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Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20231218T174005Z DESCRIPTION:"Mapping and engineering gene expression with chemical and spa tial approaches"\n\nPrecise RNA expression\, tailored to specific brain r egions\, cell types\, and subcellular compartments\, is pivotal for orche strating complex brain functions. In the first part of my talk\, I will i ntroduce confocal imaging-based spatial transcriptomics platform\, STARma p\, that seamlessly combines in situ hybridization\, hydrogel tissue chem istry\, and in situ sequencing technologies. Leveraging scalable experime ntal and computational pipelines\, we have constructed a comprehensive sp atial cell atlas of the mouse brain\, revealing subregion-specific cell t ypes\, previously undiscovered tissue architectures\, and viral tropisms. The second part of my talk transits to chemical modifications on messeng er RNAs (mRNAs) and their far-reaching implications in gene expression re gulation and development of RNA therapeutics. I will elaborate on how nat urally occurring chemical modifications on mRNAs shape spatiotemporal gen e expression\, particularly in neurons undergoing activity. Furthermore\, I will discuss the messenger-oligonucleotide conjugate RNAs (mocRNAs) de sign\, showcasing how we can harness chemical modifications for engineeri ng enhanced gene delivery vectors. Looking into the future\, I will innov ate and integrate chemical and spatial profiling approaches to understand tissue health and disease in-depth.\n\nHosted by the Department of Chemi stry DURATION:PT1H DTSTAMP:20240105T205308Z DTSTART;TZID=America/New_York:20240109T114500 LAST-MODIFIED:20240105T205308Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Mapping and engineering gene expression with chemical and spatial approaches UID:CAL-8a018ccf-8b87f80e-018c-7e037992-00001a6bdemobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=c.conti@duke.edu:The Dep artment of Chemistry X-BEDEWORK-SPEAKER:Dr. Hailing Shi\, Broad Institute of MIT & Harvard X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:63 X-BEDEWORK-IMAGE-X2:800 X-BEDEWORK-IMAGE-Y2:596.3333333333334 X-BEDEWORK-IMAGE-CROP-WIDTH:800 X-BEDEWORK-IMAGE-CROP-HEIGHT:533.3333333333334 X-BEDEWORK-IMAGE-ALT-TEXT:Dr. Hailing Shi X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/Shi_20231218054005PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/Shi_20231218054005PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20231218T172647Z DESCRIPTION:"Charting the future of RNA and protein sequence-structure exp loration"\n\nRNA and protein sequences dictate their structures\, spannin g multiple length scales\, from molecular conformations to patterns of su bcellular localization. In turn\, these structures govern biological func tion. Characterizing sequence-structure relationships is critical for gai ning mechanistic understanding\, but conventional techniques can be slow and low-throughput. We have developed integrated computational and experi mental methods to overcome these limitations and applied them to resolve three-dimensional structures of a wide array of RNAs and RNA-protein comp lexes\, and to systematically reveal the protein sequence features that d rive condensate formation in cells. This work paves the way for the devel opment of transformative predictive models of sequence-structure relation ships.\n\nHosted by the Department of Chemistry DURATION:PT1H DTSTAMP:20231218T172647Z DTSTART;TZID=America/New_York:20240111T114000 LAST-MODIFIED:20231218T172647Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Charting the future of RNA and protein sequence-structure explorat ion UID:CAL-8a018ccf-8b87f80e-018c-7df74f0c-00001a6ademobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-SPEAKER:Dr. Kalli Kappel\, The Broad Institute of MIT and Harva rd X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=c.conti@duke.edu:The Dep artment of Chemistry X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:122 X-BEDEWORK-IMAGE-X2:1587 X-BEDEWORK-IMAGE-Y2:1180 X-BEDEWORK-IMAGE-CROP-WIDTH:1587 X-BEDEWORK-IMAGE-CROP-HEIGHT:1058 X-BEDEWORK-IMAGE-ALT-TEXT:Dr. Kalli Kappel X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/Kappel_20231218052648PM.png X-BEDEWORK-THUMB-IMAGE:/public/Images/Kappel_20231218052648PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20230828T002542Z DESCRIPTION:The Department of Chemistry is excited to host Brian Liau (Har vard)\nTo learn more about the Liau lab's work\, please visit their resea rch page: http://www.liaulab.org/\n\nChemical Genomics: Small Molecule Me chanism in the Era of Large-scale Genetics\n\nThe orchestrated interactio ns of protein complexes shape cell function and state. Dysregulation of t hese complexes and their interactions can underlie human disease\, and ne w therapeutic approaches to modulate them by blocking or even creating in teractions with small molecules are transforming paradigms for drug disco very. Beyond their promise as therapeutics\, small molecules are powerful tools to dissect the function and biology of protein complexes. But thei r full potential is only unlocked if we understand their mechanisms of ac tion. By combining genome editing with small molecule profiling\, we desc ribe the systematic identification of drug resistance-conferring mutation s across protein targets of interest. These mutations not only confirm on -target engagement but also act as discovery tools to uncover new biology and mechanisms through the serendipitous insights they can offer. In thi s seminar\, I will describe how the application of these chemical genomic approaches in combination with deeper mechanistic investigation have res haped our views on targeting chromatin complexes and their interactions w ith small molecules.\n\n\nHosted by Jiyong Hong DURATION:PT1H DTSTAMP:20240110T212859Z DTSTART;TZID=America/New_York:20240116T114500 LAST-MODIFIED:20240110T212859Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Brian Liau "Chemical Genomics : Small Molecule Mechanism in the Era of Large - scale Genetics" UID:CAL-8a02906b-8a0a73d8-018a-3988385b-00007166demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che m Admin Office X-BEDEWORK-SPEAKER:Brian Liau\, Harvard X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:30 X-BEDEWORK-IMAGE-X2:1638 X-BEDEWORK-IMAGE-Y2:1122 X-BEDEWORK-IMAGE-CROP-WIDTH:1638 X-BEDEWORK-IMAGE-CROP-HEIGHT:1092 X-BEDEWORK-IMAGE-ALT-TEXT:Brian Liau X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/brian_liau_square_01 (1)_20230828122542AM. jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/brian_liau_square_01 (1)_20230828122 542AM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20231218T171308Z DESCRIPTION:"From Chemistry to Circuitry: Decoding the Architecture of the Brain"\n\nThe brain is a vast network of intricately interconnected neur ons. Capturing this complex structure across multiple scales\, from nanos cale local connections to mesoscale inter-areal projections\, presents a significant challenge for imaging. Adding to this structural complexity\, the neurons within this network are not generic\; rather\, they are extr aordinarily diverse in their biochemical signatures\, which underpin thei r unique ways of processing and transmitting signals. The lack of methods to effectively integrate the molecular profiles of individual neurons wi th their structural connectivity poses another hurdle on our way to under standing brain circuitry. My presentation will delve into harnessing inno vative chemical methods and advanced microscopy to enable synapse-level c ircuit imaging across an entire mouse brain and to superimpose multiple f luorescent immunolabels onto the circuit map to interrogate the molecular identities of brain cells. I will also discuss applying this powerful to ol to advance our understanding of brain disorders that often involve alt erations in the brain's underlying circuitry but remain elusive in the di sease mechanisms.\n\nHosted by the Department of Chemistry DURATION:PT1H DTSTAMP:20231218T171308Z DTSTART;TZID=America/New_York:20240118T114500 LAST-MODIFIED:20231218T171308Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:From Chemistry to Circuitry: Decoding the Architecture of the Brai n UID:CAL-8a018ccf-8b87f80e-018c-7deacd6a-00001a69demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-SPEAKER:Dr. Xiaotang Lu\, Harvard University X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=c.conti@duke.edu:Departm ent of Chemistry X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:61 X-BEDEWORK-IMAGE-X2:600 X-BEDEWORK-IMAGE-Y2:461 X-BEDEWORK-IMAGE-CROP-WIDTH:600 X-BEDEWORK-IMAGE-CROP-HEIGHT:400 X-BEDEWORK-IMAGE-ALT-TEXT:Dr. Xiaotang Lu X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/Lu_20231218051308PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/Lu_20231218051308PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20230827T190322Z DESCRIPTION:The Department of Chemistry is excited to host Tian Qin (UT So uthwestern Medical Center) To learn more about the Qin lab's work\, pleas e visit their research page: https://labs.utsouthwestern.edu/qin-lab\n\nI nto the Next Dimension: Pharmaceutically Relevant sp3-Rich Scaffolds\n\nI nfinite chemical space provides boundless opportunities for medicinal che mists\, within which three-dimensional scaffolds with drug-like propertie s are particularly sought after. The past decade has witnessed growing in terests in novel chemical space of saturated bioisosteres such as bicyclo [1.1.1]pentanes (BCPs) and cyclopropyl trifluoromethyl group\, medicinall y relevant motifs as a three-dimensional bioisosteric replacement of arom atic moieties and tert-butyl groups. Our group develops a series of novel approaches to accessing multi-substituted BCPs\, natural products\, and other C(sp3) bioisosteres containing pharmaceutically relevant scaffolds. \n\nHosted by Steve Malcolmson DURATION:PT1H DTSTAMP:20240109T192601Z DTSTART;TZID=America/New_York:20240206T114500 LAST-MODIFIED:20240109T192601Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Tian Qin "Into the Next Dimension: Pharmaceutically Relevant sp3-Rich Scaffolds" UID:CAL-8a02906b-8a0a73d8-018a-38611b80-00006a78demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che m Admin Office X-BEDEWORK-SPEAKER:Tian Qin\, Univ. of TX Southwestern Medical Center X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:180 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:533.