BEGIN:VCALENDAR PRODID:BedeWork V3.5 VERSION:2.0 METHOD:PUBLISH BEGIN:VTIMEZONE TZID:America/New_York X-LIC-LOCATION:America/New_York BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:20070311T020000 RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=2SU END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 TZNAME:EST DTSTART:20071104T020000 RRULE:FREQ=YEARLY;BYMONTH=11;BYDAY=1SU END:STANDARD BEGIN:STANDARD TZOFFSETFROM:-045602 TZOFFSETTO:-0500 TZNAME:EST DTSTART:18831118T120358 RDATE:18831118T120358 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:19180331T020000 RDATE:19180331T020000 RDATE:19190330T020000 RDATE:19200328T020000 RDATE:19210424T020000 RDATE:19220430T020000 RDATE:19230429T020000 RDATE:19240427T020000 RDATE:19250426T020000 RDATE:19260425T020000 RDATE:19270424T020000 RDATE:19280429T020000 RDATE:19290428T020000 RDATE:19300427T020000 RDATE:19310426T020000 RDATE:19320424T020000 RDATE:19330430T020000 RDATE:19340429T020000 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RDATE:19841028T020000 RDATE:19851027T020000 RDATE:19861026T020000 RDATE:19871025T020000 RDATE:19881030T020000 RDATE:19891029T020000 RDATE:19901028T020000 RDATE:19911027T020000 RDATE:19921025T020000 RDATE:19931031T020000 RDATE:19941030T020000 RDATE:19951029T020000 RDATE:19961027T020000 RDATE:19971026T020000 RDATE:19981025T020000 RDATE:19991031T020000 RDATE:20001029T020000 RDATE:20011028T020000 RDATE:20021027T020000 RDATE:20031026T020000 RDATE:20041031T020000 RDATE:20051030T020000 RDATE:20061029T020000 END:STANDARD BEGIN:STANDARD TZOFFSETFROM:-0500 TZOFFSETTO:-0500 TZNAME:EST DTSTART:19200101T000000 RDATE:19200101T000000 RDATE:19420101T000000 RDATE:19460101T000000 RDATE:19670101T000000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EWT DTSTART:19420209T020000 RDATE:19420209T020000 END:DAYLIGHT BEGIN:DAYLIGHT TZOFFSETFROM:-0400 TZOFFSETTO:-0400 TZNAME:EPT DTSTART:19450814T190000 RDATE:19450814T190000 END:DAYLIGHT END:VTIMEZONE BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20221028T144225Z DESCRIPTION:"Seeing through cataract formation with NMR spectroscopy"\n\nT he optical power of the vertebrate eye lens is generated by the crystalli ns\, exceptionally soluble proteins that are packed in at very high conce ntration (up to about 50% protein in humans\, and even higher in fish). T he extraordinary solubility of these proteins is even more remarkable giv en that the lens has almost no protein turnover: crystallin proteins have to last for a lifetime. When crystallins do aggregate\, the result is ca taract\, a major cause of blindness worldwide. Understanding both the tra nsparent hydrogel of the healthy lens and the aggregates of the disease s tate is a long-term research direction for my group. I will present our r ecent structural and biophysical work on mutations involved in hereditary cataract\, the impact of oxidative damage\, and the complex relationship among different types of post-translational modifications. I will also d iscuss the NMR instrumentation we have developed to study semi-solid prot ein systems of this type that are not amenable to either standard solid-s tate or solution techniques.\n\nTo learn more about the Martin lab and th eir research\, please visit: https://probemonkey.com/.\n\nFaculty Host: P rof. Warren Warren DURATION:PT1H DTSTAMP:20230324T152639Z DTSTART;TZID=America/New_York:20230404T114000 LAST-MODIFIED:20230324T152639Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Rachel Martin: "Seeing throug h cataract formation with NMR spectroscopy" UID:CAL-8a0183a7-83184018-0184-1f0b50b3-0000543ademobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che mistry Department X-BEDEWORK-SPEAKER:Prof. Rachel Martin\, University of California at Irvin e X-BEDEWORK-DUKE-SERIES:Chemistry Department Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:125 X-BEDEWORK-IMAGE-X2:546 X-BEDEWORK-IMAGE-Y2:489 X-BEDEWORK-IMAGE-CROP-WIDTH:546 X-BEDEWORK-IMAGE-CROP-HEIGHT:364 X-BEDEWORK-IMAGE-ALT-TEXT:Prof. Rachel Martin X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/Martin\,-Rachel_20221028024225PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/Martin\,-Rachel_20221028024225PM-thu mb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20220818T214749Z DESCRIPTION:"Polariton Chemistry: Challenges and Prospects"\n\nThe strong coupling of molecular transitions to photonic modes in optical microcavit ies gives rise to hybrid light-matter modes known as polaritons. In recen t years\, there has been much interest in polariton chemistry\, namely\, the use of polaritons to control chemical and material properties and pro cesses. However\, the mechanisms whereby polaritons can control chemistry are still rather opaque. In this talk\, I will discuss the "large N prob lem" in polariton chemistry\, where the formation of two polariton modes occurs at the expense of having N-1~〖10〗^6-〖10〗^12 dark modes which under many circumstances have similar behavior as bare molecular excitations. I will showcase a class of models that benefit from the existence of pola ritons even at thermal equilibrium and offer some hypotheses about what m ight be happening in experiments.\n\nNext\, I will discuss strategies to ameliorate the large N problem by using concepts of (a) cavity optomechan ics\, (b) polariton condensates\, and (c) non-equilibrium initialization of polaritons. In particular\, I will emphasize a powerful and elegant co mputational tool that we have recently developed to efficiently simulate the polariton chemistry problem\, and showcase interesting experimental s cenarios of polariton mediated photophysics and photochemistry where thes e tools offer tremendous insights.\n\n\nTo learn more about the Yuen-Zhou lab and their research\, please visit: \nhttps://www-chem.ucsd.edu/facul ty/profiles/yuen_zhou_joel.html\n\nFaculty Host: Prof. Weitao Yang DURATION:PT1H30M DTSTAMP:20230320T185704Z DTSTART;TZID=America/New_York:20230406T114000 LAST-MODIFIED:20230320T185704Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Joel Yuen-Zhou: "Polariton Ch emistry: Challenges and Prospects" UID:CAL-8a0183a7-83184018-0185-1bf48637-00005901demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Dep artment of Chemistry X-BEDEWORK-SPEAKER:Prof. Joel Yuen-Zhou\, University of California\, San D iego X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:24 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:377.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT: Prof. Joel Yuen-Zhou X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-DUKE-SERIES:Chemistry Department Seminar Series X-BEDEWORK-IMAGE:/public/Images/06122020--joel-vert 2_20221216052928PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/06122020- -joel-vert 2_2022121605292 8PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20220912T135937Z DESCRIPTION:"Chemical Engineering Approaches for Catalytic Reduction of CO 2"\n\nConverting CO2 to value-added chemicals and fuels is one of the mos t practical routes for reducing CO2 emissions while fossil fuels continue to dominate the energy sector in the near future. In this talk we will present several routes in catalytic CO2 conversion: (1) CO2 hydrogenation by thermocatalysis\, (2) CO2 reduction by electrocatalysis\, and (3) sim ultaneous upgrading of CO2 and shale gas. We will use these examples to h ighlight the importance of combining kinetic studies\, in situ characteri zation and density functional theory calculations for the mechanistic und erstanding of CO2 conversion. We will use the hydrogenation of CO2 to me thanol as an example to illustrate challenges in achieving a net-reductio n of CO2 by performing mass and energy balance analysis. We will also de monstrate proof-of-principle results of several promising catalytic react ions using tandem processes to convert CO2 and light alkanes to syngas\, olefins\, aromatics and oxygenates. \n\nJingguang Chen is the Thayer Lind sley Professor of Chemical Engineering at Columbia University\, with a jo int appointment at Brookhaven National Laboratory. He started his academ ic career at the University of Delaware and rose to the rank of the Clair e LeClaire Professor of chemical engineering and the Director of the Cent er for Catalytic Science and Technology. He is the co-author of 23 Unite d States patents and 475 journal publications\, and he is recognized as a Web of Science Highly Cited Researcher. He is currently the President of the North American Catalysis Society\, the Director of the Synchrotron C atalysis Consortium\, and an Associate Editor of ACS Catalysis. He receiv ed many catalysis awards\, including the George Olah Award on Hydrocarbon /Petroleum Chemistry from the American Chemical Society and the R.H. Wilh elm Award on Chemical Reaction Engineering from the American Institute of Chemical Engineers\n\nTo learn more about the Chen lab and their researc h\, please visit: https://www.cheme.columbia.edu/faculty/jingguang-chen\n \nFaculty Host: Prof. Ivan Moreno-Hernandez DURATION:PT1H DTSTAMP:20230202T211137Z DTSTART;TZID=America/New_York:20230411T114000 LAST-MODIFIED:20230202T211137Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Jingguang Chen: "Chemical Eng ineering Approaches for Catalytic Reduction of CO2" UID:CAL-8a0183a7-83184018-0183-31ff9a0f-000049fademobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Dep artment of Chemistry X-BEDEWORK-SPEAKER:Prof. Jingguang Chen\, Columbia University X-BEDEWORK-DUKE-SERIES:Chemistry Department Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:636 X-BEDEWORK-IMAGE-X2:2106 X-BEDEWORK-IMAGE-Y2:2040 X-BEDEWORK-IMAGE-CROP-WIDTH:2106 X-BEDEWORK-IMAGE-CROP-HEIGHT:1404 X-BEDEWORK-IMAGE-ALT-TEXT:Prof. Jingguang Chen\, Columbia University X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/Chen_Jingguang_20220912015937PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/Chen_Jingguang_20220912015937PM-thum b.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20221028T144945Z DESCRIPTION:"Theoretical Investigation of Exciton Dynamics and Spectroscop y in Natural and Synthetic Light Harvesting Complexes"\n\nTo learn more a bout the Jang lab and their research\, please visit: http://chem.qc.cuny. edu/~sjjang/index.html.\n\nFaculty Host: David Beratan DURATION:PT1H DTSTAMP:20230418T144043Z DTSTART;TZID=America/New_York:20230418T114000 LAST-MODIFIED:20230418T144043Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Seogjoo Jang: "Theoretical In vestigation of Exciton Dynamics and Spectroscopy in Natural and Synthetic Light Harvesting Complexes" UID:CAL-8a0183a7-83184018-0184-1f120714-00005616demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che mistry Department X-BEDEWORK-SPEAKER:Prof. Seogjoo Jang of Queens College of the City Univer sity of New York (CUNY) X-BEDEWORK-DUKE-SERIES:Chemistry Department Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:67 X-BEDEWORK-IMAGE-X2:677 X-BEDEWORK-IMAGE-Y2:518.