneurons\, candelabrum cells\, unipolar brush cells\, a nd Purkinje cells will be discussed. DURATION:PT1H DTSTAMP:20220923T185124Z DTSTART;TZID=America/New_York:20221004T120000 LAST-MODIFIED:20220923T185124Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Invited Seminar: Circuit Elements of the Cerebellar Cortex UID:CAL-8a018f14-821da122-0182-6a681cdf-00000d3cdemobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Wade Reghehr\, hosted by Jim McNamara X-BEDEWORK-DUKE-SERIES:Neurobiology Invited Seminar Series X-BEDEWORK-IMAGE-X1:3 X-BEDEWORK-IMAGE-Y1:3 X-BEDEWORK-IMAGE-X2:7.5 X-BEDEWORK-IMAGE-Y2:6 X-BEDEWORK-IMAGE-CROP-WIDTH:4.5 X-BEDEWORK-IMAGE-CROP-HEIGHT:3 X-BEDEWORK-IMAGE-ALT-TEXT:Wade Reghehr X-BEDEWORK-SUBMITTEDBY:jas36 for Neurobiology (agrp_SchoolofMedicine_Neuro biology) END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a087089-35e3fb8e-0136-59bd57dc-0000557a:Schreiber\ , Tanya CREATED:20220916T140058Z DESCRIPTION:Yuleika Martinez Castillo is in Chantell Skye Evans Lab. DURATION:PT1H DTSTAMP:20220927T152853Z DTSTART;TZID=America/New_York:20221005T120000 LAST-MODIFIED:20220927T152853Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Mitochondrial quality control in anxiety disorders UID:CAL-8a0183a7-83184018-0183-469a465e-00006ee2demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Yuleika Martinez Castillo X-BEDEWORK-DUKE-SERIES:Neurobiology Student Seminar X-BEDEWORK-SUBMITTEDBY:ts168 for Neurobiology (agrp_SchoolofMedicine_Neuro biology) END:VEVENT BEGIN:VEVENT CATEGORIES:Engineering CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Panel/Seminar/Colloquium CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None X-BEDEWORK-COST:free CREATED:20220629T153802Z DESCRIPTION:Predictive Coding of Natural Self-Motion: Implications for Per ception & Action DURATION:PT1H DTSTAMP:20220906T123951Z DTSTART;TZID=America/New_York:20221006T120000 LAST-MODIFIED:20220906T123951Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Predictive Coding of Natural Self-Motion: Implications for Percept ion & Action UID:CAL-8a039360-81409ef1-0181-b01cbffd-00000ce4demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Panel_Seminar_Colloquium:/us er/public-user/Lectures_Conferences/Panel_Seminar_Colloquium X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Engineering:/user/public-use r/Topics/Engineering X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-CS;X-BEDEWORK-PARAM-DESCRIPTION="/principals/users/agrp_PrattSc hool_BME,/principals/users/agrp_SchoolofMedicine_Neurobiology,/principals /users/agrp_PrattSchool,":Biomedical Engineering (BME)\,Neurobiology\,Pra tt School of Engineering X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=warren.grill@duke.edu:Wa rren Grill\, PhD X-BEDEWORK-SPEAKER:Kathleen Cullen\, Johns Hopkins University X-BEDEWORK-DUKE-SERIES:Duke Seminars in Neural Engineering X-BEDEWORK-LOCATION:Wilkinson Building 132 X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:81 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:434.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Image of Kathleen Cullen\, woman with glasses an d shoulder length hair X-BEDEWORK-SUBMITTEDBY:cmb152 for Duke Institute for Brain Sciences (DIBS) (agrp_InstituteforBrainSciences) X-BEDEWORK-IMAGE:/public/Images/Kathleen Cullen_20220629033802PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/Kathleen Cullen_20220629033802PM-thu mb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=2c918085-6bd28f39-016b-f64ac821-00003e49:Kornbluth\ , Jennifer CREATED:20220804T200221Z DESCRIPTION:Dr. Baier is a German neurobiologist with dual German and US-A merican citizenship. He is Director at the Max Planck Institute of Neurob iology and head of the department Genes - Circuits - Behavior. Baier's re search aims to understand how animal brains convert sensory inputs into b ehavioral responses. DURATION:PT1H DTSTAMP:20221006T140611Z DTSTART;TZID=America/New_York:20221011T120000 LAST-MODIFIED:20221006T140611Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Ruth K. Broad Seminar: Herwig Baier: Neuronal architecture of visi on--the zebrafish perspective UID:CAL-8a018f14-821da122-0182-6a73adae-00000d82demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Herwig Baier\, hosted by Jeremy Kay X-BEDEWORK-DUKE-SERIES:The Ruth K. Broad Foundation Seminar Series on Neur obiology and Disease X-BEDEWORK-SUBMITTEDBY:jas36 for Neurobiology (agrp_SchoolofMedicine_Neuro biology) X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:43 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:396.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Herwig Baier headshot X-BEDEWORK-IMAGE:/public/Images/baier_landscape530x421_20220921072115PM.jp g X-BEDEWORK-THUMB-IMAGE:/public/Images/baier_landscape530x421_2022092107211 5PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a087089-35e3fb8e-0136-59bd57dc-0000557a:Schreiber\ , Tanya CREATED:20220916T145122Z DESCRIPTION:Mariana Holguin Lopez is in Josh Huang Lab. DURATION:PT1H DTSTAMP:20221003T204113Z DTSTART;TZID=America/New_York:20221012T120000 LAST-MODIFIED:20221003T204113Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Student Seminar: Mariana Holguin Lopez: Neurons and microglia\, wh o influences who? UID:CAL-8a0183a7-83184018-0183-46c86a12-000071c6demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Mariana Holguin Lopez X-BEDEWORK-DUKE-SERIES:Neurobiology Student Seminar X-BEDEWORK-SUBMITTEDBY:ts168 for Neurobiology (agrp_SchoolofMedicine_Neuro biology) END:VEVENT BEGIN:VEVENT CATEGORIES:Engineering CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Panel/Seminar/Colloquium CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20221005T161344Z DESCRIPTION:MR Current Density Imaging to Validate Current Flow Simulation s in the Human Brain DURATION:PT1H DTSTAMP:20221005T161344Z DTSTART;TZID=America/New_York:20221013T120000 LAST-MODIFIED:20221005T161344Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:MR Current Density Imaging to Validate Current Flow Simulations in the Human Brain UID:CAL-8a0183a7-83184018-0183-a8eca51b-00001e6ddemobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Panel_Seminar_Colloquium:/us er/public-user/Lectures_Conferences/Panel_Seminar_Colloquium X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Engineering:/user/public-use r/Topics/Engineering X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-CS;X-BEDEWORK-PARAM-DESCRIPTION="/principals/users/agrp_PrattSc hool_BME,/principals/users/agrp_SchoolofMedicine_Neurobiology,/principals /users/agrp_PrattSchool,":Biomedical Engineering (BME)\,Neurobiology\,Pra tt School of Engineering X-BEDEWORK-SPEAKER:Axel Thielscher\, Technical University of Denmark X-BEDEWORK-DUKE-SERIES:Duke Seminars in Neural Engineering X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=warren.grill@duke.edu:Wa rren Grill