BEGIN:VCALENDAR
PRODID:BedeWork V3.5
VERSION:2.0
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:America/New_York
X-LIC-LOCATION:America/New_York
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20070311T020000
RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=2SU
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20071104T020000
RRULE:FREQ=YEARLY;BYMONTH=11;BYDAY=1SU
END:STANDARD
BEGIN:STANDARD
TZOFFSETFROM:-045602
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:18831118T120358
RDATE:18831118T120358
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:19180331T020000
RDATE:19180331T020000
RDATE:19190330T020000
RDATE:19200328T020000
RDATE:19210424T020000
RDATE:19220430T020000
RDATE:19230429T020000
RDATE:19240427T020000
RDATE:19250426T020000
RDATE:19260425T020000
RDATE:19270424T020000
RDATE:19280429T020000
RDATE:19290428T020000
RDATE:19300427T020000
RDATE:19310426T020000
RDATE:19320424T020000
RDATE:19330430T020000
RDATE:19340429T020000
RDATE:19350428T020000
RDATE:19360426T020000
RDATE:19370425T020000
RDATE:19380424T020000
RDATE:19390430T020000
RDATE:19400428T020000
RDATE:19410427T020000
RDATE:19460428T020000
RDATE:19470427T020000
RDATE:19480425T020000
RDATE:19490424T020000
RDATE:19500430T020000
RDATE:19510429T020000
RDATE:19520427T020000
RDATE:19530426T020000
RDATE:19540425T020000
RDATE:19550424T020000
RDATE:19560429T020000
RDATE:19570428T020000
RDATE:19580427T020000
RDATE:19590426T020000
RDATE:19600424T020000
RDATE:19610430T020000
RDATE:19620429T020000
RDATE:19630428T020000
RDATE:19640426T020000
RDATE:19650425T020000
RDATE:19660424T020000
RDATE:19670430T020000
RDATE:19680428T020000
RDATE:19690427T020000
RDATE:19700426T020000
RDATE:19710425T020000
RDATE:19720430T020000
RDATE:19730429T020000
RDATE:19740106T020000
RDATE:19750223T020000
RDATE:19760425T020000
RDATE:19770424T020000
RDATE:19780430T020000
RDATE:19790429T020000
RDATE:19800427T020000
RDATE:19810426T020000
RDATE:19820425T020000
RDATE:19830424T020000
RDATE:19840429T020000
RDATE:19850428T020000
RDATE:19860427T020000
RDATE:19870405T020000
RDATE:19880403T020000
RDATE:19890402T020000
RDATE:19900401T020000
RDATE:19910407T020000
RDATE:19920405T020000
RDATE:19930404T020000
RDATE:19940403T020000
RDATE:19950402T020000
RDATE:19960407T020000
RDATE:19970406T020000
RDATE:19980405T020000
RDATE:19990404T020000
RDATE:20000402T020000
RDATE:20010401T020000
RDATE:20020407T020000
RDATE:20030406T020000
RDATE:20040404T020000
RDATE:20050403T020000
RDATE:20060402T020000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:19181027T020000
RDATE:19181027T020000
RDATE:19191026T020000
RDATE:19201031T020000
RDATE:19210925T020000
RDATE:19220924T020000
RDATE:19230930T020000
RDATE:19240928T020000
RDATE:19250927T020000
RDATE:19260926T020000
RDATE:19270925T020000
RDATE:19280930T020000
RDATE:19290929T020000
RDATE:19300928T020000
RDATE:19310927T020000
RDATE:19320925T020000
RDATE:19330924T020000
RDATE:19340930T020000
RDATE:19350929T020000
RDATE:19360927T020000
RDATE:19370926T020000
RDATE:19380925T020000
RDATE:19390924T020000
RDATE:19400929T020000
RDATE:19410928T020000
RDATE:19450930T020000
RDATE:19460929T020000
RDATE:19470928T020000
RDATE:19480926T020000
RDATE:19490925T020000
RDATE:19500924T020000
RDATE:19510930T020000
RDATE:19520928T020000
RDATE:19530927T020000
RDATE:19540926T020000
RDATE:19551030T020000
RDATE:19561028T020000