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:677 X-BEDEWORK-IMAGE-CROP-HEIGHT:451.33333333333326 X-BEDEWORK-IMAGE-ALT-TEXT:Prof. Prof. Seogjoo Jang of Queens College of th e City University of New York (CUNY) X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/SeogjooJang_20221028024945PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/SeogjooJang_20221028024945PM-thumb.p ng END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20230124T181959Z DESCRIPTION:"Electron-Vibrational Coupling in and beyond The Phonon Pictur e:\nConcepts and Applications to Thermal and Electrical Conductivity"\n\n Strong anharmonicity and its critical effect on materials properties are more frequent than typically presumed. Thus\, for many materials and real istic temperatures the phonon picture and with that all phonon-based theo ries break down\, so that an explicit treatment of the nuclear motion in terms of ab initio molecular dynamics becomes decisive for the descriptio n and understanding of many fundamental material properties\, including t hermal and electrical conductivities. \nIn this talk we present a high-th roughput search for thermal insulators employing a hierarchical workflow. It starts with a new anharmonicity measure that allows to rapidly cover thousands of materials so to single out potentially good candidates. The thermal conductivity of the 40 most promising compounds is then calculate d with the ab initio Green-Kubo formalism\, which accounts for anharmonic ity to all orders.\nMoreover\, we use the SISSO method to build an accura te\, interpretable artificial-intelligence model for the lattice thermal conductivity\, so to further accelerate material space exploration. By th is means\, we are able to identify several materials with ultra-low condu ctivity at room temperature. We analyze the actuating mechanisms that hin der heat transport in these materials\, which in turn sheds light on the microscopic origin of strongly anharmonic effects. In particular\, this d emonstrates that energetically barely accessible defect configurations ca n induce a breakdown of the phonon picture. Eventually\, we discuss how t hese anharmonic effects also influence the vibronic coupling to electroni c degrees of freedom and discuss how this affects the electrical conducti vity of strongly anharmonic systems. DURATION:PT1H DTSTAMP:20230207T030738Z DTSTART;TZID=America/New_York:20230420T114000 LAST-MODIFIED:20230207T030738Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar presented by Prof. Matthias Scheffler: "Electron -Vibrational Coupling in and beyond The Phonon Picture: Concepts and Appl ications to Thermal and Electrical Conductivity" UID:CAL-8a0290cd-85a68f68-0185-e50220cc-000040f4demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che mistry Department X-BEDEWORK-SPEAKER:Prof. Matthias Scheffler\, The NOMAD Laboratory at the FHI of the Max-Planck-Gesellschaft X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.33333333333326 X-BEDEWORK-IMAGE-ALT-TEXT:Prof. Matthias Scheffler X-BEDEWORK-IMAGE-Y1:243 X-BEDEWORK-IMAGE-Y2:596.3333333333333 X-BEDEWORK-CS;X-BEDEWORK-PARAM-DESCRIPTION="/principals/users/agrp_Institu tes_MaterialsScienceandEngineering,":Duke Materials Initiative X-BEDEWORK-IMAGE:/public/Images/Scheffler_20230207030738AM.png X-BEDEWORK-THUMB-IMAGE:/public/Images/Scheffler_20230207030738AM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20230712T152609Z DESCRIPTION:"Deciphering the molecular basis of cell-surface immune signal ing"\nPlant immunity relies on both cell-surface and intracellular immune receptors. Recent studies showed that signaling triggered upon activatio n of these receptors is more connected than previously thought\, and that both types of immune receptors can induce congruent cellular immune sign aling outputs. Yet\, the exact molecular mechanisms and components involv ed in the generation and regulation of such outputs are not fully underst ood. I will present our recent efforts to gain a better understanding of the molecular basis of early immune signaling\, particularly that mediate d by cell-surface receptor kinases acting as pattern-recognition receptor s. \n\nZoom option: https://duke.zoom.us/j/95709089771 DURATION:PT1H DTSTAMP:20230712T152609Z DTSTART;TZID=America/New_York:20230714T120000 LAST-MODIFIED:20230712T152609Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Biology Seminar | Cyril Zipfel\, University of Zurich and The Sain sbury Laboratory UID:CAL-8a018cb3-8855248a-0189-4ab5b683-00006d8fdemobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=bbooher@duke.edu:Blythe Boquist X-BEDEWORK-SUBMITTEDBY:bbooher for Biology (agrp_ArtsandSciences_Biology) END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20230825T144837Z DESCRIPTION:The Department of Chemistry is excited to host Professor Abiga il Knight (University of North Carolina). \nTo learn more about the Knigh t lab's work\, please visit their research page: https://www.abigailsknig ht.com/\n\nBiomimetic hierarchical structure in synthetic macromolecules\ n\nThe remarkable functions of proteins\, from refined binding profiles t o efficient catalysis\, are currently unrivaled by synthetic macromolecul es due to complex hierarchical structure in natural systems. Inspired by this grand challenge\, the Knight group is at the interface of chemical b iology and polymer science\, developing synthetic strategies to control h ierarchical structure and high-throughput platforms to understand fundame ntal design principles underlying macromolecule conformation. These resea rch efforts are motivated by the need for innovative strategies to addres s global health and environmental challenges\, where our foundational wor k informs the de novo design and development of functional polymeric mate rials.\n\nHosted by Stephen Craig DURATION:PT1H DTSTAMP:20230827T192820Z DTSTART;TZID=America/New_York:20230905T114000 LAST-MODIFIED:20230827T192820Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Abigail Knight: "Biomimetic h ierarchical structure in synthetic macromolecules" UID:CAL-8a02906b-8a0a73d8-018a-2d2b28e2-000021d2demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che m Admin Office X-BEDEWORK-SPEAKER:Abigail Knight\, University of North Carolina X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:109 X-BEDEWORK-IMAGE-X2:746 X-BEDEWORK-IMAGE-Y2:606.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:746 X-BEDEWORK-IMAGE-CROP-HEIGHT:497.33333333333326 X-BEDEWORK-IMAGE-ALT-TEXT:Abigail Knight X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/abigail knight_20230825024837PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/abigail knight_20230825024837PM-thum b.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20230825T145306Z DESCRIPTION:The Department of Chemistry is excited to host Professor Shabn am Hematian (University of North Carolina Greensboro). \nTo learn more ab out the Hematian lab's work\, please visit their research page: https://c hem.uncg.edu/hematian/\n\nUnconventional Approaches for Mediating Redox R eactions\n\nReactions involving electron transfers are known as oxidation -reduction\, or redox\, processes\, common and vital to our daily lives. Redox reactions lie at the heart of chemical\, biological\, environmental \, and energy sciences and technologies. Here\, we show how employing unc onventional approaches and blueprints to a broad range of redox reactions taking place within homogeneous photocatalysts\, protein scaffolds\, and electrochemical systems provides an avenue for novel chemistries. Togeth er\, our studies showcase examples of redox processes proceeding under mi ld conditions\, with some being driven by light or an external bias. Spec ifically\, we investigate the photoactivation of metal-oxo bonds in coord ination compounds\, mechanism and function of a new class of copper enzym es\, and novel electrolyte materials for use in organic redox flow batter ies. Importantly\, the diversity of molecular structures\, functions\, an d mechanisms involved in these examples will highlight the versatility an d modularity of the redox reactions and their vital role in realizing a s ustainable future.\n\nHosted by Kathy Franz DURATION:PT1H DTSTAMP:20230827T192957Z DTSTART;TZID=America/New_York:20230912T114000 LAST-MODIFIED:20230827T192957Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Shabnam Hematian: "Unconventi onal Approaches for Mediating Redox Reactions" UID:CAL-8a02906b-8a0a73d8-018a-2d2f43f2-00002232demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che m Admin Office X-BEDEWORK-SPEAKER:Shabnam Hematian\, University of North Carolina Greensb oro X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:180 X-BEDEWORK-IMAGE-X2:913 X-BEDEWORK-IMAGE-Y2:788.6666666666666 X-BEDEWORK-IMAGE-CROP-WIDTH:913 X-BEDEWORK-IMAGE-CROP-HEIGHT:608.6666666666666 X-BEDEWORK-IMAGE-ALT-TEXT:Shabnam Hematian X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/Shabnam-Hematian-UNCG copy_20230825025306P M.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/Shabnam-Hematian-UNCG copy_202308250 25306PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20230825T150917Z DESCRIPTION:The Department of Chemistry is excited to host Professor Eliza beth Young (Lehigh University). \nTo learn more about the Young lab's wor k\, please visit their research page: https://wordpress.lehigh.edu/youngl ablehigh/\n\nFrom Photodynamic Therapy to Controlling Excited-State Dynam ics with Protons: Photophysics of Pd(II)biladiene and Azo dyes\n\n\nSolar light harvesting and interconversion of solar energy into either electri city or driving force for small molecule activation reactions are critica l to the production of energy and other processes that our society requir es to function. In this talk\, I will discuss two project united by photo chemistry\, each with their own application. In the first vignette\, I wi ll discuss a porphyrinoid complex\, called a Pd(II)biladiene\, This Pd(II )biladiene moiety was designed for use as a photosensitizer drug for phot odynamic therapy. Up until this point\, the excited-state dynamics of suc h biladiene complexes have been virtually unexplored. During our work on this moiety\, we discovered that while excitation into the lowest-energy absorption feature of the Pd(II)biladiene complexes produces expected pho tophysics\, interestingly\, excitation into higher-lying excited states r esulted in an additional\, unexpected lifetime. I will discuss our work t o propose the cause of this unexpected behavior. In the second vignette\, I will discuss our recent work on a ubiquitous industrial dye that is a major cause of pollution in developing countries. Azo dyes are a class of organic molecules defined by an N=N double bond connecting two aromatic moieties. They are the single most common dyes used in industrial process es\, found in everything from colorants and cosmetic additives to textile reagents\, biologic indicators\, and organic synthons. They present a si gnificant pollution problem because untreated dyes released into waterway s can be ingested and are toxic to humans and animals. Our recent studies shed light on their photophysics and how we can manipulate their photoph ysical evolution.