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.33333333333326 X-BEDEWORK-IMAGE-ALT-TEXT:Tian Qin X-BEDEWORK-IMAGE:/public/Images/TQ1_20240109072342PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/TQ1_20240109072342PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20231018T140618Z DESCRIPTION:The Department of Chemistry is excited to host Elisa Pieri (UN C). To learn more about the Pieri lab's work\, please visit their researc h page: https://www.pierilab.com/\n\nIn and out of the Intersection Seam: Insights into Photochemical Properties\n\nIn the field of photochemistry \, the role of theoretical chemistry in designing new photoactive molecul es is increasingly significant\, driven by enhanced computational capabil ities and the data science revolution. Consequently\, grasping the mechan isms governing photochemistry is critical for effective theoretical molec ular design. While nonadiabatic molecular dynamics is the technique of el ection for predicting photochemical outcomes\, its computational demands can be substantial (especially in the context of proteins and fluorescent probes)\, often necessitating prior knowledge of the photochemistry unde r investigation. Can a "simpler" exploration of the intersection seam giv e us access to photochemical properties? Addressing this challenge\, we p resent and discuss the Nonadiabatic Nanoreactor\, a novel tool that exten sively samples the intersection space between two electronic states via s eam-constrained metadynamics to pinpoint key conical intersections and li nk them to accessible photoproducts. We demonstrate the capabilities of t his tool on small organic molecules. Additionally\, we show that the ener getical accessibility of conical intersections dictates brightness in flu orescent proteins\, offering insights into the design of light-driven mol ecular systems.\n\nHosted by Jie Liu DURATION:PT1H DTSTAMP:20240130T193222Z DTSTART;TZID=America/New_York:20240213T114500 LAST-MODIFIED:20240130T193222Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Elisa Pieri "In and out of th e Intersection Seam: Insights into Photochemical Properties" UID:CAL-8a0382b5-8b29fde3-018b-431bd645-00000336demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che m Admin Office X-BEDEWORK-SPEAKER:Elisa Pieri\, UNC X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:365 X-BEDEWORK-IMAGE-X2:4000 X-BEDEWORK-IMAGE-Y2:3031.6666666666665 X-BEDEWORK-IMAGE-CROP-WIDTH:4000 X-BEDEWORK-IMAGE-CROP-HEIGHT:2666.6666666666665 X-BEDEWORK-IMAGE-ALT-TEXT:Elisa Pieri X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/Edited-Elisa-Pieri_20231018020618PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/Edited-Elisa-Pieri_20231018020618PM- thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20230828T003217Z DESCRIPTION:The Department of Chemistry is excited to host William Mustain (USC)\n\nUnderstanding how Component Chemistry and Structure Impact Anio n Exchange Membrane Electrolyzer Performance and Durabilty \n\nWater elec trolysis to produce hydrogen is gaining significant attention due to a si gnificant decrease in the cost of renewable energy sources such as solar\ , wind\, tidal etc. Among the existing water electrolysis technologies\, anion exchange membrane water electrolysis has recently emerged due to it s potential advantages over proton exchange membrane electrolysis and tra ditional alkaline electrolysis. Anion exchange membrane electrolyzers (A EMELs) can allow for the use of PGM-free electrocatalysts and low-cost co mponent materials due to its less corrosive alkaline environment while al so enabling electrochemical H2 compression. \nIn an operating AEMEL\, the anode electrode - where the oxygen evolution reaction (OER) occurs - con trols a majority of the cell's behavior. That electrode is comprised of three main components: catalyst\, ionomer/binder and porous transport lay er (PTL). Recent work has shown that under certain operating schemes tha t each of these components can dominate the anode response\, meaning that the careful design of each component is critical to ensure that the elec trolyzer can operate reliably over a wide range of operating conditions. \nThis presentation will take the audience through a series of systemati c studies that ends with a long-life and high performing AEMELs. Specific ally\, the variables to be discussed are: i) controlling the ion-exchange capacity (IEC) and cross-linker content of the ionomers\; ii) ionomer ph ysical structure\; iii) catalyst chemistry and loading\; iv) PTL density and thickness\; and v) modification of the catalyst layer with ionomer ov erlayers. The balance and sometimes compromise between performance and du rability will also be discussed. By the end of the presentation\, electro des and cells will be demonstrated that were integrated into AEMELs and a re able to show very low voltage operation on both deionized water and 0. 3 M KOH as well as stable longer-term operation. But\, most importantly\ , this project has resulted in two families of materials (polymers and PT Ls) that are now available commercially. \n\n\nTo learn more about the M ustain lab's work\, please visit their research page: https://www.mustain lab.com/\n\nHosted by Ben Wiley DURATION:PT1H DTSTAMP:20240109T192741Z DTSTART;TZID=America/New_York:20240220T114500 LAST-MODIFIED:20240109T192741Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. William Mustain UID:CAL-8a02906b-8a0a73d8-018a-398e4038-00007225demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che m Admin Office X-BEDEWORK-SPEAKER:William Mustain University of Southern California X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:0 X-BEDEWORK-IMAGE-X2:2002.5 X-BEDEWORK-IMAGE-Y2:1335 X-BEDEWORK-IMAGE-CROP-WIDTH:2002.5 X-BEDEWORK-IMAGE-CROP-HEIGHT:1335 X-BEDEWORK-IMAGE-ALT-TEXT:William Mustain X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/WMustain_pic_20230828123218AM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/WMustain_pic_20230828123218AM-thumb. png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20230828T003217Z DESCRIPTION:The Department of Chemistry is excited to host Casey Londergan (Haverford)\n\nProtein Dynamics via Vibrational Probe Groups: Untangling the Conformational Distribution\n\nProteins' natural functions are tied up in their dynamic motions\, which are often not directly reported by co nventional structural biology techniques. Vibrational spectroscopy (IR a bsorption and Raman scattering) can provide signals with intrinsic time r esolution that enables reporting on all of a protein's dynamically interc hanging structures\, and a variety of probe groups have been developed to work around the problem of spectral congestion in biomolecular vibration al spectra. These probe groups\, which are often located on artificial a mino acid side chains\, tend to have different reporting abilities\, sign al strengths\, and methods of incorporation so there is not a "one size f its all" solution to their application. In this talk I will focus on the application of two different functional group vibrations to better unders tanding dynamic\, functional structural changes\, note complementary meth ods to verify that these groups have not perturbed their host proteins\, and introduce a path forward towards using vibrational probes to determin e dynamic conformational ensembles by combining MD simulations\, vibratio nal frequency calculations\, and experimental results.