RDATE:19571027T020000
RDATE:19581026T020000
RDATE:19591025T020000
RDATE:19601030T020000
RDATE:19611029T020000
RDATE:19621028T020000
RDATE:19631027T020000
RDATE:19641025T020000
RDATE:19651031T020000
RDATE:19661030T020000
RDATE:19671029T020000
RDATE:19681027T020000
RDATE:19691026T020000
RDATE:19701025T020000
RDATE:19711031T020000
RDATE:19721029T020000
RDATE:19731028T020000
RDATE:19741027T020000
RDATE:19751026T020000
RDATE:19761031T020000
RDATE:19771030T020000
RDATE:19781029T020000
RDATE:19791028T020000
RDATE:19801026T020000
RDATE:19811025T020000
RDATE:19821031T020000
RDATE:19831030T020000
RDATE:19841028T020000
RDATE:19851027T020000
RDATE:19861026T020000
RDATE:19871025T020000
RDATE:19881030T020000
RDATE:19891029T020000
RDATE:19901028T020000
RDATE:19911027T020000
RDATE:19921025T020000
RDATE:19931031T020000
RDATE:19941030T020000
RDATE:19951029T020000
RDATE:19961027T020000
RDATE:19971026T020000
RDATE:19981025T020000
RDATE:19991031T020000
RDATE:20001029T020000
RDATE:20011028T020000
RDATE:20021027T020000
RDATE:20031026T020000
RDATE:20041031T020000
RDATE:20051030T020000
RDATE:20061029T020000
END:STANDARD
BEGIN:STANDARD
TZOFFSETFROM:-0500
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:19200101T000000
RDATE:19200101T000000
RDATE:19420101T000000
RDATE:19460101T000000
RDATE:19670101T000000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EWT
DTSTART:19420209T020000
RDATE:19420209T020000
END:DAYLIGHT
BEGIN:DAYLIGHT
TZOFFSETFROM:-0400
TZOFFSETTO:-0400
TZNAME:EPT
DTSTART:19450814T190000
RDATE:19450814T190000
END:DAYLIGHT
END:VTIMEZONE
BEGIN:VEVENT

CATEGORIES:Medicine
CATEGORIES:Natural Sciences
CATEGORIES:Lectures/Conferences
CATEGORIES:Utilities
CATEGORIES:Health/Wellness
CATEGORIES:Lecture/Talk
CATEGORIES:Panel/Seminar/Colloquium
CATEGORIES:Research
CATEGORIES:Main
CONTACT;X-BEDEWORK-UID=8a028ad1-899cba17-0189-d5fdf440-0000488b:Straehle\,
  Jessica
CREATED:20231228T191206Z
DESCRIPTION:Polyunsaturated fatty acids undergo enzymatic oxidation and ge
 nerate diverse lipid mediators that play crucial roles in regulating immu
 ne cell behavior\, blood clotting\, blood vessel permeability\, and tissu
 e repair. This seminar will discuss the significance of polyunsaturated f
 atty acid metabolism in relation to the cardiopulmonary effects of air po
 llution within real-world populations.\n\nDr. Yan Lin is a postdoctoral a
 ssociate at Duke Global Health Institute. He received his Ph.D. degree fr
 om UCLA in 2019. Dr. Lin's research interests revolve around investigatin
 g the health effects of air pollution and climate change. His research wa
 s built upon efforts to (1) discover novel exposure biomarkers that are m
 ore sensitive and specific to emerging pollution sources (e.g.\, wildfire
 )\, and (2) identify key signaling pathways that mediate the health effec
 ts of air pollution and/or climate change. These dual efforts contribute 
 synergistically\, ultimately facilitating the identification of environme
 ntal etiological factors of cardiopulmonary disease and adverse birth out
 comes.\n\nTHIS IS A HYBRID SEMINAR WITH IN-PERSON & REMOTE ATTENDANCE OPT
 IONS.\nThis seminar will be held in Field Auditorium (room 1112)\, Graing
 er Hall.\nVisit the seminar website for a livestream link to tune in virt
 ually.\nBoth attendance options (in person and virtual) are free and open
  to all.