X-BEDEWORK-SUBMITTEDBY:cmb152 for Duke Institute for Brain Sciences (DIBS) (agrp_InstituteforBrainSciences) END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Panel/Seminar/Colloquium CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20221006T203324Z DESCRIPTION:Abstract: The epigenome underlies cell type and state and in p ost-mitotic neurons\, and it regulates the ability for rapid response to activity. Since neurons exit the cell cycle early in development and are long lived\, remodeling of brain function requires that neurons show tran scriptional plasticity to let then change in function in response to stim uli including psychostimulants and developmental cues. This response is d riven by the epigenomic regulation in a cell-type-specific manner. Many s tudies assessing experience driven genomic responses have been carried ou t in bulk tissues so cell-type-specific genomic responses to stimuli that drive neuronal plasticity remains poorly understood. To understand the e pigenomic and transcriptomic mechanisms driving neuronal plasticity\, her e we study multi-omic genomic data from two contexts in the mouse brain: 1) psychostimulant responses in the nucleus accumbens and 2) the postnata l and postmitotic maturation of developing cerebellar granule neurons. In both systems\, I implemented integrative bioinformatic approaches to pre dict transcription factor (TF) activity in regulating the transcriptome. I elucidated cell-type-specific amphetamine induced transcriptomic respon ses\, identified canonical activity regulated transcription factors regul ating those responses\, and determined collaborators and developmental ta rgets of the Zic family TFs\, revealing novel roles of Zics regulating mi gration and synaptic maturation in CGN development. The studies reveal no vel mechanistic insights into neuronal plasticity in different neuronal c ell types by using integrative computational approaches to model chromati n topology\, chromatin accessibility\, gene expression\, and TF binding.\ n\nMentor: Anne West\, M.D.\, Ph.D. \n\nThis will be a hybrid defense. \n Location: Bryan Research 103 \nZoom Link: https://duke.zoom.us/j/99582336 682?pwd=c0tqMGVEVFB5anVKK2huQUpKSm9iUT09 \nMeeting ID: 995 8233 6682 \nPa sscode: 922162 DURATION:PT1H DTSTAMP:20221007T195705Z DTSTART;TZID=America/New_York:20221013T133000 LAST-MODIFIED:20221007T195705Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Systematic Examination of Epigenomic Regulation of Neuronal Plasti city UID:CAL-8a0183a7-83184018-0183-af00becc-000065a4demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Panel_Seminar_Colloquium:/us er/public-user/Lectures_Conferences/Panel_Seminar_Colloquium X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=monica.franklin@duke.edu :Monica Franklin X-BEDEWORK-SPEAKER:Melyssa Minto\, PhD Candidate X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:26 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:379.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Melyssa Minto X-BEDEWORK-SUBMITTEDBY:jaa94 for Biostatistics and Bioinformatics (agrp_Sc hoolofMedicine_BiostatisticsandBioinformatics) X-BEDEWORK-IMAGE:/public/Images/Minto.Melyssa.r_20221006083324PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/Minto.Melyssa.r_20221006083324PM-thu mb.png X-BEDEWORK-CS;X-BEDEWORK-PARAM-DESCRIPTION="/principals/users/agrp_Schoolo fMedicine_CBB,/principals/users/agrp_SchoolofMedicine,":Computational Bio logy and Bioinformatics (CBB)\,School of Medicine (SOM) END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=2c918085-6bd28f39-016b-f64ac821-00003e49:Kornbluth\ , Jennifer CREATED:20220805T000355Z DESCRIPTION:Dr. Holtzman is currently Professor of Neurology\, scientific director of the Hope Center for Neurological Disorders\, and Associate Di rector of the Knight ADRC. Some of his lab's accomplishments include show ing in part how APOE contributes to AD\, development of biomarkers for AD \, demonstration that synaptic activity and sleep affect Aβ and tau level s in vivo\, describing the effects of APOE\, TREM2\, and microglia on tau -mediated neurodegeneration\, and development of an anti-Aβ antibody in a phase III secondary prevention trial for AD (A4) and an anti-ApoE antibo dy being developed for human trials. DURATION:PT1H DTSTAMP:20221006T140754Z DTSTART;TZID=America/New_York:20221018T120000 LAST-MODIFIED:20221006T140754Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Ruth K. Broad Seminar: David Holtzman: Role of APOE and the immune response in tau-mediated neurodegeneration UID:CAL-8a018f14-821da122-0182-6b50d698-00001495demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:David M. Holtzman\, hosted by Jim McNamara X-BEDEWORK-DUKE-SERIES:The Ruth K. Broad Foundation Seminar Series on Neur obiology and Disease X-BEDEWORK-SUBMITTEDBY:jas36 for Neurobiology (agrp_SchoolofMedicine_Neuro biology) X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:19 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:372.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:David Holtzman headshot X-BEDEWORK-IMAGE:/public/Images/Holtzman Photo4-3_530x398_20220921070917PM .jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/Holtzman Photo4-3_530x398_2022092107 0917PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a087089-35e3fb8e-0136-59bd57dc-0000557a:Schreiber\ , Tanya CREATED:20220916T151152Z DESCRIPTION:Kaitlyn Fouke is in Eva Naumann Lab. DURATION:PT1H DTSTAMP:20221011T184021Z DTSTART;TZID=America/New_York:20221019T120000 LAST-MODIFIED:20221011T184021Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Student Seminar: Kaitlyn Fouke: A Systems Neuroscientist’s Dream: Perturbing functional and circuit dynamics of perception UID:CAL-8a0183a7-83184018-0183-46db2c1a-00007329demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Kaitlyn Fouke X-BEDEWORK-DUKE-SERIES:Neurobiology Student Seminar X-BEDEWORK-SUBMITTEDBY:ts168 for Neurobiology (agrp_SchoolofMedicine_Neuro biology) END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=2c918085-6bd28f39-016b-f64ac821-00003e49:Kornbluth\ , Jennifer CREATED:20220805T000612Z DESCRIPTION:Dr. Hudspeth is interested in the development and regenerative properties of the inner ear's sensory receptors\, the hair cells. Hudspe th and his team investigate the structure and operation of hair cells in the hope of laying the groundwork for an understanding of normal hearing as well as its deterioration and restoration. They employ a variety of ap proaches\, including biophysics\, electrophysiology\, developmental biolo gy\, biochemistry\, genetics\, molecular biology\, immunology\, and ultra structural analysis. In addition\, they assimilate their findings into ma thematical models of hair-cell function. DURATION:PT1H DTSTAMP:20221013T161431Z DTSTART;TZID=America/New_York:20221025T120000 