BEGIN:VCALENDAR
PRODID:BedeWork V3.5
VERSION:2.0
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:America/New_York
X-LIC-LOCATION:America/New_York
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20070311T020000
RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=2SU
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20071104T020000
RRULE:FREQ=YEARLY;BYMONTH=11;BYDAY=1SU
END:STANDARD
BEGIN:STANDARD
TZOFFSETFROM:-045602
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:18831118T120358
RDATE:18831118T120358
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:19180331T020000
RDATE:19180331T020000
RDATE:19190330T020000
RDATE:19200328T020000
RDATE:19210424T020000
RDATE:19220430T020000
RDATE:19230429T020000
RDATE:19240427T020000
RDATE:19250426T020000
RDATE:19260425T020000
RDATE:19270424T020000
RDATE:19280429T020000
RDATE:19290428T020000
RDATE:19300427T020000
RDATE:19310426T020000
RDATE:19320424T020000
RDATE:19330430T020000
RDATE:19340429T020000
RDATE:19350428T020000
RDATE:19360426T020000
RDATE:19370425T020000
RDATE:19380424T020000
RDATE:19390430T020000
RDATE:19400428T020000
RDATE:19410427T020000
RDATE:19460428T020000
RDATE:19470427T020000
RDATE:19480425T020000
RDATE:19490424T020000
RDATE:19500430T020000
RDATE:19510429T020000
RDATE:19520427T020000
RDATE:19530426T020000
RDATE:19540425T020000
RDATE:19550424T020000
RDATE:19560429T020000
RDATE:19570428T020000
RDATE:19580427T020000
RDATE:19590426T020000
RDATE:19600424T020000
RDATE:19610430T020000
RDATE:19620429T020000
RDATE:19630428T020000
RDATE:19640426T020000
RDATE:19650425T020000
RDATE:19660424T020000
RDATE:19670430T020000
RDATE:19680428T020000
RDATE:19690427T020000
RDATE:19700426T020000
RDATE:19710425T020000
RDATE:19720430T020000
RDATE:19730429T020000
RDATE:19740106T020000
RDATE:19750223T020000
RDATE:19760425T020000
RDATE:19770424T020000
RDATE:19780430T020000
RDATE:19790429T020000
RDATE:19800427T020000
RDATE:19810426T020000
RDATE:19820425T020000
RDATE:19830424T020000
RDATE:19840429T020000
RDATE:19850428T020000
RDATE:19860427T020000
RDATE:19870405T020000
RDATE:19880403T020000
RDATE:19890402T020000
RDATE:19900401T020000
RDATE:19910407T020000
RDATE:19920405T020000
RDATE:19930404T020000
RDATE:19940403T020000
RDATE:19950402T020000
RDATE:19960407T020000
RDATE:19970406T020000
RDATE:19980405T020000
RDATE:19990404T020000
RDATE:20000402T020000
RDATE:20010401T020000
RDATE:20020407T020000
RDATE:20030406T020000
RDATE:20040404T020000
RDATE:20050403T020000
RDATE:20060402T020000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:19181027T020000
RDATE:19181027T020000
RDATE:19191026T020000
RDATE:19201031T020000
RDATE:19210925T020000
RDATE:19220924T020000
RDATE:19230930T020000
RDATE:19240928T020000
RDATE:19250927T020000
RDATE:19260926T020000
RDATE:19270925T020000
RDATE:19280930T020000
RDATE:19290929T020000
RDATE:19300928T020000
RDATE:19310927T020000
RDATE:19320925T020000
RDATE:19330924T020000
RDATE:19340930T020000
RDATE:19350929T020000
RDATE:19360927T020000
RDATE:19370926T020000
RDATE:19380925T020000
RDATE:19390924T020000
RDATE:19400929T020000
RDATE:19410928T020000
RDATE:19450930T020000
RDATE:19460929T020000
RDATE:19470928T020000
RDATE:19480926T020000
RDATE:19490925T020000
RDATE:19500924T020000
RDATE:19510930T020000
RDATE:19520928T020000
RDATE:19530927T020000
RDATE:19540926T020000
RDATE:19551030T020000
RDATE:19561028T020000
RDATE:19571027T020000
RDATE:19581026T020000
RDATE:19591025T020000
RDATE:19601030T020000
RDATE:19611029T020000
RDATE:19621028T020000
RDATE:19631027T020000
RDATE:19641025T020000
RDATE:19651031T020000
RDATE:19661030T020000
RDATE:19671029T020000
RDATE:19681027T020000
RDATE:19691026T020000
RDATE:19701025T020000
RDATE:19711031T020000
RDATE:19721029T020000
RDATE:19731028T020000
RDATE:19741027T020000
RDATE:19751026T020000
RDATE:19761031T020000
RDATE:19771030T020000
RDATE:19781029T020000
RDATE:19791028T020000