\n\nTo learn more a bout Prof. Londergan's work\, please visit: https://www.haverford.edu/use rs/clonderg\n\nHosted by Kat Haas DURATION:PT1H DTSTAMP:20240221T152704Z DTSTART;TZID=America/New_York:20240227T114500 LAST-MODIFIED:20240221T152704Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Casey Londergan: "Protein Dyn amics via Vibrational Probe Groups: Untangling the Conformational Distrib ution" UID:CAL-8a0292fd-8d13410f-018d-c2fc81a0-0000707ddemobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che m Admin Office X-BEDEWORK-SPEAKER:Casey Londergan (Haverford) X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:0 X-BEDEWORK-IMAGE-X2:1450.5 X-BEDEWORK-IMAGE-Y2:967 X-BEDEWORK-IMAGE-CROP-WIDTH:1450.5 X-BEDEWORK-IMAGE-CROP-HEIGHT:967 X-BEDEWORK-IMAGE-ALT-TEXT:C. Londergan X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/Casey Londergan_20240221032704PM.png X-BEDEWORK-THUMB-IMAGE:/public/Images/Casey Londergan_20240221032704PM-thu mb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20230828T003741Z DESCRIPTION:The Department of Chemistry is excited to host Shannon Boettch er (University of California\, Berkeley)\n\nThe Chemistry and Physics of Bipolar Membranes \nwith Applications in Water\, Energy\, and Decarboniza tion\n\nProf. Shannon Boettcher\nDepartment of Chemistry and Biochemistry and the Materials Science Institute\nDirector\, Oregon Center for Electr ochemistry\n\nBipolar membranes (BPMs) are ionic analogues of semiconduct or pn junctions and consist of an anion-selective ionomer membrane lamina ted with a cation-selective ionomer membrane. BPMs generate pH gradients under bias by driving water dissociation (WD) into protons and hydroxide at the interface between the two different ionomers. In BPM water electro lysis\, this feature enables devices that drive proton reduction in local ly acidic conditions\, where electrode kinetics are fast\, and water oxid ation in locally basic conditions where efficient earth-abundant catalyst s are stable. In electrodialysis\, BPMs generate acid and base from salt water on demand for wastewater treatment/reuse\, CO2 capture from the air or ocean\, and niche applications like food/drink processing. As the pre dominant H+/OH- ion flow is out from the center of the BPM\, in electrosy nthesis BPMs mitigate deleterious cross-over of reactants and products. \ nThe key factor traditionally limiting the use of BPMs to niche applicati ons\, has been the low operating currents and high voltage losses (~0.4 V at 0.1 A/cm2). We have isolated the voltage loss in BPMs to kinetics of the water dissociation (WD) reaction\, nominally H2O → H+ + OH-. We inven ted physical electrochemical platforms to study the basic factors and mec hanisms that control the kinetics of WD\, discovering how tuned metal-oxi de nanoparticles provide surfaces with (controllable) proton-absorption s ites that catalyze WD while also focusing the interfacial electric field across the BPM junction and thus further speeding the WD rate (e.g. Scien ce 2020\, Nature Comm. 2022). Temperature-dependent measurements show the WD catalysts do not primarily lower the activation energy for WD\, but i nstead dramatically increase the number of water configurational microsta tes poised for the proton-transfer elementary steps in WD (Joule\, 2023). These discoveries enable design of new WD catalysts for BPMs that operat e with 40-times better voltage efficiency than the commercial state of th e art\, and at current-densities of up to 4 A/cm2\, opening tremendous ne w application space. DURATION:PT1H DTSTAMP:20240311T183339Z DTSTART;TZID=America/New_York:20240326T114500 LAST-MODIFIED:20240311T183339Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Shannon Boettcher "The Chemis try and Physics of Bipolar Membranes with Applications in Water\, Energy \, and Decarbonization" UID:CAL-8a02906b-8a0a73d8-018a-39933326-00007285demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che m Admin Office X-BEDEWORK-SPEAKER:Shannon Boettcher\, University of California\, Berkeley X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:368 X-BEDEWORK-IMAGE-X2:1440 X-BEDEWORK-IMAGE-Y2:1328 X-BEDEWORK-IMAGE-CROP-WIDTH:1440 X-BEDEWORK-IMAGE-CROP-HEIGHT:960 X-BEDEWORK-IMAGE-ALT-TEXT:Shannon Boettcher X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/PXL_20210514_185358555_20230828123742AM.jp g X-BEDEWORK-THUMB-IMAGE:/public/Images/PXL_20210514_185358555_2023082812374 2AM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20240326T161502Z DESCRIPTION:The Department of Chemistry is excited to host Jordan L. Meier (National Cancer Institute)\n\nAcetylation control of RNA\n\nN4-acetylcy tidine is an ancient RNA modification catalyzed by an enzyme essential fo r human life. However\, its distribution\, dynamics\, and function remain mysterious. In this seminar I will introduce my group's work developing chemical tools to investigate RNA acetylation\, how we have applied these tools to map this modification across the tree of life\, and highlight t he utility of basic research in guiding fundamental insights into the bio logy of RNA modifications as well as new therapeutic approaches.\n\nTo le arn more about Dr. Meier's work\, please visit: https://ccr.cancer.gov/st aff-directory/jordan-l-meier\n\nHosted by Emily Derbyshire and Amanda Har grove DURATION:PT1H DTSTAMP:20240326T161958Z DTSTART;TZID=America/New_York:20240409T114500 LAST-MODIFIED:20240326T161958Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Jordan L. Meier: "Acetylation contr ol of RNA" UID:CAL-8a0292fd-8d13410f-018e-7b8b3051-00005e87demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che m Admin Office X-BEDEWORK-SPEAKER:Jordan L. Meier\, National Cancer Institute X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:339 X-BEDEWORK-IMAGE-X2:2768 X-BEDEWORK-IMAGE-Y2:2184.333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:2768 X-BEDEWORK-IMAGE-CROP-HEIGHT:1845.333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Jordan L. Meier X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/JLM-photo recentered_0_20240326041809PM.jp g X-BEDEWORK-THUMB-IMAGE:/public/Images/JLM-photo recentered_0_2024032604180 9PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20231018T140046Z DESCRIPTION:The Department of Chemistry is excited to host Lu Wei (Cal Tec h). To learn more about the Wei lab's work\, please visit their research page:https://www.weilab.caltech.edu/\n\nFunctional Bond-Selective Microsc opy for Subcellular Biology: From Quantitative Imaging and Sensing to Sin gle-Molecule Analysis\n\nAdvances in optical spectroscopy and microscopy have revolutionized our understanding in live biological functions at the sub-cellular levels. In this seminar\, I will present our recent efforts in developing and applying next-generation bond-selective spectro-micros copy for retrieving functional chemical information in live cells and neu rons. I will first discuss the coupling of the stimulated Raman scatterin g (SRS) imaging\, a nonlinear Raman imaging modality\, with newly develop ed biorthogonal chemical strategies for quantitative subcellular analysis of protein aggregates in neurodegenerative diseases and for intracellula r local environmental sensing through alkyne- hydrogen-deuterium exchange (Alkyne-HDX). I will then present a new mid-infrared near-infrared doubl e-resonance imaging technique\, BonFIRE\, for bond-selective fluorescence imaging with single-molecule sensitivity. This microscopy platform shoul d allow new capabilities for wide-field super-multiplex imaging and vibra tional life-time imaging for sensing heterogeneous cellular interactions and environment. \n\nHosted by Kevin Welsher DURATION:PT1H DTSTAMP:20240415T150816Z DTSTART;TZID=America/New_York:20240423T114500 LAST-MODIFIED:20240415T150816Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Lu Wei: Functional Bond-Selective M icroscopy for Subcellular Biology: From Quantitative Imaging and Sensing to Single-Molecule Analysis UID:CAL-8a0382b5-8b29fde3-018b-4316c1dc-000002f0demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che m Admin Office X-BEDEWORK-SPEAKER:Lu Wei\, Cal Tech X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:58 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:411.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Lu Wei X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/Lu Wei photo_20240415030132PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/Lu Wei photo_20240415030132PM-thumb. png X-BEDEWORK-CS;X-BEDEWORK-PARAM-DESCRIPTION="/principals/users/agrp_Institu tes_MaterialsScienceandEngineering,/principals/users/agrp_PrattSchool_MEM S,":Duke Materials Initiative\,Mechanical Engineering and Materials Scien ce (MEMS) END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20240724T152008Z DESCRIPTION:The Department of Chemistry is excited to host Prof. Wenbin Li n (University of Chicago) on Tuesday\, September 10\, 2024 for a departme ntal seminar. \n\nTo learn more about Prof. Lin's research\, please visit : https://linlab.uchicago.edu/index.html\n\nSeminar hosted by Prof. Jie L iu DURATION:PT1H30M DTSTAMP:20240724T153403Z DTSTART;TZID=America/New_York:20240910T114000 LAST-MODIFIED:20240724T153403Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Wenbin Lin UID:CAL-8a001f8e-90a1d5f4-0190-e5540a84-00003c68demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che mistry Department X-BEDEWORK-SPEAKER:Prof. Wenbin Lin\, University of Chicago X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:203 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:556.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.33333333333326 X-BEDEWORK-IMAGE-ALT-TEXT:Professor Wenbin Lin photo X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/Lin_Wenbin_3_20240724032008PM.png X-BEDEWORK-THUMB-IMAGE:/public/Images/Lin_Wenbin_3_20240724032008PM-thumb. png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20240812T163406Z DESCRIPTION:The Department of Chemistry is pleased to host Prof. Jeetain M ittal (Texas A&M) on Tuesday\, September 17\, 2024 for a departmental sem inar. \n\nTo learn more about Prof. Mittal's research\, please visit: htt ps://jeetain.wixsite.com/mittal-lab/research\n\nSeminar hosted by Prof. P atrick Charbonneau DURATION:PT1H DTSTAMP:20240812T163406Z DTSTART;TZID=America/New_York:20240917T114000 LAST-MODIFIED:20240812T163406Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Jeetain Mittal UID:CAL-8a00048d-91324965-0191-47709839-00002aa4demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-SPEAKER:Prof. Jeetain Mittal\, Texas A&M X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che mistry Department X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:31 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:384.