DURATION:PT1H15M
DTSTAMP:20231228T191206Z
DTSTART;TZID=America/New_York:20240118T120000
LAST-MODIFIED:20231228T191206Z
LOCATION;X-BEDEWORK-UID=8a0870ee-47c7da7d-0147-edb93ef0-00004d1e:Grainger 
 Hall 1112
STATUS:CONFIRMED
SUMMARY:Polyunsaturated Fatty Acid-Derived Lipid Mediators: A Link Between
  Air Pollution and Cardiopulmonary Disease Development?
UID:CAL-8a018ccf-8b87f80e-018c-b1d750fd-00001c63demobedework@mysite.edu
URL:https://sites.nicholas.duke.edu/envhealth/seminars-symposia/spring-202
 4-seminar-series/january-18-2024-polyunsaturated-fatty-acid-derived-lipid
 -mediators-a-link-between-air-pollution-and-cardiopulmonary-disease-devel
 opment/
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili
 ties/Main
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us
 er/Lectures_Conferences/Lecture_Talk
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Panel_Seminar_Colloquium:/us
 er/public-user/Lectures_Conferences/Panel_Seminar_Colloquium
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T
 opics/Research
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi
 c-user/Topics/Natural Sciences
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Medicine:/user/public-user/T
 opics/Medicine
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Health_Wellness:/user/public
 -user/Topics/Health_Wellness
X-BEDEWORK-CS;X-BEDEWORK-PARAM-DESCRIPTION="/principals/users/agrp_NSOE,":
 Nicholas School of the Environment
X-BEDEWORK-SPEAKER:Yan Lin\, PhD\, Duke University
X-BEDEWORK-DUKE-SERIES:Integrated Toxicology & Environmental Health Semina
 r Series
X-BEDEWORK-IMAGE-X1:0
X-BEDEWORK-IMAGE-Y2:353
X-BEDEWORK-IMAGE-ALT-TEXT:Seminar speaker\, Dr. Yan Lin
X-BEDEWORK-IMAGE-Y1:0
X-BEDEWORK-IMAGE-X2:529.5
X-BEDEWORK-IMAGE-CROP-WIDTH:529.5
X-BEDEWORK-IMAGE-CROP-HEIGHT:353
X-BEDEWORK-SUBMITTEDBY:jls265 for Integrated Toxicology &amp\; Environment
 al Health (ITEHP) (agrp_SchoolofMedicine_ITEHP)
X-BEDEWORK-IMAGE:/public/Images/Untitled design (2)_20231228071040PM.png
X-BEDEWORK-THUMB-IMAGE:/public/Images/Untitled design (2)_20231228071040PM
 -thumb.png
END:VEVENT
BEGIN:VEVENT

CATEGORIES:Medicine
CATEGORIES:Natural Sciences
CATEGORIES:Lectures/Conferences
CATEGORIES:Utilities
CATEGORIES:Health/Wellness
CATEGORIES:Lecture/Talk
CATEGORIES:Panel/Seminar/Colloquium
CATEGORIES:Research
CATEGORIES:Main
CONTACT;X-BEDEWORK-UID=8a028ad1-899cba17-0189-d5fdf440-0000488b:Straehle\,
  Jessica
CREATED:20231228T193749Z
DESCRIPTION:This talk will address the impact of several emerging contamin
 ants (such as bisphenol S and F\, triphenyl phosphate\, and PFHxS & PFOA)
  on embryonic development in the zebrafish model. For each contaminant\, 
 this talk will address the behavioral\, phenotypic\, and gene expression 
 patterns resultant from these early embryonic exposures.\n\nTHIS IS A HYB
 RID SEMINAR WITH IN-PERSON & REMOTE ATTENDANCE OPTIONS.\nThis seminar wil
 l be held in Field Auditorium (room 1112)\, Grainger Hall.\nVisit the sem
 inar website for a livestream link to tune in virtually.\nBoth attendance
  options (in person and virtual) are free and open to all.
