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BEGIN:VEVENT

CATEGORIES:Natural Sciences
CATEGORIES:Lectures/Conferences
CATEGORIES:Utilities
CATEGORIES:Lecture/Talk
CATEGORIES:Main
CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None
CREATED:20230828T003217Z
DESCRIPTION:The Department of Chemistry is excited to host Casey Londergan
  (Haverford)\n\nProtein Dynamics via Vibrational Probe Groups: Untangling
  the Conformational Distribution\n\nProteins' natural functions are tied 
 up in their dynamic motions\, which are often not directly reported by co
 nventional structural biology techniques.  Vibrational spectroscopy (IR a
 bsorption and Raman scattering) can provide signals with intrinsic time r
 esolution that enables reporting on all of a protein's dynamically interc
 hanging structures\, and a variety of probe groups have been developed to
  work around the problem of spectral congestion in biomolecular vibration
 al spectra.  These probe groups\, which are often located on artificial a
 mino acid side chains\, tend to have different reporting abilities\, sign
 al strengths\, and methods of incorporation so there is not a "one size f
 its all" solution to their application. In this talk I will focus on the 
 application of two different functional group vibrations to better unders
 tanding dynamic\, functional structural changes\, note complementary meth
 ods to verify that these groups have not perturbed their host proteins\, 
 and introduce a path forward towards using vibrational probes to determin
 e dynamic conformational ensembles by combining MD simulations\, vibratio
 nal frequency calculations\, and experimental results.\n\nTo learn more a
 bout Prof. Londergan's work\, please visit: https://www.haverford.edu/use
 rs/clonderg\n\nHosted by Kat Haas
DURATION:PT1H
DTSTAMP:20240221T152704Z
DTSTART;TZID=America/New_York:20240227T114500
LAST-MODIFIED:20240221T152704Z
LOCATION;X-BEDEWORK-UID=18832edc-1b27e154-011b-28282e22-00000037:French Fa
 mily Science Center 2237
STATUS:CONFIRMED
SUMMARY:Chemistry Seminar Presented by Prof. Casey Londergan: "Protein Dyn
 amics via Vibrational Probe Groups: Untangling the Conformational Distrib
 ution"
UID:CAL-8a0292fd-8d13410f-018d-c2fc81a0-0000707ddemobedework@mysite.edu
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili
 ties/Main
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us
 er/Lectures_Conferences/Lecture_Talk
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi
 c-user/Topics/Natural Sciences
X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che
 m Admin Office
X-BEDEWORK-SPEAKER:Casey Londergan (Haverford)
X-BEDEWORK-IMAGE-X1:0
X-BEDEWORK-IMAGE-Y1:0
X-BEDEWORK-IMAGE-X2:1450.5
X-BEDEWORK-IMAGE-Y2:967
X-BEDEWORK-IMAGE-CROP-WIDTH:1450.5
X-BEDEWORK-IMAGE-CROP-HEIGHT:967
X-BEDEWORK-IMAGE-ALT-TEXT:C. Londergan
X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry
 )
X-BEDEWORK-IMAGE:/public/Images/Casey Londergan_20240221032704PM.png
X-BEDEWORK-THUMB-IMAGE:/public/Images/Casey Londergan_20240221032704PM-thu
 mb.png
END:VEVENT
END:VCALENDAR