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Prof Jeetain Mittal from his faculty webpage X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/Mittal_20240812043406PM.png X-BEDEWORK-THUMB-IMAGE:/public/Images/Mittal_20240812043406PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20240724T152441Z DESCRIPTION:The Department of Chemistry is excited to host Prof. Ryan Hadt (California Institute of Technology) on Tuesday\, October 1\, 2024 for a departmental seminar. \n\nTo learn more about Prof. Hadt's research\, pl ease visit: https://hadtlab.caltech.edu/research-interests-techniques/\n\ nSeminar hosted by Prof. Michael Therien DURATION:PT1H30M DTSTAMP:20240724T153425Z DTSTART;TZID=America/New_York:20241001T114000 LAST-MODIFIED:20240724T153425Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Ryan Hadt UID:CAL-8a001f8e-90a1d5f4-0190-e55836ed-00003c69demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che mistry Department X-BEDEWORK-SPEAKER:Prof. Ryan Hadt\, California Institute of Technology X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:81 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:434.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Ryan Hadt Photo from Webpage X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/Hadt_Ryan2_20240724032441PM.png X-BEDEWORK-THUMB-IMAGE:/public/Images/Hadt_Ryan2_20240724032441PM-thumb.pn g END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20241002T191518Z DESCRIPTION:The Department of Chemistry is excited to host Prof. Liheng Ca i (University of Virginia) on Tuesday\, October 29\, 2024 for a departmen tal seminar. To learn more about Prof. Cai's research\, please visit: htt ps://www.softbiomatter.org/\n\nSeminar Host: Prof. Stephen Craig DURATION:PT1H DTSTAMP:20241002T191518Z DTSTART;TZID=America/New_York:20241029T114000 LAST-MODIFIED:20241002T191518Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Liheng Cai UID:CAL-8a00048d-91324965-0192-4ea8811c-000039dddemobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-SPEAKER:Liheng Cai\, University of Virginia X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Dep artment of Chemistry X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:328 X-BEDEWORK-IMAGE-X2:1302 X-BEDEWORK-IMAGE-Y2:1196 X-BEDEWORK-IMAGE-CROP-WIDTH:1302 X-BEDEWORK-IMAGE-CROP-HEIGHT:868 X-BEDEWORK-IMAGE-ALT-TEXT:Prof. Liheng Cai X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/Profile pic 1_20241002071518PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/Profile pic 1_20241002071518PM-thumb .png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20240724T153328Z DESCRIPTION:The Department of Chemistry is thrilled to host Meg Shieh (Bro wn University) on Tuesday\, November 12\, 2024 for a departmental seminar . Meg\, a NIH Pre-doctoral Fellow with Prof. Ming Xian\, will be returnin g to her alma mater to present about her current research at Brown Univer sity.\n\nTo learn more about Meg's research in the Xian lab\, please visi t: https://sites.brown.edu/mingxianlab/research/\n\nSeminar Host: Prof. Emily Derbyshire DURATION:PT1H30M DTSTAMP:20240724T153446Z DTSTART;TZID=America/New_York:20241112T114000 LAST-MODIFIED:20240724T153446Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Meg Shieh UID:CAL-8a001f8e-90a1d5f4-0190-e5604120-00003ccademobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che mistry Department X-BEDEWORK-SPEAKER:Meg Shieh\, Brown University X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:7 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:360.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Meg Shieh Photo from lab webpage X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/MegShieh_20240724033328PM.png X-BEDEWORK-THUMB-IMAGE:/public/Images/MegShieh_20240724033328PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20240724T155651Z DESCRIPTION:The Department of Chemistry is excited to host Prof. Doug Mitc hell (University of Illinois Urbana-Champaign) on Tuesday\, November 19\, 2024 for a departmental seminar. \n\nGenomics-Enabled Discovery of New M olecules & Enzymes\nAbstract: Advances in genome sequencing and bioinform atics have catalyzed a resurgence of interest in natural products. Our pr incipal focus has been on the ribosomally synthesized and post-translatio nally modified peptides (RiPPs)\, which\, despite being comprised of 50 k nown structural classes\, share a simplified biosynthetic logic and requi re a minimal genomic footprint. This talk will describe the challenges we encountered and insights we gained from large-scale RiPP genome mining. New synthetic biology approaches to accessing new molecules and discoveri ng new enzyme chemistry will be discussed\, as well as ongoing work to de fine the boundaries of nature's biosynthetic capabilities.\n\nTo learn mo re about Prof. Mitchell's research\, please visit: https://mitchell-lab.c hemistry.illinois.edu/index.html\n\nSeminar Host: Prof. Emily Derbyshire DURATION:PT1H30M DTSTAMP:20241115T185552Z DTSTART;TZID=America/New_York:20241119T114000 LAST-MODIFIED:20241115T185552Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Doug Mitchell "Genomics-Enabl ed Discovery of New Molecules & Enzymes" UID:CAL-8a001f8e-90a1d5f4-0190-e575a9bc-00003debdemobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che mistry Department X-BEDEWORK-SPEAKER:Doug Mitchell\, University of Illinois Urbana Champaign X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:16 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:369.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Doug Mitchell from research webpage X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/Mitchell_20240724035651PM.png X-BEDEWORK-THUMB-IMAGE:/public/Images/Mitchell_20240724035651PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20241002T194633Z DESCRIPTION:The Department of Chemistry is excited to host Prof. David Min h (Illinois Institute of Technology) on Tuesday\, November 26\, 2024 for a departmental seminar. To learn more about Prof. Minh's research\, pleas e visit: https://ccbatiit.github.io/\n\nSeminar Title-Computational Molec ular Pharmacology\n\nAbstract\n\nComputer modeling of structural\, thermo dynamic\, and pharmacodynamic properties can accelerate drug design by in spiring new designs and prioritizing those that are most likely to be suc cessful. My research group has recently made significant progress in bind ing pose\, affinity\, and signaling efficacy prediction. Based on a stati stical mechanics framework that I derived\, we have developed a method th at exploits multiple rigid protein conformations to quickly compute prote in-ligand binding poses and free energies. For a series of 58 ligands fro m a drug lead optimization campaign against the SARS-CoV-2 main protease\ , the method achieves a Pearson R of 0.52 and RMSE of 1.24 kcal/mol in co mparison to experiment. In what could be a significant breakthrough in GP CR signaling\, we have also developed a computational method that combine s molecular simulation and machine learning to model structural mechanism s of activation and calculate the signaling efficacy along multiple pathw ays. It computes the signaling efficacy of G protein signaling along mult iple subtypes and of arrestin recruitment for a diverse set of mu opioid receptor and cannabinoid receptor 2 ligands with a mean absolute error of less than 20%. I am excited about opportunities to further validate thes e technologies and apply them to accelerating the discovery of safe and e ffective therapeutics to improve the human condition.\n\nSeminar Host: Pr of. David Beratan DURATION:PT1H DTSTAMP:20241126T130410Z DTSTART;TZID=America/New_York:20241126T114000 LAST-MODIFIED:20241126T130410Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. David Minh UID:CAL-8a00048d-91324965-0192-4ec51de1-00003b62demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Dep artment of Chemistry X-BEDEWORK-SPEAKER:Prof. David Minh\, Illinois Institute of Technology X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:95 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:448.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:David Minh X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/david_minh_320x355_20241002074633PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/david_minh_320x355_20241002074633PM- thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20241122T182737Z DESCRIPTION:The Department of Chemistry is pleased to host Dr. Xiao Xie fo r a seminar on Thursday\, December 5.\n\nTitle: "Chemical Approaches to D ecipher Molecular Codes of Biomolecular Condensate Regulation"\n\nAbstrac t: Biomolecular condensation provides spatial and temporal control over d iverse cellular processes\, including signal transductions\, stress respo nses\, and gene regulation. In this talk\, I will first present the deve lopment of Tryptophan-selective bioconjugation chemistry (Trp-CLiC). By i ntegrating this precise chemistry with chemoproteomic methods\, we uncove red that Tryptophan-involved cation-π interactions regulate protein-media ted phase separation processes and are associated with cancer. I will the n highlight the recent advancement of a condensation-enhanced photo-cross linking strategy (DenseMAP) for direct protein interactome mapping within subcellular and subcompartmental condensates. Using DenseMAP\, we profil ed the proteome organization and dynamics of the nucleolar granular compo nent and revealed the critical role of SUMOylation in maintaining nucleol ar homeostasis. Together\, these projects demonstrate how innovations in chemical approaches can decipher molecular codes\, including interactions \, components\, and modifications\, that regulate biomolecular condensate s.