DURATION:PT1H15M
DTSTAMP:20231228T193749Z
DTSTART;TZID=America/New_York:20240125T140000
LAST-MODIFIED:20231228T193749Z
LOCATION;X-BEDEWORK-UID=8a0870ee-47c7da7d-0147-edb93ef0-00004d1e:Grainger 
 Hall 1112
STATUS:CONFIRMED
SUMMARY:Emerging Environmental Contaminants and Their Impact on Embryonic 
 Development
UID:CAL-8a018ccf-8b87f80e-018c-b1eedce0-00001c64demobedework@mysite.edu
URL:https://sites.nicholas.duke.edu/envhealth/seminars-symposia/spring-202
 4-seminar-series/january-25-2024-emerging-environmental-contaminants-and-
 their-impact-on-embryonic-development/
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili
 ties/Main
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us
 er/Lectures_Conferences/Lecture_Talk
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Panel_Seminar_Colloquium:/us
 er/public-user/Lectures_Conferences/Panel_Seminar_Colloquium
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Health_Wellness:/user/public
 -user/Topics/Health_Wellness
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi
 c-user/Topics/Natural Sciences
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T
 opics/Research
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Medicine:/user/public-user/T
 opics/Medicine
X-BEDEWORK-CS;X-BEDEWORK-PARAM-DESCRIPTION="/principals/users/agrp_NSOE,":
 Nicholas School of the Environment
X-BEDEWORK-SPEAKER:Larissa Williams\, PhD\, Bates College
X-BEDEWORK-DUKE-SERIES: Integrated Toxicology & Environmental Health Semin
 ar Series
X-BEDEWORK-IMAGE-X1:0
X-BEDEWORK-IMAGE-Y1:-0.3333333333333144
X-BEDEWORK-IMAGE-X2:530
X-BEDEWORK-IMAGE-Y2:353
X-BEDEWORK-IMAGE-CROP-WIDTH:530
X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333
X-BEDEWORK-IMAGE-ALT-TEXT:Seminar speaker\, Larissa Williams
X-BEDEWORK-SUBMITTEDBY:jls265 for Integrated Toxicology & Environmental He
 alth (ITEHP) (agrp_SchoolofMedicine_ITEHP)
X-BEDEWORK-IMAGE:/public/Images/LarissaWilliamsPhoto_20231228073750PM.png
X-BEDEWORK-THUMB-IMAGE:/public/Images/LarissaWilliamsPhoto_20231228073750P
 M-thumb.png
END:VEVENT
BEGIN:VEVENT

CATEGORIES:Medicine
CATEGORIES:Natural Sciences
CATEGORIES:Lectures/Conferences
CATEGORIES:Utilities
CATEGORIES:Health/Wellness
CATEGORIES:Lecture/Talk
CATEGORIES:Panel/Seminar/Colloquium
CATEGORIES:Research
CATEGORIES:Main
CONTACT;X-BEDEWORK-UID=8a028ad1-899cba17-0189-d5fdf440-0000488b:Straehle\,
  Jessica
CREATED:20231228T195513Z
DESCRIPTION:RAS genes are commonly mutated in human cancer\, which is well
  established to initiate and promote tumorigenesis.  Despite there being 
 over 50 possible such 'oncogenic' mutations in these genes\, each cancer 
 type has a tropism towards a specific and often unique subset of these mu
 tations.  As RAS mutations typically occur early during tumorigenesis\, i
 f not being the initiating mutation\, these mutational patterns ostensibl
 y reflect fundamental biology underlying the process of tumor initiation.