LAST-MODIFIED:20221013T161431Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:CANCELLED: Ruth K. Broad Seminar: Jim Hudspeth: Making an effort t o listen: mechanical amplification by hair cells of the inner ear UID:CAL-8a018f14-821da122-0182-6b52edd6-00001497demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Jim Hudspeth\, hosted by Steve Eliades X-BEDEWORK-DUKE-SERIES:The Ruth K. Broad Foundation Seminar Series on Neur obiology and Disease X-BEDEWORK-SUBMITTEDBY:jas36 for Neurobiology (agrp_SchoolofMedicine_Neuro biology) X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:17 X-BEDEWORK-IMAGE-X2:690 X-BEDEWORK-IMAGE-Y2:477 X-BEDEWORK-IMAGE-CROP-WIDTH:690 X-BEDEWORK-IMAGE-CROP-HEIGHT:460 X-BEDEWORK-IMAGE-ALT-TEXT:Jim Hudspeth headshot X-BEDEWORK-IMAGE:/public/Images/JHudspeth_NeuroSeminarFlyer_crop_202209290 35651PM.png X-BEDEWORK-THUMB-IMAGE:/public/Images/JHudspeth_NeuroSeminarFlyer_crop_202 20929035651PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Medicine CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Conference/Symposium CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a008fe4-7eb28668-017f-569f24cd-0000042e:Perrone\, Maria CREATED:20221003T170043Z DESCRIPTION:The Duke Comprehensive Epilepsy Center (DCEC) is pleased to an nounce our next DCEC Epilepsy Research Symposium\, which will be held Tue sday October 25th\, 2022 at 5:00pm in the Bryan Research Building Auditor ium. This symposium brings together clinical and basic research faculty t o discuss research related to epilepsy.\nThe symposium will feature the f ollowing presentation:\n"Rapid EEG: Historical Overview of Published Evid ence" by Josef Parvizi\, MD\, PhD\nProfessor of Neurology\, Stanford Univ ersity\n\nRSVP Here: https://bit.ly/DCECFall22 DURATION:PT1H30M DTSTAMP:20221003T170144Z DTSTART;TZID=America/New_York:20221025T170000 LAST-MODIFIED:20221003T170144Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:DCEC Research Symposium Fall 2022 UID:CAL-8a0183a7-83184018-0183-9ecaf2ae-00000c3fdemobedework@mysite.edu URL:https://bit.ly/DCECFall22 X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Conference_Symposium:/user/p ublic-user/Lectures_Conferences/Conference_Symposium X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Medicine:/user/public-user/T opics/Medicine X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-CS;X-BEDEWORK-PARAM-DESCRIPTION="/principals/users/agrp_Institu teforBrainSciences,":Duke Institute for Brain Sciences (DIBS) X-BEDEWORK-IMAGE-X1:21 X-BEDEWORK-IMAGE-Y1:11 X-BEDEWORK-IMAGE-X2:755 X-BEDEWORK-IMAGE-Y2:500.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:734 X-BEDEWORK-IMAGE-CROP-HEIGHT:489.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:DCEC Fall 22 X-BEDEWORK-SUBMITTEDBY:mcp59 for Department of Neurology (agrp_SOM_ClinDep _Neurology) X-BEDEWORK-IMAGE:/public/Images/Twitter DCEC Program talk Oct 2022_2022100 3050043PM.png X-BEDEWORK-THUMB-IMAGE:/public/Images/Twitter DCEC Program talk Oct 2022_2 0221003050043PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a087089-35e3fb8e-0136-59bd57dc-0000557a:Schreiber\ , Tanya CREATED:20220916T151349Z DESCRIPTION:Andra "Marija" Rudzite is in Greg Field/Marc Sommer Labs. DURATION:PT1H DTSTAMP:20221018T172552Z DTSTART;TZID=America/New_York:20221026T120000 LAST-MODIFIED:20221018T172552Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Student Seminar: Andra "Marija" Rudzite: Colorful cousin of the si mple cell in macaque V1 UID:CAL-8a0183a7-83184018-0183-46dcf88d-0000732ademobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Andra "Marija" Rudzite X-BEDEWORK-DUKE-SERIES:Neurobiology Student Seminar X-BEDEWORK-SUBMITTEDBY:ts168 for Neurobiology (agrp_SchoolofMedicine_Neuro biology) END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a087089-35e3fb8e-0136-59bd57dc-0000557a:Schreiber\ , Tanya CREATED:20221006T181113Z DESCRIPTION:Women are at twice the risk for anxiety and depression disorde rs as men are\, although the underlying biological factors and mechanisms are largely unknown. In this talk\, Dr. Kundakovic will address this sex disparity at both the etiological and mechanistic level. She will discus s the role of fluctuating ovarian hormones as a critical biological facto r contributing to the increased depression and anxiety risk in women. Cyc ling ovarian hormones drive brain and behavioral plasticity in both human s and rodents\, and the talk will focus on animal studies in Dr. Kundakov ic's lab that are revealing the molecular and receptor mechanisms that un derlie this female-specific brain dynamic. She will highlight a sex hormo ne-driven epigenetic mechanism\, namely chromatin organizational changes\ , that dynamically regulates neuronal gene expression and brain plasticit y but may also prime the (epi)genome for psychopathology. Dr. Kundakovic will also highlight an unconventional role that chromatin dynamics may ha ve in regulating neuronal function across the ovarian cycle\, including i n sex hormone-driven X chromosome plasticity and hormonally-induced epige netic priming. Finally\, she will map out future directions including exp erimental and clinical studies that will facilitate novel sex- and gender -informed approaches to treat depression and anxiety disorders. DURATION:PT1H DTSTAMP:20221006T184908Z DTSTART;TZID=America/New_York:20221101T120000 LAST-MODIFIED:20221006T184908Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Invited Seminar: Marija Kundakovic: Sex-specific chromatin dynamic s in the brain: Implications for anxiety disorders and depression UID:CAL-8a0183a7-83184018-0183-ae7e8fb1-00006096demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Marija Kundakovic X-BEDEWORK-DUKE-SERIES:Neurobiology Seminar Series X-BEDEWORK-SUBMITTEDBY:ts168 for Neurobiology (agrp_SchoolofMedicine_Neuro biology) X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:0 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:353.