\n\nHost: Chemistry Department Chemical Biology Series DURATION:PT1H DTSTAMP:20241122T182737Z DTSTART;TZID=America/New_York:20241205T114500 LAST-MODIFIED:20241122T182737Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Dr. Xiao Xie UID:CAL-8a000483-92c3adf6-0193-55212cf1-0000568ddemobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-SPEAKER:Dr. Xiao Xie\, Princeton University X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=c.conti@duke.edu:Departm ent of Chemistry X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:516 X-BEDEWORK-IMAGE-X2:2439 X-BEDEWORK-IMAGE-Y2:2142 X-BEDEWORK-IMAGE-CROP-WIDTH:2439 X-BEDEWORK-IMAGE-CROP-HEIGHT:1626 X-BEDEWORK-IMAGE-ALT-TEXT:Researcher stands in a dark colored shirt in an outdoor setting X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/Xiao Xie_20241122062737PM.JPG X-BEDEWORK-THUMB-IMAGE:/public/Images/Xiao Xie_20241122062737PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20240812T172245Z DESCRIPTION:The Department of Chemistry is pleased to host Prof. Sandeep S harma (Caltech University) on Tuesday\, January 28\, 2025\, for a departm ental seminar.\n\nTo learn more about Prof. Sharma's research\, please vi sit: https://cce.caltech.edu/people/sandeep-sharma\n\n\nSeminar hosted by Prof. Weitao Yang DURATION:PT1H DTSTAMP:20250127T165537Z DTSTART;TZID=America/New_York:20250128T114000 LAST-MODIFIED:20250127T165537Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Sandeep Sharma UID:CAL-8a00048d-91324965-0191-479d2250-00002df7demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Dep artment of Chemistry X-BEDEWORK-SPEAKER:Prof. Sandeep Sharma\, Caltech University X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:105 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:458.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Prof Sandeep Sharma from faculty webpage X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/sandeep2_20240812052245PM.png X-BEDEWORK-THUMB-IMAGE:/public/Images/sandeep2_20240812052245PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20240724T160619Z DESCRIPTION:The Department of Chemistry is excited to host Prof. Erin Stac he (Princeton University) on Tuesday\, February 4\, 2025 for a department al seminar. \n\nTo learn more about Prof. Stache's research\, please visi t: https://stache.princeton.edu/\n\nSeminar hosted by Prof. Stephen Craig DURATION:PT1H30M DTSTAMP:20240724T163051Z DTSTART;TZID=America/New_York:20250204T114000 LAST-MODIFIED:20240724T163051Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Erin Stache UID:CAL-8a001f8e-90a1d5f4-0190-e57e53aa-00003e95demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che mistry Department X-BEDEWORK-SPEAKER:Erin Stache\, Princeton University X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:27 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:380.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Prof Erin Stache from research webpage X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/Stache_20240724040619PM.png X-BEDEWORK-THUMB-IMAGE:/public/Images/Stache_20240724040619PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20240812T173811Z DESCRIPTION:The Department of Chemistry is excited to host Prof. Joaquín R odríguez-López (University of Illinois Urbana-Champaign) on Tuesday\, Feb ruary 11\, 2025 for a departmental seminar. \n\nTo learn more about Prof . Rodríguez-López's research\, please visit: https://rodriguezlopez.chemi stry.illinois.edu/research.html\n\nSeminar Host: Prof. Ivan Moreno-Hernan dez DURATION:PT1H DTSTAMP:20240812T173811Z DTSTART;TZID=America/New_York:20250211T114000 LAST-MODIFIED:20240812T173811Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Joaquín Rodríguez-López UID:CAL-8a00048d-91324965-0191-47ab41b5-00002f78demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Prof. Joaquín Rodríguez-López\, University of Illinois Urbana-Champaign) X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che mistry Department X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:47 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:400.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Prof. Joaquín Rodríguez-López from faculty webpa ge X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/Joaquin2_20240812053811PM.png X-BEDEWORK-THUMB-IMAGE:/public/Images/Joaquin2_20240812053811PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20250204T155318Z DESCRIPTION:The Department of Chemistry is excited to host Dr. Kyan D'Ange lo (University of California\, Berkeley) on Wednesday\, February 12\, 202 5 for a departmental seminar.\n\n"Simplifying Complex Molecule Synthesis and Functionalization"\n\nThe most powerful transformations in the synthe sis of complex molecules generate significant structural complexity from simple precursors. In many cases\, however\, there is no practical approa ch available to translate intuitive retrosynthetic disconnections of a gi ven target from the blackboard to the lab. This presentation will highlig ht strategies that address such challenges toward the synthesis and funct ionalization of bioactive complex molecules. These developments include a late-stage dimerization reaction applied to the total synthesis of the n atural product himastatin\, site-selective C-H borylation reactions of sa turated heterocycles\, and stereoselective glycosylation reactions of min imally protected sugars. Complex mechanistic questions concerning the fun damental reactivity and bioactivity of these molecules will be addressed throughout.\n\nTo learn more about Dr. D'Angelo's research\, please visit : https://hartwig.cchem.berkeley.edu/members/Kyan_D'Angelo\n\nSeminar Hos t: Prof. Matthew Becker DURATION:PT1H DTSTAMP:20250204T162210Z DTSTART;TZID=America/New_York:20250212T131500 LAST-MODIFIED:20250204T162210Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Kyan D'Angelo: "Simplifying Complex Molecule Synthesis and Functionalization" UID:CAL-8a000483-92c3adf6-0194-d1aa7ee6-00003196demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=c.conti@duke.edu:Departm ent of Chemistry X-BEDEWORK-SPEAKER:Dr. Kyan D'Angelo\, University of California Berkeley X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:61 X-BEDEWORK-IMAGE-X2:550 X-BEDEWORK-IMAGE-Y2:427.6666666666667 X-BEDEWORK-IMAGE-CROP-WIDTH:550 X-BEDEWORK-IMAGE-CROP-HEIGHT:366.6666666666667 X-BEDEWORK-IMAGE-ALT-TEXT:A researcher with dark hair and short beard stan ds in an outdoor setting wearing a light blue pin stripe shirt X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/KyanPhoto2_20250204042210PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/KyanPhoto2_20250204042210PM-thumb.pn g END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20250204T160031Z DESCRIPTION:The Department of Chemistry is excited to host Dr. Edwin Alfon zo (Caltech University) on Thursday\, February 13\, 2025 for a department al seminar.\n\n"Biomimetic Strategies for Lignan Synthesis and New-to-Nat ure Nitrene Transfer Reactions"\n\nClassical lignan (CL) natural products are of significant interest due to their broad spectrum of potent biolog ical activities\, leading to FDA-approved agents like etoposide and podop hyllotoxin and multiple clinical candidates. The chief source for CLs\, h owever\, remains natural sources\, constraining medicinal chemists to sem i-synthetic modifications and limiting deeper biological studies. The fir st part of the talk will describe a de novo synthetic approach inspired b y Nature's biosynthetic blueprints toward CLs. By leveraging designer pho toredox catalysts\, a highly selective\, convergent\, and modular [3+2] d ipolar cycloaddition was developed\, providing access to a key intermedia te that was advanced to all eight CLs. The developed synthetic approach p rovides efficient access to CL analogs\, enabling structure-activity rela tionship studies and library synthesis for biological testing.\n\nThe sec ond part of the talk will describe efforts in repurposing and evolving na tural heme proteins into biocatalysts capable of catalyzing new-to-nature nitrene transfer reactions. Specifically\, the development of enantiodiv ergent enzymes that allow access to L- and D-noncanonical amino acids\, c ritical in developing modern therapeutics\, will be described. The discov ery of enantiodivergent enzymes was facilitated by creating a high-throug hput experimentation workflow that connected sequence-activity-selectivit y data\, enabling the identification of highly active and selective enzym es. I will close by sharing our discovery that nitrene transferases could process abiotic boronic acids into their corresponding amines through a stereospecific 1\, 2-metallate shift mechanism. This finding opens new op portunities in biocatalysis by demonstrating that boronic acids\, commonl y used as precursors in transition-metal-catalyzed cross-coupling reactio ns\, can play a similar role with metalloenzymes.