\n\n\nHosted by David Beratan and Michael Therien DURATION:PT1H DTSTAMP:20230827T193108Z DTSTART;TZID=America/New_York:20230915T133000 LAST-MODIFIED:20230827T193108Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Elizabeth Young: "From Photod ynamic Therapy to Controlling Excited-State Dynamics with Protons: Photop hysics of Pd(II)biladiene and Azo dyes" UID:CAL-8a02906b-8a0a73d8-018a-2d3e1608-0000227ademobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che m Admin Office X-BEDEWORK-SPEAKER:Elizabeth Young\, Lehigh University X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:92 X-BEDEWORK-IMAGE-X2:900 X-BEDEWORK-IMAGE-Y2:692 X-BEDEWORK-IMAGE-CROP-WIDTH:900 X-BEDEWORK-IMAGE-CROP-HEIGHT:600 X-BEDEWORK-IMAGE-ALT-TEXT:Elizabeth Young X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/young-liz3_20230825030917PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/young-liz3_20230825030917PM-thumb.pn g END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20230825T160614Z DESCRIPTION:The Department of Chemistry is excited to host Professor Ming- Yu Ngai (Purdue). \nTo learn more about the Ngai lab's work\, please visi t their research page: https://www.ngaigroup.com/p/home.html\n\nExcited-S tate Catalysis in Organic Synthesis\n\nNgai lab aims to establish new mol ecular editing and assembling technologies for rapid synthesis and late-s tage functionalization of biorelevant molecules. Our research efforts hav e been directed to exploit visible-light-induced excited-state catalysis\ , a process that involves at least one photoexcited catalytic species\, t o address unmet challenges in organic synthesis. In this seminar\, I will cover our efforts in the development of (i) excited-state copper catalys is in carbonyl chemistry\, (ii) novel fluorinating reagents for late-stag e\, direct C-H tri- and difluoromethoxylation of aromatic compounds\, and (iii) site-selective modification of carbohydrates & beyond. Since funct ionalized carbonyl compounds\, fluorinated molecules\, and carbohydrates are ubiquitous in bioactive compounds\, our chemistry will allow convenie nt access to and studies of new functional molecules to aid the discovery of new therapeutics\, agrochemicals\, and imaging agents.\n\nHosted by Q iu Wang DURATION:PT1H DTSTAMP:20230827T193239Z DTSTART;TZID=America/New_York:20230919T114000 LAST-MODIFIED:20230827T193239Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Ming-Yu Ngai: "Excited-State Catalysis in Organic Synthesis" UID:CAL-8a02906b-8a0a73d8-018a-2d723807-00002324demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che mistry Admin Office X-BEDEWORK-SPEAKER:Ming-Yu Ngai\, Stony Brook University X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:187 X-BEDEWORK-IMAGE-X2:1067 X-BEDEWORK-IMAGE-Y2:898.3333333333334 X-BEDEWORK-IMAGE-CROP-WIDTH:1067 X-BEDEWORK-IMAGE-CROP-HEIGHT:711.3333333333334 X-BEDEWORK-IMAGE-ALT-TEXT:Ming-Yu Ngai X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/NgaiMingYu (1)_20230825040504PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/NgaiMingYu (1)_20230825040504PM-thum b.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20230825T161549Z DESCRIPTION:The Department of Chemistry is excited to host Dr. Cara Lubner (NREL). \nTo learn more about the Dr. Lubner's work\, please visit her r esearch page: https://www.nrel.gov/research/staff/cara-lubner.html\n\n'Br inging to Light the Mechanism of Flavin-Based Electron Bifurcation' \n\nA s the demand for value-added products (such as fuels\, drugs\, and small molecules) increases\, critical advances in the design of synthetic catal ysts capable of driving energetically demanding reactions will become eve n more necessary. Enzymes serve as a point of inspiration for this becaus e they can perform a variety of difficult reactions with high selectivity \, fidelity and efficiency. An intriguing target is that of flavin-based electron bifurcation (FBEB)\, a unique biological mechanism where a therm odynamically unfavorable redox reaction is driven through direct coupling with an exergonic reaction [1]. Our work focuses on investigation of the FBEB enzyme NADH-dependent ferredoxin:NADP+ oxidoreductase (Nfn)\, which modulates the concentrations of three important cellular redox pools. Co mpared with other known FBEB enzymes\, the energy landscape of Nfn is shi fted into a significantly more negative regime. As a consequence of this\ , an extremely high-energy intermediate is formed at the bifurcating flav in site which must be precisely controlled in order to efficiently perfor m bifurcation while preventing unwanted reactivity [2]. To understand thi s aspect of the mechanism\, we employed a suite of steady state and ultra fast biophysical techniques to specifically probe the properties of the e lectron bifurcating site and the initial electron transfer events [3\,4]. Our recent results have allowed us to define the thermodynamic landscape and provided insight into emerging molecular determinants that facilitat e the exquisite control over electron flow. This information is integral to understanding how energy is controlled and manipulated in complex biol ogical systems\; the insights of which will lead to design principles tha t accelerate the development of transformative energy technologies. \n\nH osted by David Beratan DURATION:PT1H DTSTAMP:20230906T203907Z DTSTART;TZID=America/New_York:20230926T114000 LAST-MODIFIED:20230906T203907Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Dr. Cara Lubner: ‘Bringing to Light the Mechanism of Flavin-Based Electron Bifurcation’ UID:CAL-8a02906b-8a0a73d8-018a-2d7afde8-000026dddemobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che m Admin Office X-BEDEWORK-SPEAKER:Cara Lubner\, NREL X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:68 X-BEDEWORK-IMAGE-X2:837 X-BEDEWORK-IMAGE-Y2:626 X-BEDEWORK-IMAGE-CROP-WIDTH:837 X-BEDEWORK-IMAGE-CROP-HEIGHT:558 X-BEDEWORK-IMAGE-ALT-TEXT:Cara Lubner X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/cara-lubner_20230906083730PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/cara-lubner_20230906083730PM-thumb.p ng END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20230825T164726Z DESCRIPTION:The Department of Chemistry is excited to host Paul Walton (Un iversity of York\, UK) for the annual Chem Connect Lecture. \n\nTo learn more about Professor Walton's work\, please visit https://www.york.ac.uk/ chemistry/staff/academic/t-z/pwalton/\n\nLytic polysaccharide monooxygena ses (LPMOs) are relatively recently discovered enzymes that catalyse the oxidation of polysaccharides\, leading to chain cleavage. LPMOs has trans formed our understanding of biomass degradation\, and-moreover-are now cr itical components in the enzymatic breakdown of biomass in the second gen eration bioethanol industry. We and others have also recently shown that LPMOs are key virulence factors in major plant diseases.\nWe have also ex amined the action of oxidizing agents on the enzyme which has been shown to enhance the activity of the enzymes on saccharidic substrates\, but al so lead to rapid inactivation of the enzyme\, presumably through protein oxidation. In this talk\, in addition to a description of the structure a nd reactivity of LPMOs\, I will show that the use of UV/vis\, CD\, XAS\, EPR\, MCD\, MS and resonance Raman spectroscopies augmented with DFT calc ulations\, reveals that one of the products of protein oxidation in an AA 9 LPMO is a long-lived ground-state singlet Cu(II)-tyrosyl species\, whic h is inactive for the oxidation of saccharidic substrates. I will also sh ow that this state evolves from an intermediate Cu(II)...tyrosyl triplet species via an open-shell singlet Cu(II)-histidyl radical-the first such species to be characterized in a protein.\n\nHosted by Kathy Franz DURATION:PT1H DTSTAMP:20230908T150144Z DTSTART;TZID=America/New_York:20231012T114000 LAST-MODIFIED:20230908T150144Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Paul Walton: "The active site s of copper oxygenases and their reactivity with H2O2" UID:CAL-8a02906b-8a0a73d8-018a-2d97eec6-00002b53demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che m Admin Office X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:183 X-BEDEWORK-IMAGE-X2:1020 X-BEDEWORK-IMAGE-Y2:863 X-BEDEWORK-IMAGE-CROP-WIDTH:1020 X-BEDEWORK-IMAGE-CROP-HEIGHT:680 X-BEDEWORK-IMAGE-ALT-TEXT:Paul Walton X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-SPEAKER:Paul Walton\, University of York\, UK X-BEDEWORK-IMAGE:/public/Images/P.Walton_20230908030144PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/P.Walton_20230908030144PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20231018T133839Z DESCRIPTION:The Department of Chemistry is excited to host Michael Inkpen (USC)\nTo learn more about the Inkpen lab's work\, please visit their res earch page: https://www.inkpenlab.org/\n\nMolecular-Scale Electronics and Moore: From Interfacial Reactivity to Band Structure Design\n\nJunctions comprising individual molecules "wired" between nanoscale electrodes app roach the limit of miniaturization for electronic circuits used in comput ation and data storage. While studies of these atomically-precise systems expose molecular structure-charge transport property relationships criti cal for the development of useful electronic components (e.g.\, wires\, s witches\, or diodes)\, the wider capabilities of such junctions\, for exa mple\, to form and break chemical bonds\, remain understudied. We are app lying glovebox-based scanning tunneling microscope-based break-junction ( STM-BJ) methods to probe single-molecule junctions formed from reactive m olecules and functional electrode metals such as Ag\, Cu\, and Co. Throug h STM-BJ conductance measurements of appropriate molecular models\, we ar e also exploring an alternative "bottom-up\," approach to electronic (ban d) structure design in extended ordered polymers such as covalent organic and metal-organic frameworks (COFs and MOFs). Together\, our work aims t o develop a deeper understanding of molecular assembly\, heterogeneous ca talysis\, and charge transport processes from the nanoscale to bulk that can be applied in the design of new devices and materials with improved p roperties.\n\nHosted by Mike Therien DURATION:PT1H DTSTAMP:20231018T133908Z DTSTART;TZID=America/New_York:20231024T114000 LAST-MODIFIED:20231018T133908Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Michael Inkpen: Molecular-Sca le Electronics and Moore: From Interfacial Reactivity to Band Structure D esign UID:CAL-8a0382b5-8b29fde3-018b-4302823f-00007f96demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che m Admin Office X-BEDEWORK-SPEAKER:Prof. Michael Inkpen X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:0 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:353.