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Marija Kundakovic headshot X-BEDEWORK-IMAGE:/public/Images/MarijaKundakovic_horiz530_20221006064908PM .jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/MarijaKundakovic_horiz530_2022100606 4908PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a087089-35e3fb8e-0136-59bd57dc-0000557a:Schreiber\ , Tanya CREATED:20220916T151544Z DESCRIPTION:Emily Alway is in Diego Bohorquez Lab. DURATION:PT1H DTSTAMP:20221026T134337Z DTSTART;TZID=America/New_York:20221102T120000 LAST-MODIFIED:20221026T134337Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Student Seminar: Emily Alway: A shocking new role of microglia in compulsive sucrose-seeking UID:CAL-8a0183a7-83184018-0183-46deb976-0000732bdemobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Emily Alway X-BEDEWORK-DUKE-SERIES:Neurobiology Student Seminar X-BEDEWORK-SUBMITTEDBY:ts168 for Neurobiology (agrp_SchoolofMedicine_Neuro biology) END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a087089-35e3fb8e-0136-59bd57dc-0000557a:Schreiber\ , Tanya CREATED:20221006T192341Z DESCRIPTION:By studying electric fish\, Nathaniel Sawtell\, Associate Prof essor of Neuroscience\; Principal Investigator at Columbia's Zuckerman In stitute\, is revealing the brain circuitry that filters our senses\, allo wing us to ignore unimportant information and focus on what matters. DURATION:PT1H DTSTAMP:20221020T144141Z DTSTART;TZID=America/New_York:20221108T120000 LAST-MODIFIED:20221020T144141Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Invited Seminar: Nate Sawtell: Neural Mechanisms for Internal Mode ls: Insights from Electric Fish UID:CAL-8a0183a7-83184018-0183-aec0ea1e-0000625edemobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Nate Sawtell X-BEDEWORK-DUKE-SERIES:Neurobiology Seminar Series X-BEDEWORK-SUBMITTEDBY:ts168 for Neurobiology (agrp_SchoolofMedicine_Neuro biology) END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a087089-35e3fb8e-0136-59bd57dc-0000557a:Schreiber\ , Tanya CREATED:20220916T151754Z DESCRIPTION:Antony "Brayan" Campos Salazar is in Staci Bilbo Lab. DURATION:PT1H DTSTAMP:20221103T135606Z DTSTART;TZID=America/New_York:20221109T120000 LAST-MODIFIED:20221103T135606Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Student Seminar: Antony "Brayan" Campos Salazar: Segregating memor ies in time: The role of an immune molecule in memory linking” UID:CAL-8a0183a7-83184018-0183-46e0b2e3-0000732cdemobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Antony "Brayan" Campos Salazar X-BEDEWORK-DUKE-SERIES:Neurobiology Student Seminar X-BEDEWORK-SUBMITTEDBY:ts168 for Neurobiology (agrp_SchoolofMedicine_Neuro biology) END:VEVENT BEGIN:VEVENT CATEGORIES:Medicine CATEGORIES:Engineering CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Panel/Seminar/Colloquium CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None X-BEDEWORK-COST:free CREATED:20220629T155500Z DESCRIPTION:Dr. Scott Lempka's Neuromodulation Laboratory strives to advan ce neurostimulation therapies for chronic pain and innovate new technolog ies that dramatically improve patients' lives. DURATION:PT1H DTSTAMP:20221028T151455Z DTSTART;TZID=America/New_York:20221110T120000 LAST-MODIFIED:20221028T151455Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Spinal cord stimulation for pain: What we know\, what we don’t kno w\, and why it’s important for modern medicine UID:CAL-8a039360-81409ef1-0181-b02c4a01-00000ce6demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Panel_Seminar_Colloquium:/us er/public-user/Lectures_Conferences/Panel_Seminar_Colloquium X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Engineering:/user/public-use r/Topics/Engineering X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Medicine:/user/public-user/T opics/Medicine X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-CS;X-BEDEWORK-PARAM-DESCRIPTION="/principals/users/agrp_PrattSc hool_BME,/principals/users/agrp_SchoolofMedicine_Neurobiology,/principals /users/agrp_PrattSchool,":Biomedical Engineering (BME)\,Neurobiology\,Pra tt School of Engineering X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=warren.grill@duke.edu:Wa rren Grill\, PhD X-BEDEWORK-SPEAKER:Scott Lempka\, University of Michigan X-BEDEWORK-DUKE-SERIES:Duke Seminars in Neural Engineering X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:79 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:432.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Image of Scott Lempka\, man in suit X-BEDEWORK-SUBMITTEDBY:cmb152 for Duke Institute for Brain Sciences (DIBS) (agrp_InstituteforBrainSciences) X-BEDEWORK-IMAGE:/public/Images/Scott Lempka_20220629035501PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/Scott Lempka_20220629035501PM-thumb. png END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a087089-35e3fb8e-0136-59bd57dc-0000557a:Schreiber\ , Tanya CREATED:20221110T185815Z DESCRIPTION:Na Young Jun is in Greg Field laboratory. DURATION:PT1H DTSTAMP:20221110T185815Z DTSTART;TZID=America/New_York:20221121T130000 LAST-MODIFIED:20221110T185815Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Dissertation Seminar: Na Young Jun: Understanding the Diversity of Retinal Cell Types and Mosaic Organizations through Efficient Coding The ory UID:CAL-8a0183a7-83184018-0184-62e834a7-000035e9demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Na Young Jun X-BEDEWORK-SUBMITTEDBY:ts168 for Neurobiology (agrp_SchoolofMedicine_Neuro biology) END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a087089-35e3fb8e-0136-59bd57dc-0000557a:Schreiber\ , Tanya CREATED:20221110T190112Z DESCRIPTION:Mariah Hazlett is in Anne West Laboratory. DURATION:PT1H DTSTAMP:20221110T190112Z DTSTART;TZID=America/New_York:20221122T130000 LAST-MODIFIED:20221110T190112Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Dissertation Seminar: Mariah Hazlett: Structural\, Functional\, an d Behavioral Outcomes of Stimulus-Dependent Transcription in Nucleus Accu mbens Parvalbumin-Expressing Interneurons UID:CAL-8a0183a7-83184018-0184-62eae877-000035eademobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Mariah Hazlett X-BEDEWORK-SUBMITTEDBY:ts168 for Neurobiology (agrp_SchoolofMedicine_Neuro biology) END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a087089-35e3fb8e-0136-59bd57dc-0000557a:Schreiber\ , Tanya CREATED:20220916T151929Z DESCRIPTION:Ziyi Gong is in Nicolas Brunel Lab. DURATION:PT1H DTSTAMP:20221128T154605Z DTSTART;TZID=America/New_York:20221130T120000 LAST-MODIFIED:20221128T154605Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Student Seminar: Ziyi Gong: Detangling Sensory and Memory Repres entations through Rotational Dynamics UID:CAL-8a0183a7-83184018-0183-46e22758-0000732ddemobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Ziyi Gong X-BEDEWORK-DUKE-SERIES:Neurobiology Student Seminar X-BEDEWORK-SUBMITTEDBY:ts168 for Neurobiology (agrp_SchoolofMedicine_Neuro biology) END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a087089-35e3fb8e-0136-59bd57dc-0000557a:Schreiber\ , Tanya CREATED:20221006T192914Z DESCRIPTION:How do we make sense of the visual world around us? Our brain takes a pattern of photons hitting the retina\, and continually creates a coherent interpretation of what we see - detecting objects and landmarks - rather than just perceiving an array of pixels. This image processing allows us to perform a range of visual tasks\, such as recognizing a frie nd's face\, finding your way to the grocery store\, and catching a frisbe e. However\, how these computational feats are achieved by the neural cir cuitry of the visual system is largely unknown. Furthermore\, visual proc essing does not occur in isolation\, but depends on behavioral state\, ta sk demands\, and interaction with the world.