\n\nTo learn more about Dr. Alfonzo\, please visit: https://www.asbmb.org/asbmb-today/people/0508 24/mosaic-scholar-explores-enzymes\n\nSeminar hosted by Prof. Matthew Bec ker DURATION:PT1H DTSTAMP:20250204T160031Z DTSTART;TZID=America/New_York:20250213T114500 LAST-MODIFIED:20250204T160031Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Dr. Edwin Alfonzo: "Biomimetic Stra tegies for Lignan Synthesis and New-to-Nature Nitrene Transfer Reactions" UID:CAL-8a000483-92c3adf6-0194-d1b11ab9-00003240demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-SPEAKER:Dr. Edwin Alfonzo\, Caltech X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=c.conti@duke.edu:Departm ent of Chemistry X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:50 X-BEDEWORK-IMAGE-X2:800 X-BEDEWORK-IMAGE-Y2:583.3333333333334 X-BEDEWORK-IMAGE-CROP-WIDTH:800 X-BEDEWORK-IMAGE-CROP-HEIGHT:533.3333333333334 X-BEDEWORK-IMAGE-ALT-TEXT:Researcher with dark hair sits outside in a ligh t blue striped button down shirt X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/High Res Image of EA_20250204040032PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/High Res Image of EA_20250204040032P M-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20250204T160654Z DESCRIPTION:The Department of Chemistry is excited to host Dr. Samantha Ha rvey (University of Washington) on Monday\, February 17\, 2025 for a depa rtmental seminar.\n\n"Form and Function: Understanding and Controlling Pr ocesses at the Nanoscale Through Synthesis and Spectroscopy"\n\nAt the na noscale\, magnetic\, optical\, electronic\, and thermal processes can dif fer drastically from their bulk counterparts. These deviations stem from reduced crystalline domains\, large surface areas\, and quantum confineme nt\, leading to physical and chemical properties intricately dependent on size\, morphology\, and ligand identity as opposed to purely composition al structure. This remarkable tunability\, combined with their solution p rocessability\, positions colloidal nanocrystals as promising candidates for applications including photovoltaics\, catalysis\, spintronics\, and quantum-based technologies. However\, before we can input these materials into devices we need to understand and control the fundamental processes governing their formation and function.\n \nIn this talk I will share th ree short stories about how shrinking materials to the nanoscale can impa ct their properties in constructive (and destructive) ways. I'll begin by covering my most recent work on the synthesis of ferrimagnetic CuCr2Se4 nanocrystals and how their nanoscale form enables unique redox and cation exchange chemistry. The second story explores how the surfaces of CuInSe 2 nanocrystals\, and the ligands that terminate them\, can have drastic e ffects on carrier dynamics and heat dissipation. In the last story\, I wi ll transition to nanocrystal donor - molecular acceptor complexes\, which can undergo spin-polarized electron transfer. The unique electronic stru cture of the nanocrystal dictates the final spin orientation and the pote ntial for these systems to be used as qubits for quantum computing is pro bed using time-resolved optical and magnetic resonance spectroscopy. \n\n To learn more about Dr. Harvey's research\, please visit: https://depts.w ashington.edu/gmrg/people/samantha_harvey.html \n\nSeminar hosted by Prof . Matthew Becker DURATION:PT1H DTSTAMP:20250204T160654Z DTSTART;TZID=America/New_York:20250217T131500 LAST-MODIFIED:20250204T160654Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Dr. Samantha Harvey: "Form and Func tion: Understanding and Controlling Processes at the Nanoscale Through Sy nthesis and Spectroscopy" UID:CAL-8a000483-92c3adf6-0194-d1b6f217-000033c9demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Dr. Samantha Harvey\, University of Washington X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=c.conti@duke.edu:Departm ent of Chemistry X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:0 X-BEDEWORK-IMAGE-X2:4896 X-BEDEWORK-IMAGE-Y2:3264 X-BEDEWORK-IMAGE-CROP-WIDTH:4896 X-BEDEWORK-IMAGE-CROP-HEIGHT:3264 X-BEDEWORK-IMAGE-ALT-TEXT:Researcher stands in rose colored top with speck led jacket in an outdoor setting in front of numerous green leafy trees X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/Harvey_20250204040654PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/Harvey_20250204040654PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20240805T190801Z DESCRIPTION:The Department of Chemistry is excited to host Prof. Ekaterina V. Pletneva (Dartmouth College) on Tuesday\, February 18\, 2025 for a de partmental seminar. \n\nTo learn more about Prof. Pletneva's research\, p lease visit: \nhttps://pletnevagroup.host.dartmouth.edu/ \n \nSeminar Hos t: Prof. David Beratan DURATION:PT1H30M DTSTAMP:20250207T153708Z DTSTART;TZID=America/New_York:20250218T114000 LAST-MODIFIED:20250207T153708Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Ekaterina V. Pletneva UID:CAL-8a00fee2-9105df62-0191-23f0fcc7-00001fc1demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che mistry Department X-BEDEWORK-SPEAKER:Prof. Ekaterina V. Pletneva\, Dartmouth College X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:94 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:447.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Prof. Ekaterina V. Pletneva outdoors X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/346_original2_20240805070801PM.png X-BEDEWORK-THUMB-IMAGE:/public/Images/346_original2_20240805070801PM-thumb .png END:VEVENT BEGIN:VEVENT CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20250204T161412Z DESCRIPTION:The Department of Chemistry is excited to host Dr. Kaipeng Hou (University of California San Francisco) on Thursday\, February 20\, 202 5 for a departmental seminar.\n\n"Artificial Enzymes: From Porous Materia ls to De Novo Protein Catalysts"\n\nEnzymes catalyze complex transformati ons with remarkable efficiency and selectivity. A significant challenge i n chemistry and biology has been the development of artificial systems th at can effectively mimic the functions of these enzymes. First\, I will d iscuss the synthesis of a metal-organic framework with site-isolated iron (II) centers in a coordination environment resembling the active site of taurine-α-ketoglutarate dioxygenase. This framework activates dioxygen at low temperatures to form high-spin iron(IV)=O species\, which were chara cterized using various spectroscopic methods. In the presence of dioxygen \, the framework is competent for catalytic oxygenation of cyclohexane an d the stoichiometric conversion of ethane to ethanol. To further explore enzyme-like catalysis beyond porous materials\, I will also discuss the d e novo design of protein catalysts for nonbiological reactions. By carefu lly considering reaction mechanisms and protein biophysics\, we successfu lly designed proteins incorporating synthetic porphyrins and hemes for as ymmetric catalysis\, achieving excellent enantiomeric ratios and total tu rnover numbers. These findings demonstrate that efficient de novo protein catalysts can be designed and hold great potential for a wide range of c hemical processes.\n\nSeminar hosted by Prof. Matthew Becker DURATION:PT1H DTSTAMP:20250219T231152Z DTSTART;TZID=America/New_York:20250220T120000 LAST-MODIFIED:20250219T231152Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Dr. Kaipeng Hou: "Artificial Enzyme s: From Porous Materials to De Novo Protein Catalysts" UID:CAL-8a000483-92c3adf6-0194-d1bd9f1a-000034eedemobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=c.conti@duke.edu:Departm ent of Chemistry X-BEDEWORK-SPEAKER:Dr. Kaipeng Hou\, University of California San Francisc o X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:26 X-BEDEWORK-IMAGE-X2:700 X-BEDEWORK-IMAGE-Y2:492.6666666666667 X-BEDEWORK-IMAGE-CROP-WIDTH:700 X-BEDEWORK-IMAGE-CROP-HEIGHT:466.6666666666667 X-BEDEWORK-IMAGE-ALT-TEXT:Researcher with dark hair and glasses stands in a blue suit with a maroon striped tie X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/Hou_Kaipeng3_20250204042844PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/Hou_Kaipeng3_20250204042844PM-thumb. png X-BEDEWORK-DUKE-WEBCAST:https://duke.zoom.us/j/92955824600 END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20241002T195126Z DESCRIPTION:The Department of Chemistry is excited to host Prof. Andrés Mo ntoya-Castillo (University of Colorado Boulder) on Tuesday\, February 25\ , 2025 for a departmental seminar. To learn more about Prof. Montoyo-Cast illo's research\, please visit: https://www.montoyacastillogroup.com/home \n\nSeminar Host: Prof. David Beratan DURATION:PT1H DTSTAMP:20241003T013933Z DTSTART;TZID=America/New_York:20250225T114000 LAST-MODIFIED:20241003T013933Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Andrés Montoya-Castillo UID:CAL-8a00048d-91324965-0192-4ec99707-00003bc5demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Dep artment of Chemistry X-BEDEWORK-SPEAKER:Prof. Andrés Montoya-Castillo\, University of Colorado Boulder X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:124 X-BEDEWORK-IMAGE-X2:808 X-BEDEWORK-IMAGE-Y2:662.6666666666666 X-BEDEWORK-IMAGE-CROP-WIDTH:808 X-BEDEWORK-IMAGE-CROP-HEIGHT:538.6666666666666 X-BEDEWORK-IMAGE-ALT-TEXT:Prof. Andrés Montoya-Castillo X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/Andres_20241002075127PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/Andres_20241002075127PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20240724T161401Z DESCRIPTION:The Department of Chemistry is excited to host Prof. Eric Nacs a (Penn State University) on Tuesday\, March 4\, 2025 for a departmental seminar. \n\nTo learn more about Prof. Nacsa's research\, please visit: h ttps://sites.psu.edu/nacsagroup/research/\n\nSeminar hosted by Prof. Qiu Wang DURATION:PT1H30M DTSTAMP:20240724T161401Z DTSTART;TZID=America/New_York:20250304T114000 LAST-MODIFIED:20240724T161401Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Eric Nacsa UID:CAL-8a001f8e-90a1d5f4-0190-e5855feb-00003e97demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-SPEAKER:Eric Nacsa\, Penn State University X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che mistry Department X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:55 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:408.