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Michael Inkpen X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/usc-chemistry-michael-inkpen2_202310180138 16PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/usc-chemistry-michael-inkpen2_202310 18013816PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20230827T191648Z DESCRIPTION:The Department of Chemistry is excited to host R. David Britt (UC Davis)\nTo learn more about the Britt lab's work\, please visit their research page: http://brittepr.ucdavis.edu/ \n\n\nEPR Studies of the Enz ymatic Synthesis of the Organometallic H-Cluster of [FeFe] Hydrogenase\n\ nThe [FeFe] hydrogenase enzymes are well suited to H2 formation\, produci ng up to 10000 H2 molecules per second\, and have therefore generated muc h interest for renewable energy applications. The H-cluster consists of a binuclear [2Fe]H subcluster which is linked via a bridging cysteine to a [4Fe-4S]H cluster. This [2Fe]H subcluster contains the organometallic e lements of the H-cluster: the two irons each have a CO and a CN- termina l ligand and are bridged by a third CO and a unique SCH2NHCH2S azadithiol ate (adt) moiety. The H+ and H2 substrates are proposed to bind to and re act at this [2Fe]H unit. In addition to the relative rarity of enzymes ca rrying out organometallic reactions\, biosynthesis of the H-cluster poise s some specific challenges. Of course\, free CO and CN- molecules are tox ic. In addition\, the bridging adt moiety is known to be unstable in solu tion. The H-cluster biosynthesis is performed by a set of three "maturase " proteins\, HydE\, HydF\, and HydG\, each containing Fe-S clusters. Two of these\, HydE and HydG\, are members of the radical SAM superfamily of enzymes\, while HydF is a GTPase. Our approach to developing a viable mec hanistic proposal for H-cluster synthesis includes chemical biology techn iques such as cell free synthesis\, isotope sensitive spectroscopy such a s electron paramagnetic resonance\, and the use of synthetic clusters tha t can serve as functional substitutes for enzyme intermediates.\n\nHosted by David Beratan DURATION:PT1H DTSTAMP:20230925T205357Z DTSTART;TZID=America/New_York:20231030T114000 LAST-MODIFIED:20230925T205357Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. R. David Britt: EPR Studies o f the Enzymatic Synthesis of the Organometallic H-Cluster of [FeFe] Hydro genase UID:CAL-8a02906b-8a0a73d8-018a-386d6907-00006a79demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che m Admin Office X-BEDEWORK-SPEAKER:R. David Britt\, University of California\, Davis X-BEDEWORK-IMAGE-X1:134 X-BEDEWORK-IMAGE-Y1:0 X-BEDEWORK-IMAGE-X2:1214 X-BEDEWORK-IMAGE-Y2:720 X-BEDEWORK-IMAGE-CROP-WIDTH:1080 X-BEDEWORK-IMAGE-CROP-HEIGHT:720 X-BEDEWORK-IMAGE-ALT-TEXT:Dave Britt X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/Dave Britt (3-8-19)_026_20230827071648PM.j pg X-BEDEWORK-THUMB-IMAGE:/public/Images/Dave Britt (3-8-19)_026_202308270716 48PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20230827T192357Z DESCRIPTION:The Department of Chemistry is excited to host Matthew R. Gold er (University of Washington)\nTo learn more about the Golder lab's work\ , please visit their research page: https://golderresearchteam.org/\n\nMa squerading Soft Materials: Anomalous Behavior in Macromolecular Design\nT he Golder Research Team utilizes fundamental principles of molecular stru cture to control synthetic polymer function. Many of society's greatest a dvancements spanning health\, sanitation\, construction\, electronics\, a nd transportation have been enabled by the invention and application of p lastics. Simultaneously\, these materials have created significant concer ns about global sustainability\, climate impact\, and environmental pollu tion. My laboratory aims to discover new materials and methods that unvei l unexpected phenomena on the macroscopic scale\; this overarching strate gy will produce next-generation designer plastics and reform how commodit y plastics are utilized. In this talk\, the team's efforts towards these common goals will be outlined in the context of recent work centered on: (1) synthetic transformations fueled by initiator and methodology develop ment\, and (2) molecular design of new soft materials.\n\nHosted by Matt Becker DURATION:PT1H DTSTAMP:20230915T155254Z DTSTART;TZID=America/New_York:20231031T114000 LAST-MODIFIED:20230915T155254Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Matthew R. Golder: "Masquerad ing Soft Materials: Anomalous Behavior in Macromolecular Design" UID:CAL-8a02906b-8a0a73d8-018a-3873f5dc-00006a7ademobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che m Admin Office X-BEDEWORK-SPEAKER:Matthew R. Golder\, University of Washington X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:79 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:432.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Matt Golder X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/matt golder2_20230915035254PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/matt golder2_20230915035254PM-thumb. png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20231218T174005Z DESCRIPTION:"Mapping and engineering gene expression with chemical and spa tial approaches"\n\nPrecise RNA expression\, tailored to specific brain r egions\, cell types\, and subcellular compartments\, is pivotal for orche strating complex brain functions. In the first part of my talk\, I will i ntroduce confocal imaging-based spatial transcriptomics platform\, STARma p\, that seamlessly combines in situ hybridization\, hydrogel tissue chem istry\, and in situ sequencing technologies. Leveraging scalable experime ntal and computational pipelines\, we have constructed a comprehensive sp atial cell atlas of the mouse brain\, revealing subregion-specific cell t ypes\, previously undiscovered tissue architectures\, and viral tropisms. The second part of my talk transits to chemical modifications on messeng er RNAs (mRNAs) and their far-reaching implications in gene expression re gulation and development of RNA therapeutics. I will elaborate on how nat urally occurring chemical modifications on mRNAs shape spatiotemporal gen e expression\, particularly in neurons undergoing activity. Furthermore\, I will discuss the messenger-oligonucleotide conjugate RNAs (mocRNAs) de sign\, showcasing how we can harness chemical modifications for engineeri ng enhanced gene delivery vectors. Looking into the future\, I will innov ate and integrate chemical and spatial profiling approaches to understand tissue health and disease in-depth.\n\nHosted by the Department of Chemi stry DURATION:PT1H DTSTAMP:20240105T205308Z DTSTART;TZID=America/New_York:20240109T114500 LAST-MODIFIED:20240105T205308Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Mapping and engineering gene expression with chemical and spatial approaches UID:CAL-8a018ccf-8b87f80e-018c-7e037992-00001a6bdemobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=c.conti@duke.edu:The Dep artment of Chemistry X-BEDEWORK-SPEAKER:Dr. Hailing Shi\, Broad Institute of MIT & Harvard X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:63 X-BEDEWORK-IMAGE-X2:800 X-BEDEWORK-IMAGE-Y2:596.3333333333334 X-BEDEWORK-IMAGE-CROP-WIDTH:800 X-BEDEWORK-IMAGE-CROP-HEIGHT:533.3333333333334 X-BEDEWORK-IMAGE-ALT-TEXT:Dr. Hailing Shi X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/Shi_20231218054005PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/Shi_20231218054005PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20231218T172647Z DESCRIPTION:"Charting the future of RNA and protein sequence-structure exp loration"\n\nRNA and protein sequences dictate their structures\, spannin g multiple length scales\, from molecular conformations to patterns of su bcellular localization. In turn\, these structures govern biological func tion. Characterizing sequence-structure relationships is critical for gai ning mechanistic understanding\, but conventional techniques can be slow and low-throughput. We have developed integrated computational and experi mental methods to overcome these limitations and applied them to resolve three-dimensional structures of a wide array of RNAs and RNA-protein comp lexes\, and to systematically reveal the protein sequence features that d rive condensate formation in cells. This work paves the way for the devel opment of transformative predictive models of sequence-structure relation ships.\n\nHosted by the Department of Chemistry DURATION:PT1H DTSTAMP:20231218T172647Z DTSTART;TZID=America/New_York:20240111T114000 LAST-MODIFIED:20231218T172647Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Charting the future of RNA and protein sequence-structure explorat ion UID:CAL-8a018ccf-8b87f80e-018c-7df74f0c-00001a6ademobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-SPEAKER:Dr. Kalli Kappel\, The Broad Institute of MIT and Harva rd X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=c.conti@duke.edu:The Dep artment of Chemistry X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:122 X-BEDEWORK-IMAGE-X2:1587 X-BEDEWORK-IMAGE-Y2:1180 X-BEDEWORK-IMAGE-CROP-WIDTH:1587 X-BEDEWORK-IMAGE-CROP-HEIGHT:1058 X-BEDEWORK-IMAGE-ALT-TEXT:Dr. Kalli Kappel X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/Kappel_20231218052648PM.png X-BEDEWORK-THUMB-IMAGE:/public/Images/Kappel_20231218052648PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20230828T002542Z DESCRIPTION:The Department of Chemistry is excited to host Brian Liau (Har vard)\nTo learn more about the Liau lab's work\, please visit their resea rch page: http://www.liaulab.org/\n\nChemical Genomics: Small Molecule Me chanism in the Era of Large-scale Genetics\n\nThe orchestrated interactio ns of protein complexes shape cell function and state. Dysregulation of t hese complexes and their interactions can underlie human disease\, and ne w therapeutic approaches to modulate them by blocking or even creating in teractions with small molecules are transforming paradigms for drug disco very. Beyond their promise as therapeutics\, small molecules are powerful tools to dissect the function and biology of protein complexes. But thei r full potential is only unlocked if we understand their mechanisms of ac tion. By combining genome editing with small molecule profiling\, we desc ribe the systematic identification of drug resistance-conferring mutation s across protein targets of interest. These mutations not only confirm on -target engagement but also act as discovery tools to uncover new biology and mechanisms through the serendipitous insights they can offer. In thi s seminar\, I will describe how the application of these chemical genomic approaches in combination with deeper mechanistic investigation have res haped our views on targeting chromatin complexes and their interactions w ith small molecules.\n\n\nHosted by Jiyong Hong DURATION:PT1H DTSTAMP:20240110T212859Z DTSTART;TZID=America/New_York:20240116T114500 LAST-MODIFIED:20240110T212859Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Brian Liau "Chemical Genomics : Small Molecule Mechanism in the Era of Large - scale Genetics" UID:CAL-8a02906b-8a0a73d8-018a-3988385b-00007166demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che m Admin Office X-BEDEWORK-SPEAKER:Brian Liau\, Harvard X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:30 X-BEDEWORK-IMAGE-X2:1638 X-BEDEWORK-IMAGE-Y2:1122 X-BEDEWORK-IMAGE-CROP-WIDTH:1638 X-BEDEWORK-IMAGE-CROP-HEIGHT:1092 X-BEDEWORK-IMAGE-ALT-TEXT:Brian Liau X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/brian_liau_square_01 (1)_20230828122542AM. jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/brian_liau_square_01 (1)_20230828122 542AM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20231218T171308Z DESCRIPTION:"From Chemistry to Circuitry: Decoding the Architecture of the Brain"\n\nThe brain is a vast network of intricately interconnected neur ons. Capturing this complex structure across multiple scales\, from nanos cale local connections to mesoscale inter-areal projections\, presents a significant challenge for imaging. Adding to this structural complexity\, the neurons within this network are not generic\; rather\, they are extr aordinarily diverse in their biochemical signatures\, which underpin thei r unique ways of processing and transmitting signals. The lack of methods to effectively integrate the molecular profiles of individual neurons wi th their structural connectivity poses another hurdle on our way to under standing brain circuitry. My presentation will delve into harnessing inno vative chemical methods and advanced microscopy to enable synapse-level c ircuit imaging across an entire mouse brain and to superimpose multiple f luorescent immunolabels onto the circuit map to interrogate the molecular identities of brain cells. I will also discuss applying this powerful to ol to advance our understanding of brain disorders that often involve alt erations in the brain's underlying circuitry but remain elusive in the di sease mechanisms.