RDATE:19801026T020000
RDATE:19811025T020000
RDATE:19821031T020000
RDATE:19831030T020000
RDATE:19841028T020000
RDATE:19851027T020000
RDATE:19861026T020000
RDATE:19871025T020000
RDATE:19881030T020000
RDATE:19891029T020000
RDATE:19901028T020000
RDATE:19911027T020000
RDATE:19921025T020000
RDATE:19931031T020000
RDATE:19941030T020000
RDATE:19951029T020000
RDATE:19961027T020000
RDATE:19971026T020000
RDATE:19981025T020000
RDATE:19991031T020000
RDATE:20001029T020000
RDATE:20011028T020000
RDATE:20021027T020000
RDATE:20031026T020000
RDATE:20041031T020000
RDATE:20051030T020000
RDATE:20061029T020000
END:STANDARD
BEGIN:STANDARD
TZOFFSETFROM:-0500
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:19200101T000000
RDATE:19200101T000000
RDATE:19420101T000000
RDATE:19460101T000000
RDATE:19670101T000000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EWT
DTSTART:19420209T020000
RDATE:19420209T020000
END:DAYLIGHT
BEGIN:DAYLIGHT
TZOFFSETFROM:-0400
TZOFFSETTO:-0400
TZNAME:EPT
DTSTART:19450814T190000
RDATE:19450814T190000
END:DAYLIGHT
END:VTIMEZONE
BEGIN:VEVENT

CATEGORIES:Natural Sciences
CATEGORIES:Lectures/Conferences
CATEGORIES:Utilities
CATEGORIES:Lecture/Talk
CATEGORIES:Main
CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None
CREATED:20241122T182316Z
DESCRIPTION:The Department of Chemistry is pleased to host Dr. Gregory Cra
 ven for a seminar on Monday\, December 2. \n\nTitle: "Mutant-selective AK
 T1 inhibition via lysine targeting and neo-zinc chelation"\n\nAbstract: M
 utations in the kinase AKT1\, especially the E17K mutation\, drive oncoge
 nic signaling in many solid tumors. In clinical studies\, pan-AKT inhibit
 ors cause dose-limiting hyperglycemia\, motivating the search for mutant-
 selective inhibitors. To address this\, I exploited the E17K mutation to 
 design allosteric\, lysine-targeted salicylaldehyde inhibitors with selec
 tivity for AKT1(E17K) over wild type AKT paralogs\, a major challenge giv
 en the presence of three conserved lysines near the allosteric site. Stru
 ctural studies revealed an unexpected mode of covalent inhibition involvi
 ng neo-zinc coordination\, which drives exceptional selectivity and resid
 ence-time in cellular models and tumor xenografts. This approach opens a 
 pathway for the selective targeting of other oncogenic lysine mutations i
 n cancer and motivates the search for new pharmacological opportunities b
 y exploiting ligand-induced metal chelation.\n\nHost: Chemistry Departmen
 t Chemical Biology Series
DURATION:PT1H
DTSTAMP:20241122T182752Z
DTSTART;TZID=America/New_York:20241202T114500
LAST-MODIFIED:20241122T182752Z
LOCATION;X-BEDEWORK-UID=18832edc-1c2ecfef-011c-481f44ec-0000030a:French Fa
 mily Science Center 4233
STATUS:CONFIRMED
SUMMARY:Chemistry Seminar Presented by Dr. Gregory Craven
UID:CAL-8a000483-92c3adf6-0193-551d30bf-0000562cdemobedework@mysite.edu
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili
 ties/Main
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us
 er/Lectures_Conferences/Lecture_Talk
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi
 c-user/Topics/Natural Sciences
X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=c.conti@duke.edu:Departm
 ent of Chemistry
X-BEDEWORK-SPEAKER:Dr. Gregory Craven\, University of California San Franc
 isco
X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series
X-BEDEWORK-IMAGE-X1:0
X-BEDEWORK-IMAGE-Y1:234
X-BEDEWORK-IMAGE-X2:1236
X-BEDEWORK-IMAGE-Y2:1058
X-BEDEWORK-IMAGE-CROP-WIDTH:1236
X-BEDEWORK-IMAGE-CROP-HEIGHT:824
X-BEDEWORK-IMAGE-ALT-TEXT:Researcher stands in red shirt in outdoor settin
 g
X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr
 y)
X-BEDEWORK-IMAGE:/public/Images/Gregory Craven2_20241122062316PM.jpg
X-BEDEWORK-THUMB-IMAGE:/public/Images/Gregory Craven2_20241122062316PM-thu
 mb.png
END:VEVENT
END:VCALENDAR