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BEGIN:VEVENT

CATEGORIES:Natural Sciences
CATEGORIES:Lectures/Conferences
CATEGORIES:Utilities
CATEGORIES:Lecture/Talk
CATEGORIES:Research
CATEGORIES:Main
CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None
CREATED:20250710T152114Z
DESCRIPTION:Enriched Spatiotemporal Mapping of Single-Virus Dynamics in Ce
 llular and Complex Environment via High-Speed 3D Tracking Microscopy\n\nV
 iral infection is a highly dynamic process spanning molecular to tissue s
 cales\, posing persistent challenges for real-time\, high-resolution imag
 ing. This dissertation presents advancements in high-speed 3D tracking mi
 croscopy and photostable labeling to enable enriched spatiotemporal mappi
 ng of single-virus dynamics in both cellular and complex environments. We
  developed 3D-TrIm microscopy\, combining active-feedback single-particle
  tracking with simultaneous volumetric imaging\, to resolve viral behavio
 rs such as membrane skimming\, receptor binding\, and intercellular traff
 icking in live cells and tissue-like systems. To extend tracking duration
 \, photostable StayGold-labelled virus-like particles were engineered\, a
 chieving continuous\, kilohertz-rate 3D tracking for over an hour. Integr
 ating these tools\, we investigated SARS-CoV-2 infection dynamics and unc
 overed a previously unreported actin-dependent viral membrane trafficking
  behavior associated with ACE2 expression. Finally\, we applied single pa
 rticle tracking microscopy to study nanoparticle diffusion in 3D porous h
 ydrogels\, revealing heterogeneous transport modes and confinement dynami
 cs\, offering insights into material microstructure and particle transpor
 t relevant to biological and biomedical applications.
DURATION:PT1H
DTSTAMP:20250710T152114Z
DTSTART;TZID=America/New_York:20250714T130000
LAST-MODIFIED:20250710T152114Z
LOCATION;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf6e-00000000:None
STATUS:CONFIRMED
SUMMARY:Chemistry Defense: Yuxin Lin: Enriched Spatiotemporal Mapping of S
 ingle-Virus Dynamics in Cellular and Complex Environment via High-Speed 3
 D Tracking Microscopy
UID:CAL-8a00ec8b-979413b9-0197-f4ed3039-00000cc1demobedework@mysite.edu
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X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us
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X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T
 opics/Research
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi
 c-user/Topics/Natural Sciences
X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=Chem-office@duke.edu:Che
 m Admin Office
X-BEDEWORK-LOCATION:French Family Science Center 2219
X-BEDEWORK-IMAGE-X1:692
X-BEDEWORK-IMAGE-Y1:323
X-BEDEWORK-IMAGE-X2:1222
X-BEDEWORK-IMAGE-Y2:676.3333333333333
X-BEDEWORK-IMAGE-CROP-WIDTH:530
X-BEDEWORK-IMAGE-CROP-HEIGHT:353.33333333333326
X-BEDEWORK-IMAGE-ALT-TEXT:YL
X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry
 )
X-BEDEWORK-IMAGE:/public/Images/Yuxin Lin 2_20250710032114PM.png
X-BEDEWORK-THUMB-IMAGE:/public/Images/Yuxin Lin 2_20250710032114PM-thumb.p
 ng
END:VEVENT
END:VCALENDAR