\n\nOur research is focused o n understanding how neural circuits perform the image processing that all ows us to perform complex visual behaviors\, and how these circuits are r efined by development and experience. We use in vivo recording techniques including high-density extracellular recording and widefield / two-photo n imaging\, along with molecular genetic tools to dissect neural circuits . We have also implemented behavioral tasks for mice so we can perform qu antitative psychophysics to measure the animal's perception\, and we use theoretical models to understand general computational principles being i nstantiated. Recently\, we have extended these approaches to study visual perception in the context of natural behaviors and complex environments\ , in an effort to understand how the visual system functions in real-worl d conditions. We are also studying the octopus visual system\, to underst and how a completely different brain architecture processes visual inform ation. DURATION:PT1H DTSTAMP:20221018T204350Z DTSTART;TZID=America/New_York:20221206T120000 LAST-MODIFIED:20221018T204350Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Invited Seminar: Cris Niell: Neural circuits for natural vision UID:CAL-8a0183a7-83184018-0183-aec5ffb2-000062bedemobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Cris Niell X-BEDEWORK-DUKE-SERIES:Neurobiology Seminar Series X-BEDEWORK-SUBMITTEDBY:ts168 for Neurobiology (agrp_SchoolofMedicine_Neuro biology) END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a087089-35e3fb8e-0136-59bd57dc-0000557a:Schreiber\ , Tanya CREATED:20220916T152045Z DESCRIPTION:Tiffany Bokyoung Ko is in Bradley John Goldstein Lab. DURATION:PT1H DTSTAMP:20221201T165521Z DTSTART;TZID=America/New_York:20221207T120000 LAST-MODIFIED:20221201T165521Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Student Seminar: Tiffany Ko: A Stressful Decision: Transforming Ol factory Receptor Choice Into Axon Targeting Specificity UID:CAL-8a0183a7-83184018-0183-46e34ef9-0000732edemobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Tiffany Bokyoung Ko X-BEDEWORK-DUKE-SERIES:Neurobiology Student Seminar X-BEDEWORK-SUBMITTEDBY:ts168 for Neurobiology (agrp_SchoolofMedicine_Neuro biology) END:VEVENT BEGIN:VEVENT CATEGORIES:Diversity/Inclusion CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a087089-35e3fb8e-0136-59bd57dc-0000557a:Schreiber\ , Tanya CREATED:20221202T173345Z DESCRIPTION:Lessons from the Literature: Defining Elements of Inclusive Re search Environments\n\nAbstract: Racial and ethnic minorities comprise on e-third of the U.S. population yet represent only 10% of life science PhD s-and just 5% of tenure-track faculty in the biological sciences. Regardi ng gender\, women of all racial and ethnic backgrounds earn more than hal f of PhD degrees in biomedical sciences yet comprise only 38 percent of f ull-time faculty and 22 percent of tenured faculty. The literature on dis parities in the STEM workforce points to several factors which contribute to inequity from lack of exposure to careers in STEM in early education\ , a scarcity of models of identity\, inequitable access to sociocultural and financial resources\, and bias both implicitly and explicitly at work within the way we identify\, educate\, train\, and support scientists an d scientific research. In light of these barriers\, we must look beyond r ecruitment to effectively advance diversity\, equity\, and inclusion in t he scientific community. In this talk\, I will discuss findings from the literature which highlight systemic and individual elements that can enha nce or inhibit the development of a productive and inclusive research env ironment. DURATION:PT1H DTSTAMP:20221219T153729Z DTSTART;TZID=America/New_York:20221208T120000 LAST-MODIFIED:20221219T153729Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:CANCELLED: EDI Lecture: Johnna Frierson: Lessons from the Literatu re: Defining Elements of Inclusive Research Environments UID:CAL-8a0183a7-83184018-0184-d3e6beb8-00007049demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Diversity/Inclusion:/user/pu blic-user/Topics/Diversity_Inclusion X-BEDEWORK-SPEAKER:Johnna Frierson X-BEDEWORK-SUBMITTEDBY:ts168 for Neurobiology (agrp_SchoolofMedicine_Neuro biology) END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20221021T130955Z DESCRIPTION:Programmable genome and epigenetic editing platforms have chan ged how we do research today while providing enormous therapeutic potenti al. The domains that were initially used for these purposes\, Cys2His2 zi nc fingers and homing endonucleases\, were difficult to engineer and offe red inconsistent efficacy. Not surprisingly\, these platforms were quickl y replaced by TALE and CRISPR systems due to their high activity and extr eme ease of use. However\, a zinc finger design code would provide therap eutic advantages such as smaller size for routine AAV delivery and reduce d immunogenic risk\, while providing a better approximation of natural tr anscription factor function for academic applications. Therefore\, to ove rcome the limitations of zinc finger design we have spent nearly a decade evolving zinc fingers in different adjacent finger contexts to provide a detailed understanding of both specificity and domain compatibility. We used the screen of 28 libraries and over 114 billion protein-DNA interact ions to provide the data necessary to train an AI-based model of zinc fin ger specificity and array design. We have applied this model to simply de sign zinc finger arrays that can be used as nucleases\, activators\, and repressors with similar activity to alternative platforms. This model rep resents a solution to a 30-year design challenge for the routine producti on of highly active zinc finger arrays! \n \nZinc fingers are the most co mmon DNA-binding domain utilized by eukaryotic transcription factors\, re presenting roughly 50% of the human transcription factors. Therefore\, we reasoned that our design model could be used to commandeer the natural f unctions of these transcription factors. We have applied our model to a s eries of human transcription factors and seamlessly reprogrammed their DN A-binding domains while keeping the rest of the protein intact. In all ca ses this approach has allowed us to direct the transcription factor's fun ction to novel sequences across the genome. This transcription factor rep rogramming enables the targeting of activation\, repression\, or both to any sequences in the genome. As these factors are small enough that sever al are able to be packed into a single AAV cassette\, reprogrammed transc ription factors provide robust tools for multiplexed epigenetic editing w ith proteins completely composed of human components. DURATION:PT1H DTSTAMP:20221021T130955Z DTSTART;TZID=America/New_York:20221212T100000 