   Thus\, elucidating the mechanisms behind RAS mutation tropism will prov
 ide insight into one of the most foundational questions in cancer biology
  - how cancer originates - which has predictive and even preventative cli
 nical implications. To determine how these patterns are established\, the
  initiating mutagenic event has to be captured in normal cells in vivo at
  the moment they occur.  It is challenging\, if not impossible\, to ident
 ify a spontaneous mutagenic event in one RAS gene in a single specific no
 rmal cell decades before manifesting as cancer in humans.  However\, the 
 environmental carcinogen urethane exhibits a profound specificity for pul
 monary tumors driven by a single specific RAS in mice. To elucidate the p
 rinciples underlying this RAS mutation tropism of this carcinogen\, we ad
 apted an error-corrected\, high-throughput sequencing approach to detect 
 mutations in murine Ras genes at great sensitivity. This analysis not onl
 y captured the initiating Kras mutation days after urethane exposure\, bu
 t revealed that the sequence specificity of urethane mutagenesis\, couple
 d with transcription and isoform locus\, to be major influences on the ex
 treme tropism of this carcinogen.\n\nDr. Counter is the George Barth Gell
 er Distinguished Professor of Pharmacology and the Associate Director of 
 the Duke Cancer Institute. His laboratory studies the origins of human ca
 ncers.
DURATION:PT1H15M
DTSTAMP:20231228T195513Z
DTSTART;TZID=America/New_York:20240201T120000
LAST-MODIFIED:20231228T195513Z
LOCATION;X-BEDEWORK-UID=8a0870ee-47c7da7d-0147-edb93ef0-00004d1e:Grainger 
 Hall 1112
STATUS:CONFIRMED
SUMMARY:RAS mutation tropism
UID:CAL-8a018ccf-8b87f80e-018c-b1fec8d6-00001c65demobedework@mysite.edu
URL:https://sites.nicholas.duke.edu/envhealth/seminars-symposia/spring-202
 4-seminar-series/february-1-2024-ras-mutation-tropism/
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili
 ties/Main
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us
 er/Lectures_Conferences/Lecture_Talk
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Panel_Seminar_Colloquium:/us
 er/public-user/Lectures_Conferences/Panel_Seminar_Colloquium
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T
 opics/Research
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi
 c-user/Topics/Natural Sciences
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Medicine:/user/public-user/T
 opics/Medicine
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Health_Wellness:/user/public
 -user/Topics/Health_Wellness
X-BEDEWORK-CS;X-BEDEWORK-PARAM-DESCRIPTION="/principals/users/agrp_NSOE,":
 Nicholas School of the Environment
X-BEDEWORK-SPEAKER:Christopher Counter
X-BEDEWORK-DUKE-SERIES:Integrated Toxicology & Environmental Health Semina
 r Series
X-BEDEWORK-IMAGE-X1:0
X-BEDEWORK-IMAGE-Y1:-0.3333333333333144
X-BEDEWORK-IMAGE-X2:530
X-BEDEWORK-IMAGE-Y2:353
X-BEDEWORK-IMAGE-CROP-WIDTH:530
X-BEDEWORK-IMAGE-CROP-HEIGHT:353.3333333333333
X-BEDEWORK-IMAGE-ALT-TEXT:Seminar speaker\, Christopher Counter
X-BEDEWORK-SUBMITTEDBY:jls265 for Integrated Toxicology & Environmental He
 alth (ITEHP) (agrp_SchoolofMedicine_ITEHP)
X-BEDEWORK-IMAGE:/public/Images/PhotoCounter_20231228075513PM.png
X-BEDEWORK-THUMB-IMAGE:/public/Images/PhotoCounter_20231228075513PM-thumb.
 png
END:VEVENT
END:VCALENDAR