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BEGIN:VEVENT

CATEGORIES:Lectures/Conferences
CATEGORIES:Utilities
CATEGORIES:Lecture/Talk
CATEGORIES:Research
CATEGORIES:Main
CONTACT;X-BEDEWORK-UID=8a087089-35e3fb8e-0136-59bd57dc-0000557a:Schreiber\
 , Tanya
CREATED:20221107T155530Z
DESCRIPTION:The prefrontal cortex (PFC) has been dubbed the "doer cortex" 
 with a primary role of representing and selecting purposeful actions.  In
  the context of psychiatric disorders\, much of the neuronal data and com
 putational work on the PFC encoding of behavior focuses on the representa
 tion (or perception) of internal and external events that precede these a
 ctions. We have been interested in the encoding of goal-directed actions 
 per se by PFC neurons and how it is affected by anxiety. The focus on anx
 iety stems from the fact that its relevance to mental health extends well
  beyond anxiety disorders. Critically\, anxiety is a debilitating symptom
  of most psychiatric disorders including PTSD\, major depression\, autism
 \, schizophrenia and addiction. Anxiety is often studied as a stand-alone
  construct in laboratory animals that focuses on fear responses. But in t
 he context of coping with real-life anxiety\, its negative impacts extend
  beyond aversive feelings to involve disruptions in ongoing goal-directed
  behaviors and cognitive functioning. I will present data from two distin
 ct models of anxiety that allowed us to perform ensemble and local field 
 potential recordings during reward-guided goal-directed behaviors.  We fi
 nd that anxiety diminishes the recruitment of action encoding neurons and
  the coordinated activity between PFC and dopamine neurons. These results
  provide mechanistic insight for how anxiety diminishes rule-based guidan
 ce of behavior and single out encoding of actions\, as opposed to cues or
  outcomes\, by PFC neurons as particularly vulnerable to anxiety.
DURATION:PT1H
DTSTAMP:20221215T170004Z
DTSTART;TZID=America/New_York:20230117T120000
LAST-MODIFIED:20221215T170004Z
LOCATION;X-BEDEWORK-UID=18832edc-1b31c518-011b-3d9bcda0-00000001:Bryan Res
 earch 103
STATUS:CONFIRMED
SUMMARY:Duke Neurobiology Invited Seminar: Bita Moghaddam: Translation of 
 anxiety into actions by prefrontal cortex neurons
UID:CAL-8a0183a7-83184018-0184-52cdce95-00001d7ddemobedework@mysite.edu
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili
 ties/Main
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us
 er/Lectures_Conferences/Lecture_Talk
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T
 opics/Research
X-BEDEWORK-SPEAKER:Bita Moghaddam
X-BEDEWORK-DUKE-SERIES:Neurobiology Seminar Series
X-BEDEWORK-SUBMITTEDBY:ts168 for Neurobiology (agrp_SchoolofMedicine_Neuro
 biology)
END:VEVENT
END:VCALENDAR