LAST-MODIFIED:20221021T130955Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Reprogramming Human Transcription Factors for Epigenetic Editing UID:CAL-8a0183a7-83184018-0183-faaa1cc1-00004731demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-CS;X-BEDEWORK-PARAM-DESCRIPTION="/principals/users/agrp_AGPM_Co llaboratory,":Precision Genomics Collaboratory X-BEDEWORK-SPEAKER:Marcus Noyes X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=michael.humphreys@duke.e du:Michael Humphreys X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:-0.3333333333333144 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:353 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Marcus Noyes X-BEDEWORK-SUBMITTEDBY:ak431 for Center for Advanced Genomic Technologies (agrp_Pratt_CAGT) X-BEDEWORK-IMAGE:/public/Images/marcus noyes calendar_20221021010955PM.png X-BEDEWORK-THUMB-IMAGE:/public/Images/marcus noyes calendar_20221021010955 PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=2c918085-6ae23b32-016b-056224ee-000029ee:McKee\, Am y CREATED:20221111T150309Z DESCRIPTION:Join us for a talk by Elly Tanaka\, PhD\, of Research Institut e of Molecular Pathology\, Vienna\, Austria titled:"Appendage regeneratio n as a model to understand growth and pattern control in the adult contex t" DURATION:PT2H DTSTAMP:20221111T162656Z DTSTART;TZID=America/New_York:20221212T160000 LAST-MODIFIED:20221111T162656Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Duke Regeneration Center Special Seminar UID:CAL-8a0183a7-83184018-0184-673754f3-00005395demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-CS;X-BEDEWORK-PARAM-DESCRIPTION="/principals/users/agrp_Centerf orAgingandHumanDevelopment,":Center for Aging and Human Development X-BEDEWORK-SPEAKER:Elly Tanaka\, PhD X-BEDEWORK-IMAGE-X1:48 X-BEDEWORK-IMAGE-Y1:0 X-BEDEWORK-IMAGE-X2:577.5 X-BEDEWORK-IMAGE-Y2:353 X-BEDEWORK-IMAGE-CROP-WIDTH:529.5 X-BEDEWORK-IMAGE-CROP-HEIGHT:353 X-BEDEWORK-IMAGE-ALT-TEXT:Elly Tanaka talk flier X-BEDEWORK-SUBMITTEDBY:am465 for Duke Regeneration Center (agrp_SchoolofMe dicine_RegenerationNext) X-BEDEWORK-IMAGE:/public/Images/Slide2_20221111042513PM.jpeg X-BEDEWORK-THUMB-IMAGE:/public/Images/Slide2_20221111042513PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a087089-35e3fb8e-0136-59bd57dc-0000557a:Schreiber\ , Tanya CREATED:20221006T193256Z DESCRIPTION:Dopamine regulates multiple brain functions including learning \, motivation\, and movement. Furthermore\, the striatum\, a major target of dopamine neurons\, is parceled into multiple subregions that are asso ciated with different types of behavior\, such as Pavlovian\, goal-direct ed\, and habitual behaviors. An important question in the field is how do pamine regulates these diverse functions. It has been thought that midbra in dopamine neurons broadcast a reward prediction error signal to facilit ate associative learning. However\, recent studies have found more divers e dopamine signals than originally thought. How can we reconcile these re sults? In this talk\, I will discuss our recent studies characterizing di verse dopamine signals\, and how these findings can be understood in theo retical frameworks. DURATION:PT1H DTSTAMP:20221213T173037Z DTSTART;TZID=America/New_York:20221213T120000 LAST-MODIFIED:20221213T173037Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Duke Neurobiology Invited Seminar: Nao Uchida: Diversity of dopami ne neurons: toward a normative perspective UID:CAL-8a0183a7-83184018-0183-aec962b0-000062bfdemobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Nao Uchida X-BEDEWORK-DUKE-SERIES:Neurobiology Seminar Series X-BEDEWORK-SUBMITTEDBY:ts168 for Neurobiology (agrp_SchoolofMedicine_Neuro biology) END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a087089-35e3fb8e-0136-59bd57dc-0000557a:Schreiber\ , Tanya CREATED:20221107T155250Z DESCRIPTION:The McBride lab takes advantage of evolution in natural mosqui to populations to understand the genomic and neuronal basis of behavior a nd the molecular mechanisms by which behaviors evolve. DURATION:PT1H DTSTAMP:20221213T173058Z DTSTART;TZID=America/New_York:20230110T120000 LAST-MODIFIED:20221213T173058Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Duke Neurobiology Invited Seminar: Lindy McBride: Evolution of odo r coding and circuits in a human-biting mosquito UID:CAL-8a0183a7-83184018-0184-52cb60c0-00001d7cdemobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Lindy McBride X-BEDEWORK-DUKE-SERIES:Neurobiology Seminar Series X-BEDEWORK-SUBMITTEDBY:ts168 for Neurobiology (agrp_SchoolofMedicine_Neuro biology) END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a087089-35e3fb8e-0136-59bd57dc-0000557a:Schreiber\ , Tanya CREATED:20221107T155530Z DESCRIPTION:The prefrontal cortex (PFC) has been dubbed the "doer cortex" with a primary role of representing and selecting purposeful actions. In the context of psychiatric disorders\, much of the neuronal data and com putational work on the PFC encoding of behavior focuses on the representa tion (or perception) of internal and external events that precede these a ctions. We have been interested in the encoding of goal-directed actions per se by PFC neurons and how it is affected by anxiety. The focus on anx iety stems from the fact that its relevance to mental health extends well beyond anxiety disorders. Critically\, anxiety is a debilitating symptom of most psychiatric disorders including PTSD\, major depression\, autism \, schizophrenia and addiction. Anxiety is often studied as a stand-alone construct in laboratory animals that focuses on fear responses. But in t he context of coping with real-life anxiety\, its negative impacts extend beyond aversive feelings to involve disruptions in ongoing goal-directed behaviors and cognitive functioning. I will present data from two distin ct models of anxiety that allowed us to perform ensemble and local field potential recordings during reward-guided goal-directed behaviors. We fi nd that anxiety diminishes the recruitment of action encoding neurons and the coordinated activity between PFC and dopamine neurons. These results provide mechanistic insight for how anxiety diminishes rule-based guidan ce of behavior and single out encoding of actions\, as opposed to cues or outcomes\, by PFC neurons as particularly vulnerable to anxiety. DURATION:PT1H DTSTAMP:20221215T170004Z DTSTART;TZID=America/New_York:20230117T120000 LAST-MODIFIED:20221215T170004Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Duke Neurobiology Invited Seminar: Bita Moghaddam: Translation of anxiety into actions by prefrontal cortex neurons UID:CAL-8a0183a7-83184018-0184-52cdce95-00001d7ddemobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Bita Moghaddam X-BEDEWORK-DUKE-SERIES:Neurobiology Seminar Series X-BEDEWORK-SUBMITTEDBY:ts168 for Neurobiology (agrp_SchoolofMedicine_Neuro