\n\nHosted by the Department of Chemistry DURATION:PT1H DTSTAMP:20231218T171308Z DTSTART;TZID=America/New_York:20240118T114500 LAST-MODIFIED:20231218T171308Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:From Chemistry to Circuitry: Decoding the Architecture of the Brai n UID:CAL-8a018ccf-8b87f80e-018c-7deacd6a-00001a69demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-SPEAKER:Dr. Xiaotang Lu\, Harvard University X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=c.conti@duke.edu:Departm ent of Chemistry X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:61 X-BEDEWORK-IMAGE-X2:600 X-BEDEWORK-IMAGE-Y2:461 X-BEDEWORK-IMAGE-CROP-WIDTH:600 X-BEDEWORK-IMAGE-CROP-HEIGHT:400 X-BEDEWORK-IMAGE-ALT-TEXT:Dr. Xiaotang Lu X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/Lu_20231218051308PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/Lu_20231218051308PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20230827T190322Z DESCRIPTION:The Department of Chemistry is excited to host Tian Qin (UT So uthwestern Medical Center) To learn more about the Qin lab's work\, pleas e visit their research page: https://labs.utsouthwestern.edu/qin-lab\n\nI nto the Next Dimension: Pharmaceutically Relevant sp3-Rich Scaffolds\n\nI nfinite chemical space provides boundless opportunities for medicinal che mists\, within which three-dimensional scaffolds with drug-like propertie s are particularly sought after. The past decade has witnessed growing in terests in novel chemical space of saturated bioisosteres such as bicyclo [1.1.1]pentanes (BCPs) and cyclopropyl trifluoromethyl group\, medicinall y relevant motifs as a three-dimensional bioisosteric replacement of arom atic moieties and tert-butyl groups. Our group develops a series of novel approaches to accessing multi-substituted BCPs\, natural products\, and other C(sp3) bioisosteres containing pharmaceutically relevant scaffolds. \n\nHosted by Steve Malcolmson DURATION:PT1H DTSTAMP:20240109T192601Z DTSTART;TZID=America/New_York:20240206T114500 LAST-MODIFIED:20240109T192601Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Tian Qin "Into the Next Dimension: Pharmaceutically Relevant sp3-Rich Scaffolds" UID:CAL-8a02906b-8a0a73d8-018a-38611b80-00006a78demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che m Admin Office X-BEDEWORK-SPEAKER:Tian Qin\, Univ. of TX Southwestern Medical Center X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:180 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:533.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.33333333333326 X-BEDEWORK-IMAGE-ALT-TEXT:Tian Qin X-BEDEWORK-IMAGE:/public/Images/TQ1_20240109072342PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/TQ1_20240109072342PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20231018T140618Z DESCRIPTION:The Department of Chemistry is excited to host Elisa Pieri (UN C). To learn more about the Pieri lab's work\, please visit their researc h page: https://www.pierilab.com/\n\nIn and out of the Intersection Seam: Insights into Photochemical Properties\n\nIn the field of photochemistry \, the role of theoretical chemistry in designing new photoactive molecul es is increasingly significant\, driven by enhanced computational capabil ities and the data science revolution. Consequently\, grasping the mechan isms governing photochemistry is critical for effective theoretical molec ular design. While nonadiabatic molecular dynamics is the technique of el ection for predicting photochemical outcomes\, its computational demands can be substantial (especially in the context of proteins and fluorescent probes)\, often necessitating prior knowledge of the photochemistry unde r investigation. Can a "simpler" exploration of the intersection seam giv e us access to photochemical properties? Addressing this challenge\, we p resent and discuss the Nonadiabatic Nanoreactor\, a novel tool that exten sively samples the intersection space between two electronic states via s eam-constrained metadynamics to pinpoint key conical intersections and li nk them to accessible photoproducts. We demonstrate the capabilities of t his tool on small organic molecules. Additionally\, we show that the ener getical accessibility of conical intersections dictates brightness in flu orescent proteins\, offering insights into the design of light-driven mol ecular systems.\n\nHosted by Jie Liu DURATION:PT1H DTSTAMP:20240130T193222Z DTSTART;TZID=America/New_York:20240213T114500 LAST-MODIFIED:20240130T193222Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Elisa Pieri "In and out of th e Intersection Seam: Insights into Photochemical Properties" UID:CAL-8a0382b5-8b29fde3-018b-431bd645-00000336demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che m Admin Office X-BEDEWORK-SPEAKER:Elisa Pieri\, UNC X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:365 X-BEDEWORK-IMAGE-X2:4000 X-BEDEWORK-IMAGE-Y2:3031.6666666666665 X-BEDEWORK-IMAGE-CROP-WIDTH:4000 X-BEDEWORK-IMAGE-CROP-HEIGHT:2666.6666666666665 X-BEDEWORK-IMAGE-ALT-TEXT:Elisa Pieri X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/Edited-Elisa-Pieri_20231018020618PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/Edited-Elisa-Pieri_20231018020618PM- thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20230828T003217Z DESCRIPTION:The Department of Chemistry is excited to host William Mustain (USC)\n\nUnderstanding how Component Chemistry and Structure Impact Anio n Exchange Membrane Electrolyzer Performance and Durabilty \n\nWater elec trolysis to produce hydrogen is gaining significant attention due to a si gnificant decrease in the cost of renewable energy sources such as solar\ , wind\, tidal etc. Among the existing water electrolysis technologies\, anion exchange membrane water electrolysis has recently emerged due to it s potential advantages over proton exchange membrane electrolysis and tra ditional alkaline electrolysis. Anion exchange membrane electrolyzers (A EMELs) can allow for the use of PGM-free electrocatalysts and low-cost co mponent materials due to its less corrosive alkaline environment while al so enabling electrochemical H2 compression. \nIn an operating AEMEL\, the anode electrode - where the oxygen evolution reaction (OER) occurs - con trols a majority of the cell's behavior. That electrode is comprised of three main components: catalyst\, ionomer/binder and porous transport lay er (PTL). Recent work has shown that under certain operating schemes tha t each of these components can dominate the anode response\, meaning that the careful design of each component is critical to ensure that the elec trolyzer can operate reliably over a wide range of operating conditions. \nThis presentation will take the audience through a series of systemati c studies that ends with a long-life and high performing AEMELs. Specific ally\, the variables to be discussed are: i) controlling the ion-exchange capacity (IEC) and cross-linker content of the ionomers\; ii) ionomer ph ysical structure\; iii) catalyst chemistry and loading\; iv) PTL density and thickness\; and v) modification of the catalyst layer with ionomer ov erlayers. The balance and sometimes compromise between performance and du rability will also be discussed. By the end of the presentation\, electro des and cells will be demonstrated that were integrated into AEMELs and a re able to show very low voltage operation on both deionized water and 0. 3 M KOH as well as stable longer-term operation. But\, most importantly\ , this project has resulted in two families of materials (polymers and PT Ls) that are now available commercially. \n\n\nTo learn more about the M ustain lab's work\, please visit their research page: https://www.mustain lab.com/\n\nHosted by Ben Wiley DURATION:PT1H DTSTAMP:20240109T192741Z DTSTART;TZID=America/New_York:20240220T114500 LAST-MODIFIED:20240109T192741Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. William Mustain UID:CAL-8a02906b-8a0a73d8-018a-398e4038-00007225demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che m Admin Office X-BEDEWORK-SPEAKER:William Mustain University of Southern California X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:0 X-BEDEWORK-IMAGE-X2:2002.5 X-BEDEWORK-IMAGE-Y2:1335 X-BEDEWORK-IMAGE-CROP-WIDTH:2002.5 X-BEDEWORK-IMAGE-CROP-HEIGHT:1335 X-BEDEWORK-IMAGE-ALT-TEXT:William Mustain X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/WMustain_pic_20230828123218AM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/WMustain_pic_20230828123218AM-thumb. png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20230828T003217Z DESCRIPTION:The Department of Chemistry is excited to host Casey Londergan (Haverford)\n\nProtein Dynamics via Vibrational Probe Groups: Untangling the Conformational Distribution\n\nProteins' natural functions are tied up in their dynamic motions\, which are often not directly reported by co nventional structural biology techniques. Vibrational spectroscopy (IR a bsorption and Raman scattering) can provide signals with intrinsic time r esolution that enables reporting on all of a protein's dynamically interc hanging structures\, and a variety of probe groups have been developed to work around the problem of spectral congestion in biomolecular vibration al spectra. These probe groups\, which are often located on artificial a mino acid side chains\, tend to have different reporting abilities\, sign al strengths\, and methods of incorporation so there is not a "one size f its all" solution to their application. In this talk I will focus on the application of two different functional group vibrations to better unders tanding dynamic\, functional structural changes\, note complementary meth ods to verify that these groups have not perturbed their host proteins\, and introduce a path forward towards using vibrational probes to determin e dynamic conformational ensembles by combining MD simulations\, vibratio nal frequency calculations\, and experimental results.