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BEGIN:VEVENT

CATEGORIES:Natural Sciences
CATEGORIES:Lectures/Conferences
CATEGORIES:Utilities
CATEGORIES:Lecture/Talk
CATEGORIES:Main
CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None
CREATED:20241125T153638Z
DESCRIPTION:The Department of Chemistry is pleased to host Dr. Nicholas Ti
 ll for a seminar on Friday\, December 13. \n\nTitle: "Mechanistic Investi
 gation of Nickel/Photoredox Catalysis and Redirecting Trogocytosis for Ta
 rgeted Protein Transfer"\n\nAbstract: Part I: Visible light photoredox ca
 talysis is a powerful method to modulate small molecule and transition me
 tal reactivity\, but we lack insight into the mechanistic basis of this t
 echnology. I will present a comprehensive study of an industrially import
 ant Nickel/photoredox catalyzed C-N cross-coupling reaction. Using a comb
 ination of reaction kinetic analysis\, ultrafast spectroscopy\, and stoic
 hiometric organometallic studies\, we elucidate the key steps in the mech
 anism of this reaction. We then leverage these insights to design a new p
 hotocatalyst yielding improved reaction rate (>30-fold) and quantum yield
  (>10-fold).\n\nPart II: Targeted degradation of cell surface proteins ca
 n address therapeutic challenges rooted in pathologic over-expression or 
 over-activation of a disease-driving protein. Directly introducing cell s
 urface proteins to address therapeutic challenges rooted in pathologic pr
 otein deficiency or dysfunction remains an unsolved challenge. I will pre
 sent the development of bispecific molecules (TrogoTACs) capable of induc
 ing contactdependent protein transfer between cells by redirecting trogoc
 ytosis in a targeted fashion. To accomplish this goal\, we designed chime
 ric antibody-small molecule conjugates with specificity to cell surface p
 roteins displaying mutually exclusive expression on donor and acceptor ce
 ll types. The protein transfer process is rapid\, requires cell-cell cont
 act\, and depends on expression of the receptors targeted by the TrogoTAC
 . Transferred proteins can then redirect T cell engager cytotoxicity to r
 ewire therapeutic targeting towards\notherwise unresponsive cancer cells.
 \n\nHost: Chemistry Department Chemical Biology Series
DURATION:PT1H
DTSTAMP:20241125T153638Z
DTSTART;TZID=America/New_York:20241213T121500
LAST-MODIFIED:20241125T153638Z
LOCATION;X-BEDEWORK-UID=18832edc-1c2ecfef-011c-481f44ec-0000030a:French Fa
 mily Science Center 4233
STATUS:CONFIRMED
SUMMARY:Chemistry Seminar Presented by Dr. Nicholas Till
UID:CAL-8a000483-92c3adf6-0193-63f7b542-00006eb2demobedework@mysite.edu
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili
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X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us
 er/Lectures_Conferences/Lecture_Talk
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi
 c-user/Topics/Natural Sciences
X-BEDEWORK-SPEAKER:Dr. Nicholas Till\, Stanford University
X-BEDEWORK-DUKE-SERIES:Department of Chemistry Seminar
X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=c.conti@duke.edu:Departm
 ent of Chemistry
X-BEDEWORK-IMAGE-X1:0
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X-BEDEWORK-IMAGE-ALT-TEXT:Researcher stands in a navy blue jacket and ligh
 t blue shirt in an outdoor setting
X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr
 y)
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END:VEVENT
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