biology) END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a0870ef-4aa48edb-014a-c44ac365-0000451d:Massard\, Pat CREATED:20221221T162938Z DESCRIPTION:*** Talk has been rescheduled to Tuesday\, January 31\, from 1 :30-2:30pm in 103 Bryan. ***\n\nContact Greg Crawford (greg.crawford at d uke dot edu) and Debby Silver (debra.silver at duke dot edu) with any que stions. DURATION:PT1H DTSTAMP:20230118T191626Z DTSTART;TZID=America/New_York:20230117T133000 LAST-MODIFIED:20230118T191626Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:RESCHEDULED TO 1/31: Neuroimmune Interactions in Alzheimer’s Disea se and Aging UID:CAL-8a0183a7-83184018-0185-3584dfd3-000029fademobedework@mysite.edu URL:http://calendar.duke.edu/show?fq=id%3ACAL-8a0290cd-85a68f68-0185-c57f6 fb6-00004b73demobedework%40mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-CS;X-BEDEWORK-PARAM-DESCRIPTION="/principals/users/agrp_Pratt_C AGT,":Center for Advanced Genomic Technologies X-BEDEWORK-SPEAKER:Michael Haney\, PhD X-BEDEWORK-DUKE-SERIES:CAGT/MGM Faculty Recruit Seminar X-BEDEWORK-SUBMITTEDBY:pam29 for Molecular Genetics and Microbiology (MGM) (agrp_SchoolofMedicine_MolecularGenetics) X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:-0.3333333333333144 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:353 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Michael Haney\, PhD X-BEDEWORK-IMAGE:/public/Images/Michael-Haney_20230118071626PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/Michael-Haney_20230118071626PM-thumb .png END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a087089-35e3fb8e-0136-59bd57dc-0000557a:Schreiber\ , Tanya CREATED:20230105T191209Z DESCRIPTION:Even under the most controlled stimulus conditions\, an identi cal sensory stimulus will evoke different spiking responses each time it is presented within a cortical neuron's receptive field. Understanding th e sources\, nature\, and consequences of neural response variability is c ritical to understanding how the brain processes sensory information. Spi ke variability is not due to noise in the spiking mechanism itself as neu rons in vitro can emit nearly identical spike trains when stimulated with identical fluctuating currents. Rather\, a major source of variability i s fluctuations in synaptic activity arriving through the highly recurrent organization of the cortical networks in which each neuron is embedded. Using newly developed techniques to characterize the moment-to-moment dyn amics of noisy multi-electrode data recorded from Area MT in common marmo sets\, we find the functional organization of cortical networks gives ris e to intrinsic traveling waves (iTWs) of cortical activity. These waves r egulate both the gain of stimulus-evoked spiking responses and the monkey 's perceptual sensitivity during a visual detection task. In a large-scal e spiking network model we find that iTWs naturally emerge from propagati on delays in topographically organized recurrent connections similar to t he horizontal fibers in cortex. The model predicts that iTWs are sparse\, in the sense that only a small fraction of the neural population partici pates in any individual iTW. As a result\, iTWs can occur without inducin g correlated variability\, which can impair sensory discrimination. The m odel also predicts\, based on horizontal fiber connectivity principles\, that iTWs fall into feature-selective motifs whose selectivity stems from the preference for connections among similarly tuned feature domains. Co nsistent with this prediction\, we find wave motifs that modulate both ne ural activity and perceptual sensitivity in a feature-selective manner. T aken together\, these findings suggest that traveling waves may reflect t he inferential nature of sensory processing whereby intrinsic network act ivity shapes weak or ambiguous sensory input to construct our percept of the external world. DURATION:PT1H DTSTAMP:20230105T191209Z DTSTART;TZID=America/New_York:20230119T140000 LAST-MODIFIED:20230105T191209Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Neurobiology Faculty Candidate Talk: Zac Davis: Intrinsic cortical network activity shapes sensory input to build perceptual inferences UID:CAL-8a0183a7-83184018-0185-83590e77-00000fe1demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Zac Davis X-BEDEWORK-SUBMITTEDBY:ts168 for Neurobiology (agrp_SchoolofMedicine_Neuro biology) END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a087089-35e3fb8e-0136-59bd57dc-0000557a:Schreiber\ , Tanya CREATED:20230105T191419Z DESCRIPTION:Every day\, we make decisions based on expected outcomes\, fro m choosing what to eat for breakfast to deciding whether to travel during a pandemic. While there is emerging evidence for sex differences in this decision-making behavior\, the neural substrates underlying these differ ences remain largely unknown. I will present my postdoctoral work demonst rating that while male and female mice make similar choices in a value-ba sed decision-making task\, their motivation to engage in the task differs . Specifically\, task engagement is more strongly modulated by action val ue in females than in males. Additionally\, we identified a sex-dependent role for the neurons that project from the anterior cingulate cortex to the dorsomedial striatum in the regulation of motivation. Inhibition of t hese neurons disrupts the relationship between value and motivation in fe males\, without affecting choice in either sex. Consistently\, in females compared to males\, these neurons have stronger representations of negat ive outcome and low chosen value. Finally\, I will discuss my future rese arch plan\, which uses naturalistic decision-making paradigms to disentan gle how information necessary for value-based choice is processed in larg e-scale cortico-subcortical circuits to reveal the neural computations un derlying value-based decision making. DURATION:PT1H DTSTAMP:20230105T191419Z DTSTART;TZID=America/New_York:20230123T120000 LAST-MODIFIED:20230105T191419Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Neurobiology Faculty Candidate Talk: Julia Cox: A neural substrate of sex-dependent modulation of motivation UID:CAL-8a0183a7-83184018-0185-835b09ce-00000fe2demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Julia Cox X-BEDEWORK-SUBMITTEDBY:ts168 for Neurobiology (agrp_SchoolofMedicine_Neuro biology) END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a087089-35e3fb8e-0136-59bd57dc-0000557a:Schreiber\ , Tanya CREATED:20221107T155806Z DESCRIPTION:Abstract: Animals perform specific behaviors in response to sp ecific sensory information from their environment. Yet\, similar sensory stimuli can trigger distinct behaviors depending on the context\, a proce ss known as "action selection". How animals select which context-dependen t behavior to perform? We examined this question