\n\nTo learn more a bout Prof. Londergan's work\, please visit: https://www.haverford.edu/use rs/clonderg\n\nHosted by Kat Haas DURATION:PT1H DTSTAMP:20240221T152704Z DTSTART;TZID=America/New_York:20240227T114500 LAST-MODIFIED:20240221T152704Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Casey Londergan: "Protein Dyn amics via Vibrational Probe Groups: Untangling the Conformational Distrib ution" UID:CAL-8a0292fd-8d13410f-018d-c2fc81a0-0000707ddemobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che m Admin Office X-BEDEWORK-SPEAKER:Casey Londergan (Haverford) X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:0 X-BEDEWORK-IMAGE-X2:1450.5 X-BEDEWORK-IMAGE-Y2:967 X-BEDEWORK-IMAGE-CROP-WIDTH:1450.5 X-BEDEWORK-IMAGE-CROP-HEIGHT:967 X-BEDEWORK-IMAGE-ALT-TEXT:C. Londergan X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/Casey Londergan_20240221032704PM.png X-BEDEWORK-THUMB-IMAGE:/public/Images/Casey Londergan_20240221032704PM-thu mb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20230828T003741Z DESCRIPTION:The Department of Chemistry is excited to host Shannon Boettch er (University of California\, Berkeley)\n\nThe Chemistry and Physics of Bipolar Membranes \nwith Applications in Water\, Energy\, and Decarboniza tion\n\nProf. Shannon Boettcher\nDepartment of Chemistry and Biochemistry and the Materials Science Institute\nDirector\, Oregon Center for Electr ochemistry\n\nBipolar membranes (BPMs) are ionic analogues of semiconduct or pn junctions and consist of an anion-selective ionomer membrane lamina ted with a cation-selective ionomer membrane. BPMs generate pH gradients under bias by driving water dissociation (WD) into protons and hydroxide at the interface between the two different ionomers. In BPM water electro lysis\, this feature enables devices that drive proton reduction in local ly acidic conditions\, where electrode kinetics are fast\, and water oxid ation in locally basic conditions where efficient earth-abundant catalyst s are stable. In electrodialysis\, BPMs generate acid and base from salt water on demand for wastewater treatment/reuse\, CO2 capture from the air or ocean\, and niche applications like food/drink processing. As the pre dominant H+/OH- ion flow is out from the center of the BPM\, in electrosy nthesis BPMs mitigate deleterious cross-over of reactants and products. \ nThe key factor traditionally limiting the use of BPMs to niche applicati ons\, has been the low operating currents and high voltage losses (~0.4 V at 0.1 A/cm2). We have isolated the voltage loss in BPMs to kinetics of the water dissociation (WD) reaction\, nominally H2O → H+ + OH-. We inven ted physical electrochemical platforms to study the basic factors and mec hanisms that control the kinetics of WD\, discovering how tuned metal-oxi de nanoparticles provide surfaces with (controllable) proton-absorption s ites that catalyze WD while also focusing the interfacial electric field across the BPM junction and thus further speeding the WD rate (e.g. Scien ce 2020\, Nature Comm. 2022). Temperature-dependent measurements show the WD catalysts do not primarily lower the activation energy for WD\, but i nstead dramatically increase the number of water configurational microsta tes poised for the proton-transfer elementary steps in WD (Joule\, 2023). These discoveries enable design of new WD catalysts for BPMs that operat e with 40-times better voltage efficiency than the commercial state of th e art\, and at current-densities of up to 4 A/cm2\, opening tremendous ne w application space. DURATION:PT1H DTSTAMP:20240311T183339Z DTSTART;TZID=America/New_York:20240326T114500 LAST-MODIFIED:20240311T183339Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Shannon Boettcher "The Chemis try and Physics of Bipolar Membranes with Applications in Water\, Energy \, and Decarbonization" UID:CAL-8a02906b-8a0a73d8-018a-39933326-00007285demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che m Admin Office X-BEDEWORK-SPEAKER:Shannon Boettcher\, University of California\, Berkeley X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:368 X-BEDEWORK-IMAGE-X2:1440 X-BEDEWORK-IMAGE-Y2:1328 X-BEDEWORK-IMAGE-CROP-WIDTH:1440 X-BEDEWORK-IMAGE-CROP-HEIGHT:960 X-BEDEWORK-IMAGE-ALT-TEXT:Shannon Boettcher X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/PXL_20210514_185358555_20230828123742AM.jp g X-BEDEWORK-THUMB-IMAGE:/public/Images/PXL_20210514_185358555_2023082812374 2AM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20240326T161502Z DESCRIPTION:The Department of Chemistry is excited to host Jordan L. Meier (National Cancer Institute)\n\nAcetylation control of RNA\n\nN4-acetylcy tidine is an ancient RNA modification catalyzed by an enzyme essential fo r human life. However\, its distribution\, dynamics\, and function remain mysterious. In this seminar I will introduce my group's work developing chemical tools to investigate RNA acetylation\, how we have applied these tools to map this modification across the tree of life\, and highlight t he utility of basic research in guiding fundamental insights into the bio logy of RNA modifications as well as new therapeutic approaches.\n\nTo le arn more about Dr. Meier's work\, please visit: https://ccr.cancer.gov/st aff-directory/jordan-l-meier\n\nHosted by Emily Derbyshire and Amanda Har grove DURATION:PT1H DTSTAMP:20240326T161958Z DTSTART;TZID=America/New_York:20240409T114500 LAST-MODIFIED:20240326T161958Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Jordan L. Meier: "Acetylation contr ol of RNA" UID:CAL-8a0292fd-8d13410f-018e-7b8b3051-00005e87demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che m Admin Office X-BEDEWORK-SPEAKER:Jordan L. Meier\, National Cancer Institute X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:339 X-BEDEWORK-IMAGE-X2:2768 X-BEDEWORK-IMAGE-Y2:2184.333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:2768 X-BEDEWORK-IMAGE-CROP-HEIGHT:1845.333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Jordan L. Meier X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/JLM-photo recentered_0_20240326041809PM.jp g X-BEDEWORK-THUMB-IMAGE:/public/Images/JLM-photo recentered_0_2024032604180 9PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20231018T140046Z DESCRIPTION:The Department of Chemistry is excited to host Lu Wei (Cal Tec h). To learn more about the Wei lab's work\, please visit their research page:https://www.weilab.caltech.edu/\n\nFunctional Bond-Selective Microsc opy for Subcellular Biology: From Quantitative Imaging and Sensing to Sin gle-Molecule Analysis\n\nAdvances in optical spectroscopy and microscopy have revolutionized our understanding in live biological functions at the sub-cellular levels. In this seminar\, I will present our recent efforts in developing and applying next-generation bond-selective spectro-micros copy for retrieving functional chemical information in live cells and neu rons. I will first discuss the coupling of the stimulated Raman scatterin g (SRS) imaging\, a nonlinear Raman imaging modality\, with newly develop ed biorthogonal chemical strategies for quantitative subcellular analysis of protein aggregates in neurodegenerative diseases and for intracellula r local environmental sensing through alkyne- hydrogen-deuterium exchange (Alkyne-HDX). I will then present a new mid-infrared near-infrared doubl e-resonance imaging technique\, BonFIRE\, for bond-selective fluorescence imaging with single-molecule sensitivity. This microscopy platform shoul d allow new capabilities for wide-field super-multiplex imaging and vibra tional life-time imaging for sensing heterogeneous cellular interactions and environment. \n\nHosted by Kevin Welsher DURATION:PT1H DTSTAMP:20240415T150816Z DTSTART;TZID=America/New_York:20240423T114500 LAST-MODIFIED:20240415T150816Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Lu Wei: Functional Bond-Selective M icroscopy for Subcellular Biology: From Quantitative Imaging and Sensing to Single-Molecule Analysis UID:CAL-8a0382b5-8b29fde3-018b-4316c1dc-000002f0demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che m Admin Office X-BEDEWORK-SPEAKER:Lu Wei\, Cal Tech X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:58 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:411.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Lu Wei X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/Lu Wei photo_20240415030132PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/Lu Wei photo_20240415030132PM-thumb. png X-BEDEWORK-CS;X-BEDEWORK-PARAM-DESCRIPTION="/principals/users/agrp_Institu tes_MaterialsScienceandEngineering,/principals/users/agrp_PrattSchool_MEM S,":Duke Materials Initiative\,Mechanical Engineering and Materials Scien ce (MEMS) END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20240724T152008Z DESCRIPTION:The Department of Chemistry is excited to host Prof. Wenbin Li n (University of Chicago) on Tuesday\, September 10\, 2024 for a departme ntal seminar. \n\nTo learn more about Prof. Lin's research\, please visit : https://linlab.uchicago.edu/index.html\n\nSeminar hosted by Prof. Jie L iu DURATION:PT1H30M DTSTAMP:20240724T153403Z DTSTART;TZID=America/New_York:20240910T114000 LAST-MODIFIED:20240724T153403Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Wenbin Lin UID:CAL-8a001f8e-90a1d5f4-0190-e5540a84-00003c68demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che mistry Department X-BEDEWORK-SPEAKER:Prof. Wenbin Lin\, University of Chicago X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:203 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:556.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.33333333333326 X-BEDEWORK-IMAGE-ALT-TEXT:Professor Wenbin Lin photo X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/Lin_Wenbin_3_20240724032008PM.png X-BEDEWORK-THUMB-IMAGE:/public/Images/Lin_Wenbin_3_20240724032008PM-thumb. png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20240812T163406Z DESCRIPTION:The Department of Chemistry is pleased to host Prof. Jeetain M ittal (Texas A&M) on Tuesday\, September 17\, 2024 for a departmental sem inar. \n\nTo learn more about Prof. Mittal's research\, please visit: htt ps://jeetain.wixsite.com/mittal-lab/research\n\nSeminar hosted by Prof. P atrick Charbonneau DURATION:PT1H DTSTAMP:20240812T163406Z DTSTART;TZID=America/New_York:20240917T114000 LAST-MODIFIED:20240812T163406Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Jeetain Mittal UID:CAL-8a00048d-91324965-0191-47709839-00002aa4demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-SPEAKER:Prof. Jeetain Mittal\, Texas A&M X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che mistry Department X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:31 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:384.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Prof Jeetain Mittal from his faculty webpage X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/Mittal_20240812043406PM.png X-BEDEWORK-THUMB-IMAGE:/public/Images/Mittal_20240812043406PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20240724T152441Z DESCRIPTION:The Department of Chemistry is excited to host Prof. Ryan Hadt (California Institute of Technology) on Tuesday\, October 1\, 2024 for a departmental seminar. \n\nTo learn more about Prof. Hadt's research\, pl ease visit: https://hadtlab.caltech.edu/research-interests-techniques/\n\ nSeminar hosted by Prof. Michael Therien DURATION:PT1H30M DTSTAMP:20240724T153425Z DTSTART;TZID=America/New_York:20241001T114000 LAST-MODIFIED:20240724T153425Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Ryan Hadt UID:CAL-8a001f8e-90a1d5f4-0190-e55836ed-00003c69demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che mistry Department X-BEDEWORK-SPEAKER:Prof. Ryan Hadt\, California Institute of Technology X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:81 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:434.