BEGIN:VCALENDAR
PRODID:BedeWork V3.5
VERSION:2.0
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:America/New_York
X-LIC-LOCATION:America/New_York
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20070311T020000
RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=2SU
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20071104T020000
RRULE:FREQ=YEARLY;BYMONTH=11;BYDAY=1SU
END:STANDARD
BEGIN:STANDARD
TZOFFSETFROM:-045602
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:18831118T120358
RDATE:18831118T120358
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:19180331T020000
RDATE:19180331T020000
RDATE:19190330T020000
RDATE:19200328T020000
RDATE:19210424T020000
RDATE:19220430T020000
RDATE:19230429T020000
RDATE:19240427T020000
RDATE:19250426T020000
RDATE:19260425T020000
RDATE:19270424T020000
RDATE:19280429T020000
RDATE:19290428T020000
RDATE:19300427T020000
RDATE:19310426T020000
RDATE:19320424T020000
RDATE:19330430T020000
RDATE:19340429T020000
RDATE:19350428T020000
RDATE:19360426T020000
RDATE:19370425T020000
RDATE:19380424T020000
RDATE:19390430T020000
RDATE:19400428T020000
RDATE:19410427T020000
RDATE:19460428T020000
RDATE:19470427T020000
RDATE:19480425T020000
RDATE:19490424T020000
RDATE:19500430T020000
RDATE:19510429T020000
RDATE:19520427T020000
RDATE:19530426T020000
RDATE:19540425T020000
RDATE:19550424T020000
RDATE:19560429T020000
RDATE:19570428T020000
RDATE:19580427T020000
RDATE:19590426T020000
RDATE:19600424T020000
RDATE:19610430T020000
RDATE:19620429T020000
RDATE:19630428T020000
RDATE:19640426T020000
RDATE:19650425T020000
RDATE:19660424T020000
RDATE:19670430T020000
RDATE:19680428T020000
RDATE:19690427T020000
RDATE:19700426T020000
RDATE:19710425T020000
RDATE:19720430T020000
RDATE:19730429T020000
RDATE:19740106T020000
RDATE:19750223T020000
RDATE:19760425T020000
RDATE:19770424T020000
RDATE:19780430T020000
RDATE:19790429T020000
RDATE:19800427T020000
RDATE:19810426T020000
RDATE:19820425T020000
RDATE:19830424T020000
RDATE:19840429T020000
RDATE:19850428T020000
RDATE:19860427T020000
RDATE:19870405T020000
RDATE:19880403T020000
RDATE:19890402T020000
RDATE:19900401T020000
RDATE:19910407T020000
RDATE:19920405T020000
RDATE:19930404T020000
RDATE:19940403T020000
RDATE:19950402T020000
RDATE:19960407T020000
RDATE:19970406T020000
RDATE:19980405T020000
RDATE:19990404T020000
RDATE:20000402T020000
RDATE:20010401T020000
RDATE:20020407T020000
RDATE:20030406T020000
RDATE:20040404T020000
RDATE:20050403T020000
RDATE:20060402T020000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:19181027T020000
RDATE:19181027T020000
RDATE:19191026T020000
RDATE:19201031T020000
RDATE:19210925T020000
RDATE:19220924T020000
RDATE:19230930T020000
RDATE:19240928T020000
RDATE:19250927T020000
RDATE:19260926T020000
RDATE:19270925T020000
RDATE:19280930T020000
RDATE:19290929T020000
RDATE:19300928T020000
RDATE:19310927T020000
RDATE:19320925T020000
RDATE:19330924T020000
RDATE:19340930T020000
RDATE:19350929T020000
RDATE:19360927T020000
RDATE:19370926T020000
RDATE:19380925T020000
RDATE:19390924T020000
RDATE:19400929T020000
RDATE:19410928T020000
RDATE:19450930T020000
RDATE:19460929T020000
RDATE:19470928T020000
RDATE:19480926T020000
RDATE:19490925T020000
RDATE:19500924T020000
RDATE:19510930T020000
RDATE:19520928T020000
RDATE:19530927T020000
RDATE:19540926T020000
RDATE:19551030T020000
RDATE:19561028T020000
RDATE:19571027T020000
RDATE:19581026T020000
RDATE:19591025T020000
RDATE:19601030T020000
RDATE:19611029T020000
RDATE:19621028T020000
RDATE:19631027T020000
RDATE:19641025T020000
RDATE:19651031T020000
RDATE:19661030T020000
RDATE:19671029T020000
RDATE:19681027T020000
RDATE:19691026T020000
RDATE:19701025T020000
RDATE:19711031T020000
RDATE:19721029T020000
RDATE:19731028T020000
RDATE:19741027T020000
RDATE:19751026T020000
RDATE:19761031T020000
RDATE:19771030T020000
RDATE:19781029T020000
RDATE:19791028T020000
RDATE:19801026T020000
RDATE:19811025T020000
RDATE:19821031T020000
RDATE:19831030T020000
RDATE:19841028T020000
RDATE:19851027T020000
RDATE:19861026T020000
RDATE:19871025T020000
RDATE:19881030T020000
RDATE:19891029T020000
RDATE:19901028T020000
RDATE:19911027T020000
RDATE:19921025T020000
RDATE:19931031T020000
RDATE:19941030T020000
RDATE:19951029T020000
RDATE:19961027T020000