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Prof. Eric Nacsa from research webpage X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/eric_nacsa_20240724041401PM.png X-BEDEWORK-THUMB-IMAGE:/public/Images/eric_nacsa_20240724041401PM-thumb.pn g END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20250310T160040Z DESCRIPTION:Design of β-lactam prodrugs to selectively suppress β-lactam r esistant\, pathogenic bacteria in microbial mixtures DURATION:PT1H DTSTAMP:20250310T160040Z DTSTART;TZID=America/New_York:20250312T100000 LAST-MODIFIED:20250310T160040Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Defense: Addison Duda UID:CAL-8a000483-92c3adf6-0195-80c97399-00000cc6demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-SPEAKER:Addison Duda X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:22 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:375.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:Addison Duda X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/Addison_20250310035946PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/Addison_20250310035946PM-thumb.png X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=lynn.oneill@duke.edu:Lyn n O'Neill- DGSA END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20241002T200536Z DESCRIPTION:The Department of Chemistry is excited to host Prof. Sally Hun nicutt (Virginia Commonwealth University) on Tuesday\, April 15\, 2025 fo r a departmental seminar. To learn more about Prof. Hunnicutt\, please vi sit: https://chemistry.vcu.edu/directory/sally-hunnicutt.html\n\nSeminar hosted by Prof. Kathryn Haas DURATION:PT1H DTSTAMP:20241002T200536Z DTSTART;TZID=America/New_York:20250415T114000 LAST-MODIFIED:20241002T200536Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Prof. Sally Hunnicutt UID:CAL-8a00048d-91324965-0192-4ed68c9b-00003d8fdemobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-SPEAKER:Prof. Sally Hunnicutt\, Virginia Commonwealth Universit y X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Dep artment of Chemistry X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:0 X-BEDEWORK-IMAGE-X2:800 X-BEDEWORK-IMAGE-Y2:533.3333333333334 X-BEDEWORK-IMAGE-CROP-WIDTH:800 X-BEDEWORK-IMAGE-CROP-HEIGHT:533.3333333333334 X-BEDEWORK-IMAGE-ALT-TEXT:Prof. Sally Hunnicutt X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr y) X-BEDEWORK-IMAGE:/public/Images/hunnicuttSally4x3_20241002080536PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/hunnicuttSally4x3_20241002080536PM-t humb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20250514T152638Z DESCRIPTION:Defense: Anna Truong\n\nInterrogation of Ubiquitin-Conjugating Enzyme 13 in Plasmodium Parasites DURATION:PT1H DTSTAMP:20250514T152638Z DTSTART;TZID=America/New_York:20250521T130000 LAST-MODIFIED:20250514T152638Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Defense: Anna Truong- Interrogation of Ubiquitin-Conjugating Enzym e 13 in Plasmodium Parasites UID:CAL-8a00048b-968cb292-0196-cf67a7b0-000036bddemobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che m Admin Office X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:44 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:397.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:AT X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/AT_20250514032638PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/AT_20250514032638PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20250527T142906Z DESCRIPTION:"At the Crossroads of Histidine and Copper: Structures\, Mecha nisms\, and Scope of Oxidative Reactivity on Biologically-Relevant Peptid es"\n\nHistidine is a versatile amino acid with metal-binding\, nucleophi lic\, and basic properties that endow many peptides and proteins with bio logical activity. However\, histidine itself is susceptible to oxidative modifications via post-translational modifications\, photo-oxidation\, an d metal-catalyzed oxidation. Despite multiple investigations into these d ifferent oxidation systems\, the varied attributions and differential out comes point to significant gaps in our understanding of the coordination requirements\, spectral features\, and reaction products that accompany C u-catalyzed oxidation of histidine-containing peptides. Here\, we use bio logically-relevant model peptides that have histidine-containing Cu-bindi ng sites to explore the reactions of histidine residues and Cu under redu cing and oxidizing conditions. Characterization of the Histatin-5 family of peptides via LC-MS\, MS/MS\, UV-vis\, and NMR revealed adjacent histid ine residues of the bis-His site are the main target of Cu-catalyzed oxid ation\, with predominant modifications being 2-oxo-His and His-His crossl inks that give rise to distinctive electronic absorption features between 300-400 nm. Stopped-flow experiments revealed reaction intermediates tha t indicate the ATCUN and bis-His motifs present in Histatin-5 model pepti des determine the mechanism by which the peptide will become oxidized. Re ductive or oxidative conditions initiating Cu-catalyzed oxidation also de termine the reaction rate and variety of oxidative modifications produced . The scope of Cu-catalyzed oxidation was expanded to biologically-releva nt peptides TESHHK and Amyloid Beta\, although some reactivity guidelines established by the Histatin family could not be replicated for these pep tides\, proving that the coordination requirements to enable reactivity a re more nuanced than previously thought. Finally\, progress was made towa rds the synthesis of a protected 2-oxo-His residue to be incorporated int o peptides via solid phase peptide synthesis. Together\, this work define d reactivity requirements\, mechanistic paths\, and resulting structures for histidine-rich peptides subjected to Cu-catalyzed oxidation\, and pro vides a path to study the functional ramifications of oxidative modificat ion. DURATION:PT1H DTSTAMP:20250609T175223Z DTSTART;TZID=America/New_York:20250626T130000 LAST-MODIFIED:20250609T175223Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Defense: Leah Bontreger-“At the Crossroads of Histidine and Copper : Structures\, Mechanisms\, and Scope of Oxidative Reactivity on Biologic ally-Relevant Peptides" UID:CAL-8a00048b-968cb292-0197-1225a79e-000006cbdemobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:che m admin office X-BEDEWORK-SPEAKER:Leah Bontreger X-BEDEWORK-IMAGE-X1:2 X-BEDEWORK-IMAGE-Y1:490 X-BEDEWORK-IMAGE-X2:2810 X-BEDEWORK-IMAGE-Y2:2362 X-BEDEWORK-IMAGE-CROP-WIDTH:2808 X-BEDEWORK-IMAGE-CROP-HEIGHT:1872 X-BEDEWORK-IMAGE-ALT-TEXT:LB X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/LB_20250527022906PM.jpg X-BEDEWORK-THUMB-IMAGE:/public/Images/LB_20250527022906PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None CREATED:20250521T180003Z DESCRIPTION:The Department of Chemistry is excited to Prof. Scott Miller ( Yale) on Tuesday\, September 9\, 2025\, for a departmental seminar. \n\nT o learn more about Prof. Scott Miller (Yale) research\, please visit: htt ps://millerlab.yale.edu/scott-j-miller \n\nSeminar hosted by Prof. Steve Malcomson & Prof. Qui Wang DURATION:PT1H DTSTAMP:20250818T145609Z DTSTART;TZID=America/New_York:20250909T114000 LAST-MODIFIED:20250818T145609Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Professor Scott Miller\, Yale Univ ersity UID:CAL-8a00048b-968cb292-0196-f400a10a-00005a1ademobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:0 X-BEDEWORK-IMAGE-X2:530 X-BEDEWORK-IMAGE-Y2:353.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:SM X-BEDEWORK-SUBMITTEDBY:bsg25 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/SJM_website-600x394_20250818025047PM.jpeg X-BEDEWORK-THUMB-IMAGE:/public/Images/SJM_website-600x394_20250818025047PM -thumb.png X-BEDEWORK-SPEAKER:Professor Scott Miller X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series END:VEVENT BEGIN:VEVENT CATEGORIES:Utilities CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a00048d-91324965-0191-a3b9f64b-0000517b:Grissom\, Brisa CREATED:20250910T144835Z DESCRIPTION:The Department of Chemistry is excited to host (University) on Tuesday\, DATE for a departmental seminar. \n\nTo learn more about Prof . research\, please visit: https://www.bischaklab.com/connor\n\nSeminar hosted by Prof. Ivan DURATION:PT1H DTSTAMP:20250910T144835Z DTSTART;TZID=America/New_York:20250910T090000 LAST-MODIFIED:20250910T144835Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Connor Bischak(University of Utah UID:CAL-8a00ec8b-979413b9-0199-341993be-00002380demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-SUBMITTEDBY:bsg25 for Chemistry (agrp_ArtsandSciences_Chemistry ) END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a00048d-91324965-0191-a3b9f64b-0000517b:Grissom\, Brisa CREATED:20250908T195138Z DESCRIPTION:The Department of Chemistry is excited to Professor Yang Hai University of California Santa Barbara on Tuesday\, September 16\, 2025\, for a departmental seminar. \n\nTo learn more about Professor Yang Hai University of California Santa Barbara research\, please visit: https://w ww.chem.ucsb.edu/people/yang-hai\n\nSeminar hosted by Professor Michael F itzgerald and Dr. Ken Yokoyama DURATION:PT1H DTSTAMP:20250910T142324Z DTSTART;TZID=America/New_York:20250916T114000 LAST-MODIFIED:20250910T142324Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented Professor Yang Hai University of Calif ornia Santa Barbara UID:CAL-8a00ec8b-979413b9-0199-2ae24dd9-00005af7demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-SUBMITTEDBY:bsg25 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE-X1:225 X-BEDEWORK-IMAGE-Y1:93 X-BEDEWORK-IMAGE-X2:755 X-BEDEWORK-IMAGE-Y2:446.