in the nematode C. elega ns. C. elegans can learn to prefer a temperature\, and when in a gradient \, will move across the gradient towards their preferred temperature (a b ehavior known as gradient migration). Upon encountering their preferred t emperature\, they switch their behavioral strategy to track the temperatu re (a behavior known as isothermal tracking). From forward genetic screen s we uncovered a role for the innexin/inx-1 gene in action selection duri ng thermotaxis: mutants for inx-1 display reduced gradient migration and abnormally perform isothermal tracking at incorrect temperatures. We disc overed that inx-1 is specifically required in the AIY interneurons\, a pa ir of first-layer interneurons of the thermotaxis circuit. Inx-1 forms an electrical synapse that couples the bilaterally symmetric AIY interneuro ns. The coupling of the interneurons reduces input resistance and excitab ility\, altering sensory information processing. The AIY interneurons con trol persistent forward movement in response to a stimulus\, and their re duced excitability affects persistence of thermotaxis behavior as it sens es temperature changes in the gradient\, and thereby\, action selection i n response to specific temperatures. Our findings identify a specific rol e for electrical synapses in sustaining electrophysiological circuit prop erties that then enable context-dependent action selection based on exper ience. DURATION:PT1H DTSTAMP:20230105T142307Z DTSTART;TZID=America/New_York:20230124T120000 LAST-MODIFIED:20230105T142307Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Duke Neurobiology Invited Seminar: Daniel Colon-Ramos: Electrical synapses create a high-pass filter to modulate sensory information proces sing and action selection in C. elegans UID:CAL-8a0183a7-83184018-0184-52d03287-00001d7edemobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Daniel Colon Ramos X-BEDEWORK-DUKE-SERIES:Neurobiology Seminar Series X-BEDEWORK-SUBMITTEDBY:ts168 for Neurobiology (agrp_SchoolofMedicine_Neuro biology) END:VEVENT BEGIN:VEVENT CATEGORIES:Engineering CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Panel/Seminar/Colloquium CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a0183a7-83184018-0184-7f48ca2e-00001fd0:Vahaba\, D aniel CREATED:20221031T140443Z DESCRIPTION:The Center for Neural Engineering & Neurotechnology focuses on using engineering techniques to understand the mechanisms of and develop advanced approaches to electrical stimulation of the nervous system to r estore function to individuals with neurological impairment or injury. DURATION:PT1H DTSTAMP:20230112T152429Z DTSTART;TZID=America/New_York:20230126T120000 LAST-MODIFIED:20230112T152429Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Duke Seminars in Neural Engineering: " Enhancing Rehabilitation wi th Vagus Nerve Stimulation" UID:CAL-8a0183a7-83184018-0184-2e5be0e2-00002a51demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Panel_Seminar_Colloquium:/us er/public-user/Lectures_Conferences/Panel_Seminar_Colloquium X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Engineering:/user/public-use r/Topics/Engineering X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-CS;X-BEDEWORK-PARAM-DESCRIPTION="/principals/users/agrp_PrattSc hool_BME,/principals/users/agrp_SchoolofMedicine_Neurobiology,/principals /users/agrp_PrattSchool,":Biomedical Engineering (BME)\,Neurobiology\,Pra tt School of Engineering X-BEDEWORK-SPEAKER:Seth Hayes (University of Texas\, Dallas) X-BEDEWORK-DUKE-SERIES:Duke Seminars in Neural Engineering X-BEDEWORK-SUBMITTEDBY:cmb152 for Duke Institute for Brain Sciences (DIBS) (agrp_InstituteforBrainSciences) X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:17 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:370.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Image of Seth Hays\, white man with dark hair\, blue eyes\, beard stubble and a blue shirt X-BEDEWORK-IMAGE:/public/Images/SETH-HAYS-1_20221031023230PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/SETH-HAYS-1_20221031023230PM-thumb.p ng END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a087089-35e3fb8e-0136-59bd57dc-0000557a:Schreiber\ , Tanya CREATED:20230105T191612Z DESCRIPTION:Cognitive functions are the result of the coordinated action o f neuronal populations organized within\, and across brain regions. The g oal of my research is to uncover how these populations interact to form s pecialized brain circuits\, and how imbalances in these circuits can resu lt in pathological states. My work\, to date\, has primarily focused on t he architecture and function of local circuits in the hippocampus\, a reg ion critically involved in memory and navigation. \nDuring spatial behavi ors\, individual hippocampal pyramidal cells\, known as 'place cells'\, a re selectively active at specific locations along the animal's trajectory . Populations of place cells collectively form a representation of the en vironment\, providing a substrate thought to support spatial learning and navigation. While these patterns of activity have been extensively descr ibed\, in particular in hippocampal area CA1\, we still lack a mechanisti c understanding of how the spatial selectivity of individual neurons emer ge from local circuit structure\, and how responses are coordinated to pr oduce behaviorally-relevant representations at the population level. \nHe re\, I will present my recent work\, as well as the novel experimental ap proaches used to examine the fine-scale organization of CA1 circuits in b ehaving mice. I will discuss how CA1 may intrinsically support the format ion of cell assemblies\, manifesting as strong interactions between excit atory neurons\, which can be manipulated to enhance spatial learning perf ormance. I will show that these dynamics are extensively regulated by var ious subpopulations of local inhibitory interneurons\, whose distinct fun ctions are now being delineated in the behaving animal. Building upon thi s work\, my future research program will determine the mechanisms by whic h spatial representations of the hippocampus are read\, utilized\, and tr ansformed in downstream regions involved in executive functions and long- term memory storage\, to effectively support complex navigational behavio rs DURATION:PT1H DTSTAMP:20230105T191612Z DTSTART;TZID=America/New_York:20230126T140000 LAST-MODIFIED:20230105T191612Z LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res earch 103 STATUS:CONFIRMED SUMMARY:Neurobiology Faculty Candidate Talk: Tristan Geiller: Organization and function of local hippocampal circuits for navigation UID:CAL-8a0183a7-83184018-0185-835cc5a6-00000fe3demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Tristan Geiller X-BEDEWORK-SUBMITTEDBY:ts168 for Neurobiology (agrp_SchoolofMedicine_Neuro biology) END:VEVENT END:VCALENDAR