RDATE:19971026T020000
RDATE:19981025T020000
RDATE:19991031T020000
RDATE:20001029T020000
RDATE:20011028T020000
RDATE:20021027T020000
RDATE:20031026T020000
RDATE:20041031T020000
RDATE:20051030T020000
RDATE:20061029T020000
END:STANDARD
BEGIN:STANDARD
TZOFFSETFROM:-0500
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:19200101T000000
RDATE:19200101T000000
RDATE:19420101T000000
RDATE:19460101T000000
RDATE:19670101T000000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EWT
DTSTART:19420209T020000
RDATE:19420209T020000
END:DAYLIGHT
BEGIN:DAYLIGHT
TZOFFSETFROM:-0400
TZOFFSETTO:-0400
TZNAME:EPT
DTSTART:19450814T190000
RDATE:19450814T190000
END:DAYLIGHT
END:VTIMEZONE
BEGIN:VEVENT

CATEGORIES:Natural Sciences
CATEGORIES:Lectures/Conferences
CATEGORIES:Utilities
CATEGORIES:Lecture/Talk
CATEGORIES:Main
CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None
CREATED:20241127T044538Z
DESCRIPTION:The Department of Chemistry is pleased to host Dr. Carly Schis
 sel for a seminar on Wednesday\, December 11.\n\nTitle: "Strategies to Di
 scover\, Design\, and Synthesize Unnatural Bioactive Peptides"\n\nAbstrac
 t: Peptide therapeutics are a rapidly expanding frontier in drug developm
 ent. New methods that address challenges in the discovery\, design\, and 
 synthesis of bioactive peptides are needed to advance these molecules as 
 medicines. One of the most important roadblocks that macromolecular drugs
  face is their inability to reach intracellular targets. I will demonstra
 te new approaches for the design and synthesis of unnatural bioactive pep
 tides. First\, we used machine learning for the de novo design of nuclear
 -targeting miniproteins to traffic macromolecular cargo to the nucleus of
  cells. We found that the model was able to predict new sequences with ac
 tivities extrapolated beyond the training dataset\, resulting in the most
  active variants yet. Next\, we demonstrated a method for in-cell penetra
 tion selection-mass spectrometry to discover cytosol-targeting peptides f
 rom a synthetic library. Novel unnatural sequences found from the cytosol
  trafficked oligonucleotide cargo to the nucleus better than those found 
 in whole cell extracts. A key outcome of these efforts was that the prese
 nce of unnatural amino acids with extended backbones conferred enhanced b
 ioactivity. The ribosomal synthesis of proteins and peptides with unnatur
 al peptide backbones is thus of critical importance. In the second part o
 f the presentation\, we developed post-translational acyl shift reactions
  to install internal diketones\, heterocycles\, and extended backbones in
  ribosomal peptides and proteins. These works advance the therapeutic pot
 ential of peptides by both developing new bioactive sequences and enablin
 g their biological synthesis.\n\nHost: Chemistry Department Chemical Biol
 ogy Series
DURATION:PT1H
DTSTAMP:20241127T044538Z
DTSTART;TZID=America/New_York:20241211T121500
LAST-MODIFIED:20241127T044538Z
LOCATION;X-BEDEWORK-UID=18832edc-1c2ecfef-011c-481f44ec-0000030a:French Fa
 mily Science Center 4233
STATUS:CONFIRMED
SUMMARY:Chemistry Seminar Presented by Dr. Carly Schissel
UID:CAL-8a000483-92c3adf6-0193-6bf06dca-00000fdedemobedework@mysite.edu
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili
 ties/Main
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us
 er/Lectures_Conferences/Lecture_Talk
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi
 c-user/Topics/Natural Sciences
X-BEDEWORK-SPEAKER:Dr. Carly Schissel\, University of California\, Berkele
 y
X-BEDEWORK-DUKE-SERIES:Chemistry Seminar Series
X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=c.conti@duke.edu:Departm
 ent of Chemistry
X-BEDEWORK-IMAGE-X1:0
X-BEDEWORK-IMAGE-Y1:123
X-BEDEWORK-IMAGE-X2:960
X-BEDEWORK-IMAGE-Y2:763
X-BEDEWORK-IMAGE-CROP-WIDTH:960
X-BEDEWORK-IMAGE-CROP-HEIGHT:640
X-BEDEWORK-IMAGE-ALT-TEXT:Researcher stands in a black and white polka dot
  shirt in glasses against a concrete wall
X-BEDEWORK-SUBMITTEDBY:cconti for Chemistry (agrp_ArtsandSciences_Chemistr
 y)
X-BEDEWORK-IMAGE:/public/Images/Schissel_20241127044538AM.jpg
X-BEDEWORK-THUMB-IMAGE:/public/Images/Schissel_20241127044538AM-thumb.png
END:VEVENT
END:VCALENDAR