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Ryan Hadt Photo from Webpage X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/Hadt_Ryan2_20240724032441PM.png X-BEDEWORK-THUMB-IMAGE:/public/Images/Hadt_Ryan2_20240724032441PM-thumb.pn g END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20241002T191518Z DESCRIPTION:The Department of Chemistry is excited to host Prof. Liheng Ca i (University of Virginia) on Tuesday\, October 29\, 2024 for a departmen tal seminar. To learn more about Prof. Cai's research\, please visit: htt ps://www.softbiomatter.org/\n\nSeminar Host: Prof. Stephen Craig DURATION:PT1H DTSTAMP:20241002T191518Z DTSTART;TZID=America/New_York:20241029T114000 LAST-MODIFIED:20241002T191518Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Liheng Cai UID:CAL-8a00048d-91324965-0192-4ea8811c-000039dddemobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-SPEAKER:Liheng Cai\, University of Virginia X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Dep artment of Chemistry X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:328 X-BEDEWORK-IMAGE-X2:1302 X-BEDEWORK-IMAGE-Y2:1196 X-BEDEWORK-IMAGE-CROP-WIDTH:1302 X-BEDEWORK-IMAGE-CROP-HEIGHT:868 X-BEDEWORK-IMAGE-ALT-TEXT:Prof. Liheng Cai X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/Profile pic 1_20241002071518PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/Profile pic 1_20241002071518PM-thumb .png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20240724T153328Z DESCRIPTION:The Department of Chemistry is thrilled to host Meg Shieh (Bro wn University) on Tuesday\, November 12\, 2024 for a departmental seminar . Meg\, a NIH Pre-doctoral Fellow with Prof. Ming Xian\, will be returnin g to her alma mater to present about her current research at Brown Univer sity.\n\nTo learn more about Meg's research in the Xian lab\, please visi t: https://sites.brown.edu/mingxianlab/research/\n\nSeminar Host: Prof. Emily Derbyshire DURATION:PT1H30M DTSTAMP:20240724T153446Z DTSTART;TZID=America/New_York:20241112T114000 LAST-MODIFIED:20240724T153446Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Meg Shieh UID:CAL-8a001f8e-90a1d5f4-0190-e5604120-00003ccademobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che mistry Department X-BEDEWORK-SPEAKER:Meg Shieh\, Brown University X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:7 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:360.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Meg Shieh Photo from lab webpage X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/MegShieh_20240724033328PM.png X-BEDEWORK-THUMB-IMAGE:/public/Images/MegShieh_20240724033328PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20240724T155651Z DESCRIPTION:The Department of Chemistry is excited to host Prof. Doug Mitc hell (University of Illinois Urbana-Champaign) on Tuesday\, November 19\, 2024 for a departmental seminar. \n\nGenomics-Enabled Discovery of New M olecules & Enzymes\nAbstract: Advances in genome sequencing and bioinform atics have catalyzed a resurgence of interest in natural products. Our pr incipal focus has been on the ribosomally synthesized and post-translatio nally modified peptides (RiPPs)\, which\, despite being comprised of 50 k nown structural classes\, share a simplified biosynthetic logic and requi re a minimal genomic footprint. This talk will describe the challenges we encountered and insights we gained from large-scale RiPP genome mining. New synthetic biology approaches to accessing new molecules and discoveri ng new enzyme chemistry will be discussed\, as well as ongoing work to de fine the boundaries of nature's biosynthetic capabilities.\n\nTo learn mo re about Prof. Mitchell's research\, please visit: https://mitchell-lab.c hemistry.illinois.edu/index.html\n\nSeminar Host: Prof. Emily Derbyshire DURATION:PT1H30M DTSTAMP:20241115T185552Z DTSTART;TZID=America/New_York:20241119T114000 LAST-MODIFIED:20241115T185552Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Doug Mitchell "Genomics-Enabl ed Discovery of New Molecules & Enzymes" UID:CAL-8a001f8e-90a1d5f4-0190-e575a9bc-00003debdemobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che mistry Department X-BEDEWORK-SPEAKER:Doug Mitchell\, University of Illinois Urbana Champaign X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:16 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:369.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Doug Mitchell from research webpage X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/Mitchell_20240724035651PM.png X-BEDEWORK-THUMB-IMAGE:/public/Images/Mitchell_20240724035651PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20241002T194633Z DESCRIPTION:The Department of Chemistry is excited to host Prof. David Min h (Illinois Institute of Technology) on Tuesday\, November 26\, 2024 for a departmental seminar. To learn more about Prof. Minh's research\, pleas e visit: https://ccbatiit.github.io/\n\nSeminar Title-Computational Molec ular Pharmacology\n\nAbstract\n\nComputer modeling of structural\, thermo dynamic\, and pharmacodynamic properties can accelerate drug design by in spiring new designs and prioritizing those that are most likely to be suc cessful. My research group has recently made significant progress in bind ing pose\, affinity\, and signaling efficacy prediction. Based on a stati stical mechanics framework that I derived\, we have developed a method th at exploits multiple rigid protein conformations to quickly compute prote in-ligand binding poses and free energies. For a series of 58 ligands fro m a drug lead optimization campaign against the SARS-CoV-2 main protease\ , the method achieves a Pearson R of 0.52 and RMSE of 1.24 kcal/mol in co mparison to experiment. In what could be a significant breakthrough in GP CR signaling\, we have also developed a computational method that combine s molecular simulation and machine learning to model structural mechanism s of activation and calculate the signaling efficacy along multiple pathw ays. It computes the signaling efficacy of G protein signaling along mult iple subtypes and of arrestin recruitment for a diverse set of mu opioid receptor and cannabinoid receptor 2 ligands with a mean absolute error of less than 20%. I am excited about opportunities to further validate thes e technologies and apply them to accelerating the discovery of safe and e ffective therapeutics to improve the human condition.\n\nSeminar Host: Pr of. David Beratan DURATION:PT1H DTSTAMP:20241126T130410Z DTSTART;TZID=America/New_York:20241126T114000 LAST-MODIFIED:20241126T130410Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. David Minh UID:CAL-8a00048d-91324965-0192-4ec51de1-00003b62demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Dep artment of Chemistry X-BEDEWORK-SPEAKER:Prof. David Minh\, Illinois Institute of Technology X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:95 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:448.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:David Minh X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/david_minh_320x355_20241002074633PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/david_minh_320x355_20241002074633PM- thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20241122T182737Z DESCRIPTION:The Department of Chemistry is pleased to host Dr. Xiao Xie fo r a seminar on Thursday\, December 5.\n\nTitle: "Chemical Approaches to D ecipher Molecular Codes of Biomolecular Condensate Regulation"\n\nAbstrac t: Biomolecular condensation provides spatial and temporal control over d iverse cellular processes\, including signal transductions\, stress respo nses\, and gene regulation. In this talk\, I will first present the deve lopment of Tryptophan-selective bioconjugation chemistry (Trp-CLiC). By i ntegrating this precise chemistry with chemoproteomic methods\, we uncove red that Tryptophan-involved cation-π interactions regulate protein-media ted phase separation processes and are associated with cancer. I will the n highlight the recent advancement of a condensation-enhanced photo-cross linking strategy (DenseMAP) for direct protein interactome mapping within subcellular and subcompartmental condensates. Using DenseMAP\, we profil ed the proteome organization and dynamics of the nucleolar granular compo nent and revealed the critical role of SUMOylation in maintaining nucleol ar homeostasis. Together\, these projects demonstrate how innovations in chemical approaches can decipher molecular codes\, including interactions \, components\, and modifications\, that regulate biomolecular condensate s.\n\nHost: Chemistry Department Chemical Biology Series DURATION:PT1H DTSTAMP:20241122T182737Z DTSTART;TZID=America/New_York:20241205T114500 LAST-MODIFIED:20241122T182737Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Dr. Xiao Xie UID:CAL-8a000483-92c3adf6-0193-55212cf1-0000568ddemobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-SPEAKER:Dr. Xiao Xie\, Princeton University X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=c.conti@duke.edu:Departm ent of Chemistry X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:516 X-BEDEWORK-IMAGE-X2:2439 X-BEDEWORK-IMAGE-Y2:2142 X-BEDEWORK-IMAGE-CROP-WIDTH:2439 X-BEDEWORK-IMAGE-CROP-HEIGHT:1626 X-BEDEWORK-IMAGE-ALT-TEXT:Researcher stands in a dark colored shirt in an outdoor setting X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/Xiao Xie_20241122062737PM.JPG X-BEDEWORK-THUMB-IMAGE:/public/Images/Xiao Xie_20241122062737PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20240812T172245Z DESCRIPTION:The Department of Chemistry is pleased to host Prof. Sandeep S harma (Caltech University) on Tuesday\, January 28\, 2025\, for a departm ental seminar.\n\nTo learn more about Prof. Sharma's research\, please vi sit: https://cce.caltech.edu/people/sandeep-sharma\n\n\nSeminar hosted by Prof. Weitao Yang DURATION:PT1H DTSTAMP:20250127T165537Z DTSTART;TZID=America/New_York:20250128T114000 LAST-MODIFIED:20250127T165537Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Sandeep Sharma UID:CAL-8a00048d-91324965-0191-479d2250-00002df7demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Dep artment of Chemistry X-BEDEWORK-SPEAKER:Prof. Sandeep Sharma\, Caltech University X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:105 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:458.