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BEGIN:VEVENT

CATEGORIES:Medicine
CATEGORIES:Engineering
CATEGORIES:Lectures/Conferences
CATEGORIES:Utilities
CATEGORIES:Lecture/Talk
CATEGORIES:Panel/Seminar/Colloquium
CATEGORIES:Research
CATEGORIES:Main
CONTACT;X-BEDEWORK-UID=2c918083-7c1b2592-017c-3493015d-00002106:Kane\, Mic
 haela
CREATED:20250324T185431Z
DESCRIPTION:Steven Chu is the William R. Kenan\, Jr. Professor of Physics\
 , of Molecular and Cellular Physiology\, and of Energy Science and Engine
 ering at Stanford University. He received the 1997 Nobel Prize in Physics
  for laser cooling and trapping of atoms. Other contributions include the
  first optical tweezers\nmanipulation of biomolecules\, precision atom in
 terferometry based on optical pulses of light\, and single molecule FRET 
 of biomolecules tethered to surfaces. He is now developing and applying n
 ew methods in molecular biology and medical imaging\, materials science\,
  and batteries. Previously he was U.S. Secretary of Energy\, where he beg
 an ARPA-E\, the Energy Innovation Hubs\, and was tasked by\nPresident Oba
 ma to help BP stop the Macondo Oil spill. Previously\, he was Director of
  Lawrence Berkeley National Laboratory and Professor of Physics and Appli
 ed Physics at Stanford\, and helped initiate Bio-X\, which linked the phy
 sical and biological sciences with engineering and medicine. Before Stanf
 ord\, he was a department head at Bell Laboratories. He was past presiden
 t of the American Association for the Advancement of Science\, a Senior A
 dvisor to the Directors of the NIH and the NSA.\n\nWhat can be learned by
  tracking the motion of cargos due to dynein in live cells with milliseco
 nd and microsecond time resolution and sub-nanometer spatial\nresolution?
 \n\nWe have measured to the transport of molecular cargos in neuronal cel
 ls with 1 millisecond time resolution and 4 nm spatial resolution. Our de
 velopment of very bright optical probes enabled the long-term single trac
 king of molecular cargos.\nOur probes allowed individual molecular steps 
 to be resolved at cellular ATP concentrations (three orders of magnitude 
 higher than the in vitro studies)\, and led to a new\, detailed quantitat
 ively falsifiable chemo-mechanical model where two ATP molecules are hydr
 olyzed sequentially. A model of how this motor cleverly uses thermal fluc
 tuations to produce move molecular cargos will be discussed. More recentl
 y\, we have improved the tracking resolution to ~1 us time resolution wit
 h 0.3 nm spatial resolution to test the predictions of our new\nmodel of 
 how dynein operates. The first results of this new work\, and what it can
  tell us about the molecular biology and biophysics of this motor will\nb
 e discussed.
DURATION:PT1H
DTSTAMP:20250424T194650Z
DTSTART;TZID=America/New_York:20250403T150000
LAST-MODIFIED:20250424T194650Z
LOCATION;X-BEDEWORK-UID=2c918083-7c1b2592-017c-343e7a30-00001f55:Wilkinson
  Building\, room 021 auditorium
STATUS:CONFIRMED
SUMMARY:BME Distinguished Seminar Series with Steven Chu
UID:CAL-8a000483-92c3adf6-0195-c981a66b-0000489cdemobedework@mysite.edu
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili
 ties/Main
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Panel_Seminar_Colloquium:/us
 er/public-user/Lectures_Conferences/Panel_Seminar_Colloquium
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us
 er/Lectures_Conferences/Lecture_Talk
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Engineering:/user/public-use
 r/Topics/Engineering
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 opics/Research
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 opics/Medicine
X-BEDEWORK-CS;X-BEDEWORK-PARAM-DESCRIPTION="/principals/users/agrp_NSOE_Ni
 cholasInstituteforEnvironmentalPolicySolutions,/principals/users/agrp_Sch
 oolofMedicine,/principals/users/agrp__ArtsandSciences_TrinityCollege,":Ni
 cholas Institute for Energy\, Environment and Sustainability\,School of M
 edicine (SOM)\,Trinity College
X-BEDEWORK-SPEAKER:Steven Chu
X-BEDEWORK-DUKE-SERIES:BME Distinguished Seminar Series
X-BEDEWORK-SUBMITTEDBY:mlk47 for Biomedical Engineering (BME) (agrp_PrattS
 chool_BME)
END:VEVENT
END:VCALENDAR