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:530 X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333 X-BEDEWORK-IMAGE-ALT-TEXT:YN X-BEDEWORK-IMAGE:/public/Images/Admin Office Slides (10)_20250908075546PM .png X-BEDEWORK-THUMB-IMAGE:/public/Images/Admin Office Slides (10)_2025090807 5546PM-thumb.png X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-SPEAKER:Professor Yang Hai University of California Santa Barba ra X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a00048d-91324965-0191-a3b9f64b-0000517b:Grissom\, Brisa CREATED:20250820T153247Z DESCRIPTION:The Department of Chemistry is excited to host Prof. Yang Yan g (University of Wisconsin-Madison) on Tuesday\, September 23\, 2025\, fo r a departmental seminar. \n\nTo learn more about Prof. Yang Yang's resea rch\, please visit: https://chem.wisc.edu/staff/yang-yang/\n\nSeminar hos ted by Prof. Weitao Yang DURATION:PT1H DTSTAMP:20250910T142205Z DTSTART;TZID=America/New_York:20250923T114000 LAST-MODIFIED:20250910T142205Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Prof. Yang Yang (University of Wisconsin–Madiso n) UID:CAL-8a00ec8b-979413b9-0198-c81c807c-00003795demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Prof. Yang Yang X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:19 X-BEDEWORK-IMAGE-Y1:70 X-BEDEWORK-IMAGE-X2:1104 X-BEDEWORK-IMAGE-Y2:793.3333333333334 X-BEDEWORK-IMAGE-CROP-WIDTH:1085 X-BEDEWORK-IMAGE-CROP-HEIGHT:723.3333333333334 X-BEDEWORK-IMAGE-ALT-TEXT:YY X-BEDEWORK-SUBMITTEDBY:bsg25 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/Admin Office Slides (7)_20250820033205PM. png X-BEDEWORK-THUMB-IMAGE:/public/Images/Admin Office Slides (7)_20250820033 205PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a00048d-91324965-0191-a3b9f64b-0000517b:Grissom\, Brisa CREATED:20250910T140341Z DESCRIPTION:The Department of Chemistry is excited to Professor Mia Huang (Scripps Research) on Tuesday\, September 30\, 2025 for a departmental se minar. \n\nTo learn more about Professor Mia Huang (Scripps Research)rese arch\, please visit: https://www.huangresearch.com/\n\nSeminar hosted by: Prof. Jiyong Hong DURATION:PT1H DTSTAMP:20250910T142227Z DTSTART;TZID=America/New_York:20250930T114000 LAST-MODIFIED:20250910T142227Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Professor Mia Huang (Scripps Resear ch) UID:CAL-8a00ec8b-979413b9-0199-33f07b10-00001b30demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-SPEAKER:Professor Mia Huang (Scripps Research) X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:275 X-BEDEWORK-IMAGE-Y1:83 X-BEDEWORK-IMAGE-X2:1645 X-BEDEWORK-IMAGE-Y2:996.3333333333334 X-BEDEWORK-IMAGE-CROP-WIDTH:1370 X-BEDEWORK-IMAGE-CROP-HEIGHT:913.3333333333334 X-BEDEWORK-IMAGE-ALT-TEXT:MH X-BEDEWORK-SUBMITTEDBY:bsg25 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/Admin Office Slides (11)_20250910020304PM .png X-BEDEWORK-THUMB-IMAGE:/public/Images/Admin Office Slides (11)_2025091002 0304PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a00048d-91324965-0191-a3b9f64b-0000517b:Grissom\, Brisa CREATED:20250910T141104Z DESCRIPTION:The Department of Chemistry is excited to host Professor Neal Devaraj (UCSD) on Tuesday\, October 7\, 2025 for a departmental seminar. \n\nMaking\, Breaking\, and Replicating Lipid Membranes in Synthetic Cell s\n\nLipid membranes in cells are fluid structures that undergo constant synthesis\, remodeling\, fission\, and fusion. The dynamic nature of lipi d membranes enables their use as adaptive compartments\, making them indi spensable for all life on Earth. Efforts to create life-like artificial c ells will likely involve mimicking the structure and function of lipid me mbranes to recapitulate fundamental cellular processes such as growth\, t ransport\, and signal transduction. As such\, there is considerable inter est in chemistry that mimics the functional properties of membranes\, wit h the express intent of recapitulating cellular phenomena while also prov iding clues to how life might have originated. I will present recent effo rts from our lab to mimic some of the remarkable dynamic properties of li ving membranes. Leveraging the ability of small amphiphilic molecules to react with one another rapidly and selectively in aqueous environments\, our laboratory has developed methods for the abiotic synthesis of membran e-forming lipids from basic starting materials. These reactions occur spo ntaneously in water\, driving lipid self-assembly and the formation of ce ll-like membranes. While initial investigations from our laboratory prima rily yielded non-natural lipid analogs\, our recent efforts have shifted towards the development of methodologies for synthesizing membranes compo sed of lipids identical to those naturally occurring in biological system s. I will also discuss work aiming to recapitulate lipid metabolic proces ses\, but in the absence of any protein enzymes. Finally\, I will introdu ce recent efforts to develop primitive lipid replicators that can drive p rotocell reproduction.\n\n\nTo learn more about Professor Neal Devaraj (U CSD) research\, please visit: https://www.devarajgroup.com/\n\nSeminar ho sted by Prof. Qui Wang DURATION:PT1H DTSTAMP:20251006T211943Z DTSTART;TZID=America/New_York:20251007T114000 LAST-MODIFIED:20251006T211943Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Professor Neal Devaraj (UCSD): Maki ng\, Breaking\, and Replicating Lipid Membranes in Synthetic Cells UID:CAL-8a00ec8b-979413b9-0199-33f73e42-00001b92demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-SPEAKER:Professor Neal Devaraj (UCSD) X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:265 X-BEDEWORK-IMAGE-Y1:85 X-BEDEWORK-IMAGE-X2:1630 X-BEDEWORK-IMAGE-Y2:995 X-BEDEWORK-IMAGE-CROP-WIDTH:1365 X-BEDEWORK-IMAGE-CROP-HEIGHT:910 X-BEDEWORK-IMAGE-ALT-TEXT:ND X-BEDEWORK-SUBMITTEDBY:bsg25 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/Admin Office Slides (12)_20250910021104PM .png X-BEDEWORK-THUMB-IMAGE:/public/Images/Admin Office Slides (12)_2025091002 1104PM-thumb.png END:VEVENT BEGIN:VEVENT CATEGORIES:Natural Sciences CATEGORIES:Lectures/Conferences CATEGORIES:Utilities CATEGORIES:Lecture/Talk CATEGORIES:Research CATEGORIES:Main CONTACT;X-BEDEWORK-UID=8a00048d-91324965-0191-a3b9f64b-0000517b:Grissom\, Brisa CREATED:20250910T141826Z DESCRIPTION:The Department of Chemistry is excited to host Professor Sijia Dong (Northeastern University) on Tuesday\, October 28\, 2025 for a depa rtmental seminar. \n\nPhotoenzymes are emerging protein-based photocataly sts that are repurposed from natural enzymes for non-natural reactions di fficult for small-molecule catalysts. They exhibit extraordinary selectiv ity\, scalability\, and tunability\, and offer a promising new toolbox fo r solar to chemical energy conversion and chemical synthesis. However\, t he understanding and design of photoenzymes pose several challenges. Firs t\, accurate first-principles simulations of the electronic structure of macromolecules are usually computationally expensive\, especially those t hat involve strong electron correlation. In this talk\, I will discuss ou r computational strategies\, including data-driven methods and quantum co mputing\, particularly quantum annealing\, to tackle this challenge. Seco nd\, existing enzyme design strategies do not consider electronic excited states\, and photoenzyme engineering has mainly relied on directed evolu tion. I will discuss our work on physics-informed computational photoenzy me design\, where we combine physics-based simulations and data-driven me thods to demonstrate that microenvironment tuning is a promising design s trategy for photoenzymes and other macromolecular photocatalysts. \n\nTo learn more about Prof. Sijia Dong (Northeastern University) research\, pl ease visit: https://cos.northeastern.edu/people/sijia-dong/\n\nSeminar ho sted by Prof. David Beratan DURATION:PT1H DTSTAMP:20251007T173250Z DTSTART;TZID=America/New_York:20251028T114000 LAST-MODIFIED:20251007T173250Z LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa mily Science Center 2237 STATUS:CONFIRMED SUMMARY:Chemistry Seminar Presented by Professor Sijia Dong (Northeastern University)Computational Strategies for Photoenzyme Design: Physics-Based Simulations\, Data-Driven Approaches\, and Quantum Computing UID:CAL-8a00ec8b-979413b9-0199-33fdfba9-00001d71demobedework@mysite.edu X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili ties/Main X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us er/Lectures_Conferences/Lecture_Talk X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T opics/Research X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi c-user/Topics/Natural Sciences X-BEDEWORK-SPEAKER:Professor Sijia Dong (Northeastern University) X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series X-BEDEWORK-IMAGE-X1:0 X-BEDEWORK-IMAGE-Y1:95 X-BEDEWORK-IMAGE-X2:731 X-BEDEWORK-IMAGE-Y2:582.3333333333333 X-BEDEWORK-IMAGE-CROP-WIDTH:731 X-BEDEWORK-IMAGE-CROP-HEIGHT:487.33333333333326 X-BEDEWORK-IMAGE-ALT-TEXT:SD X-BEDEWORK-SUBMITTEDBY:bsg25 for Chemistry (agrp_ArtsandSciences_Chemistry ) X-BEDEWORK-IMAGE:/public/Images/1632439034693_20250910021826PM.jpeg X-BEDEWORK-THUMB-IMAGE:/public/Images/1632439034693_20250910021826PM-thumb .png END:VEVENT END:VCALENDAR