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Prof Sandeep Sharma from faculty webpage X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/sandeep2_20240812052245PM.png X-BEDEWORK-THUMB-IMAGE:/public/Images/sandeep2_20240812052245PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20240724T160619Z DESCRIPTION:The Department of Chemistry is excited to host Prof. Erin Stac he (Princeton University) on Tuesday\, February 4\, 2025 for a department al seminar. \n\nTo learn more about Prof. Stache's research\, please visi t: https://stache.princeton.edu/\n\nSeminar hosted by Prof. Stephen Craig DURATION:PT1H30M DTSTAMP:20240724T163051Z DTSTART;TZID=America/New_York:20250204T114000 LAST-MODIFIED:20240724T163051Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Erin Stache UID:CAL-8a001f8e-90a1d5f4-0190-e57e53aa-00003e95demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che mistry Department X-BEDEWORK-SPEAKER:Erin Stache\, Princeton University X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:27 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:380.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Prof Erin Stache from research webpage X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/Stache_20240724040619PM.png X-BEDEWORK-THUMB-IMAGE:/public/Images/Stache_20240724040619PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20240812T173811Z DESCRIPTION:The Department of Chemistry is excited to host Prof. Joaquín R odríguez-López (University of Illinois Urbana-Champaign) on Tuesday\, Feb ruary 11\, 2025 for a departmental seminar. \n\nTo learn more about Prof . Rodríguez-López's research\, please visit: https://rodriguezlopez.chemi stry.illinois.edu/research.html\n\nSeminar Host: Prof. Ivan Moreno-Hernan dez DURATION:PT1H DTSTAMP:20240812T173811Z DTSTART;TZID=America/New_York:20250211T114000 LAST-MODIFIED:20240812T173811Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Joaquín Rodríguez-López UID:CAL-8a00048d-91324965-0191-47ab41b5-00002f78demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Prof. Joaquín Rodríguez-López\, University of Illinois Urbana-Champaign) X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che mistry Department X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:47 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:400.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Prof. Joaquín Rodríguez-López from faculty webpa ge X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/Joaquin2_20240812053811PM.png X-BEDEWORK-THUMB-IMAGE:/public/Images/Joaquin2_20240812053811PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20250204T155318Z DESCRIPTION:The Department of Chemistry is excited to host Dr. Kyan D'Ange lo (University of California\, Berkeley) on Wednesday\, February 12\, 202 5 for a departmental seminar.\n\n"Simplifying Complex Molecule Synthesis and Functionalization"\n\nThe most powerful transformations in the synthe sis of complex molecules generate significant structural complexity from simple precursors. In many cases\, however\, there is no practical approa ch available to translate intuitive retrosynthetic disconnections of a gi ven target from the blackboard to the lab. This presentation will highlig ht strategies that address such challenges toward the synthesis and funct ionalization of bioactive complex molecules. These developments include a late-stage dimerization reaction applied to the total synthesis of the n atural product himastatin\, site-selective C-H borylation reactions of sa turated heterocycles\, and stereoselective glycosylation reactions of min imally protected sugars. Complex mechanistic questions concerning the fun damental reactivity and bioactivity of these molecules will be addressed throughout.\n\nTo learn more about Dr. D'Angelo's research\, please visit : https://hartwig.cchem.berkeley.edu/members/Kyan_D'Angelo\n\nSeminar Hos t: Prof. Matthew Becker DURATION:PT1H DTSTAMP:20250204T162210Z DTSTART;TZID=America/New_York:20250212T131500 LAST-MODIFIED:20250204T162210Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Kyan D'Angelo: "Simplifying Complex Molecule Synthesis and Functionalization" UID:CAL-8a000483-92c3adf6-0194-d1aa7ee6-00003196demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=c.conti@duke.edu:Departm ent of Chemistry X-BEDEWORK-SPEAKER:Dr. Kyan D'Angelo\, University of California Berkeley X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:61 X-BEDEWORK-IMAGE-X2:550 X-BEDEWORK-IMAGE-Y2:427.6666666666667 X-BEDEWORK-IMAGE-CROP-WIDTH:550 X-BEDEWORK-IMAGE-CROP-HEIGHT:366.6666666666667 X-BEDEWORK-IMAGE-ALT-TEXT:A researcher with dark hair and short beard stan ds in an outdoor setting wearing a light blue pin stripe shirt X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/KyanPhoto2_20250204042210PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/KyanPhoto2_20250204042210PM-thumb.pn g END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20250204T160031Z DESCRIPTION:The Department of Chemistry is excited to host Dr. Edwin Alfon zo (Caltech University) on Thursday\, February 13\, 2025 for a department al seminar.\n\n"Biomimetic Strategies for Lignan Synthesis and New-to-Nat ure Nitrene Transfer Reactions"\n\nClassical lignan (CL) natural products are of significant interest due to their broad spectrum of potent biolog ical activities\, leading to FDA-approved agents like etoposide and podop hyllotoxin and multiple clinical candidates. The chief source for CLs\, h owever\, remains natural sources\, constraining medicinal chemists to sem i-synthetic modifications and limiting deeper biological studies. The fir st part of the talk will describe a de novo synthetic approach inspired b y Nature's biosynthetic blueprints toward CLs. By leveraging designer pho toredox catalysts\, a highly selective\, convergent\, and modular [3+2] d ipolar cycloaddition was developed\, providing access to a key intermedia te that was advanced to all eight CLs. The developed synthetic approach p rovides efficient access to CL analogs\, enabling structure-activity rela tionship studies and library synthesis for biological testing.\n\nThe sec ond part of the talk will describe efforts in repurposing and evolving na tural heme proteins into biocatalysts capable of catalyzing new-to-nature nitrene transfer reactions. Specifically\, the development of enantiodiv ergent enzymes that allow access to L- and D-noncanonical amino acids\, c ritical in developing modern therapeutics\, will be described. The discov ery of enantiodivergent enzymes was facilitated by creating a high-throug hput experimentation workflow that connected sequence-activity-selectivit y data\, enabling the identification of highly active and selective enzym es. I will close by sharing our discovery that nitrene transferases could process abiotic boronic acids into their corresponding amines through a stereospecific 1\, 2-metallate shift mechanism. This finding opens new op portunities in biocatalysis by demonstrating that boronic acids\, commonl y used as precursors in transition-metal-catalyzed cross-coupling reactio ns\, can play a similar role with metalloenzymes.\n\nTo learn more about Dr. Alfonzo\, please visit: https://www.asbmb.org/asbmb-today/people/0508 24/mosaic-scholar-explores-enzymes\n\nSeminar hosted by Prof. Matthew Bec ker DURATION:PT1H DTSTAMP:20250204T160031Z DTSTART;TZID=America/New_York:20250213T114500 LAST-MODIFIED:20250204T160031Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Dr. Edwin Alfonzo: "Biomimetic Stra tegies for Lignan Synthesis and New-to-Nature Nitrene Transfer Reactions" UID:CAL-8a000483-92c3adf6-0194-d1b11ab9-00003240demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-SPEAKER:Dr. Edwin Alfonzo\, Caltech X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=c.conti@duke.edu:Departm ent of Chemistry X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:50 X-BEDEWORK-IMAGE-X2:800 X-BEDEWORK-IMAGE-Y2:583.3333333333334 X-BEDEWORK-IMAGE-CROP-WIDTH:800 X-BEDEWORK-IMAGE-CROP-HEIGHT:533.3333333333334 X-BEDEWORK-IMAGE-ALT-TEXT:Researcher with dark hair sits outside in a ligh t blue striped button down shirt X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/High Res Image of EA_20250204040032PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/High Res Image of EA_20250204040032P M-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20250204T160654Z DESCRIPTION:The Department of Chemistry is excited to host Dr. Samantha Ha rvey (University of Washington) on Monday\, February 17\, 2025 for a depa rtmental seminar.\n\n"Form and Function: Understanding and Controlling Pr ocesses at the Nanoscale Through Synthesis and Spectroscopy"\n\nAt the na noscale\, magnetic\, optical\, electronic\, and thermal processes can dif fer drastically from their bulk counterparts. These deviations stem from reduced crystalline domains\, large surface areas\, and quantum confineme nt\, leading to physical and chemical properties intricately dependent on size\, morphology\, and ligand identity as opposed to purely composition al structure. This remarkable tunability\, combined with their solution p rocessability\, positions colloidal nanocrystals as promising candidates for applications including photovoltaics\, catalysis\, spintronics\, and quantum-based technologies. However\, before we can input these materials into devices we need to understand and control the fundamental processes governing their formation and function.\n \nIn this talk I will share th ree short stories about how shrinking materials to the nanoscale can impa ct their properties in constructive (and destructive) ways. I'll begin by covering my most recent work on the synthesis of ferrimagnetic CuCr2Se4 nanocrystals and how their nanoscale form enables unique redox and cation exchange chemistry. The second story explores how the surfaces of CuInSe 2 nanocrystals\, and the ligands that terminate them\, can have drastic e ffects on carrier dynamics and heat dissipation. In the last story\, I wi ll transition to nanocrystal donor - molecular acceptor complexes\, which can undergo spin-polarized electron transfer. The unique electronic stru cture of the nanocrystal dictates the final spin orientation and the pote ntial for these systems to be used as qubits for quantum computing is pro bed using time-resolved optical and magnetic resonance spectroscopy. \n\n To learn more about Dr. Harvey's research\, please visit: https://depts.w ashington.edu/gmrg/people/samantha_harvey.html \n\nSeminar hosted by Prof . Matthew Becker DURATION:PT1H DTSTAMP:20250204T160654Z DTSTART;TZID=America/New_York:20250217T131500 LAST-MODIFIED:20250204T160654Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Dr. Samantha Harvey: "Form and Func tion: Understanding and Controlling Processes at the Nanoscale Through Sy nthesis and Spectroscopy" UID:CAL-8a000483-92c3adf6-0194-d1b6f217-000033c9demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Dr. Samantha Harvey\, University of Washington X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=c.conti@duke.edu:Departm ent of Chemistry X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:0 X-BEDEWORK-IMAGE-X2:4896 X-BEDEWORK-IMAGE-Y2:3264 X-BEDEWORK-IMAGE-CROP-WIDTH:4896 X-BEDEWORK-IMAGE-CROP-HEIGHT:3264 X-BEDEWORK-IMAGE-ALT-TEXT:Researcher stands in rose colored top with speck led jacket in an outdoor setting in front of numerous green leafy trees X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/Harvey_20250204040654PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/Harvey_20250204040654PM-thumb.png END:VEVENT END:VCALENDAR