BEGIN:VCALENDAR
PRODID:BedeWork V3.5
VERSION:2.0
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:America/New_York
X-LIC-LOCATION:America/New_York
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20070311T020000
RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=2SU
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20071104T020000
RRULE:FREQ=YEARLY;BYMONTH=11;BYDAY=1SU
END:STANDARD
BEGIN:STANDARD
TZOFFSETFROM:-045602
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:18831118T120358
RDATE:18831118T120358
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:19180331T020000
RDATE:19180331T020000
RDATE:19190330T020000
RDATE:19200328T020000
RDATE:19210424T020000
RDATE:19220430T020000
RDATE:19230429T020000
RDATE:19240427T020000
RDATE:19250426T020000
RDATE:19260425T020000
RDATE:19270424T020000
RDATE:19280429T020000
RDATE:19290428T020000
RDATE:19300427T020000
RDATE:19310426T020000
RDATE:19320424T020000
RDATE:19330430T020000
RDATE:19340429T020000
RDATE:19350428T020000
RDATE:19360426T020000
RDATE:19370425T020000
RDATE:19380424T020000
RDATE:19390430T020000
RDATE:19400428T020000
RDATE:19410427T020000
RDATE:19460428T020000
RDATE:19470427T020000
RDATE:19480425T020000
RDATE:19490424T020000
RDATE:19500430T020000
RDATE:19510429T020000
RDATE:19520427T020000
RDATE:19530426T020000
RDATE:19540425T020000
RDATE:19550424T020000
RDATE:19560429T020000
RDATE:19570428T020000
RDATE:19580427T020000
RDATE:19590426T020000
RDATE:19600424T020000
RDATE:19610430T020000
RDATE:19620429T020000
RDATE:19630428T020000
RDATE:19640426T020000
RDATE:19650425T020000
RDATE:19660424T020000
RDATE:19670430T020000
RDATE:19680428T020000
RDATE:19690427T020000
RDATE:19700426T020000
RDATE:19710425T020000
RDATE:19720430T020000
RDATE:19730429T020000
RDATE:19740106T020000
RDATE:19750223T020000
RDATE:19760425T020000
RDATE:19770424T020000
RDATE:19780430T020000
RDATE:19790429T020000
RDATE:19800427T020000
RDATE:19810426T020000
RDATE:19820425T020000
RDATE:19830424T020000
RDATE:19840429T020000
RDATE:19850428T020000
RDATE:19860427T020000
RDATE:19870405T020000
RDATE:19880403T020000
RDATE:19890402T020000
RDATE:19900401T020000
RDATE:19910407T020000
RDATE:19920405T020000
RDATE:19930404T020000
RDATE:19940403T020000
RDATE:19950402T020000
RDATE:19960407T020000
RDATE:19970406T020000
RDATE:19980405T020000
RDATE:19990404T020000
RDATE:20000402T020000
RDATE:20010401T020000
RDATE:20020407T020000
RDATE:20030406T020000
RDATE:20040404T020000
RDATE:20050403T020000
RDATE:20060402T020000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:19181027T020000
RDATE:19181027T020000
RDATE:19191026T020000
RDATE:19201031T020000
RDATE:19210925T020000
RDATE:19220924T020000
RDATE:19230930T020000
RDATE:19240928T020000
RDATE:19250927T020000
RDATE:19260926T020000
RDATE:19270925T020000
RDATE:19280930T020000
RDATE:19290929T020000
RDATE:19300928T020000
RDATE:19310927T020000
RDATE:19320925T020000
RDATE:19330924T020000
RDATE:19340930T020000
RDATE:19350929T020000
RDATE:19360927T020000
RDATE:19370926T020000
RDATE:19380925T020000
RDATE:19390924T020000
RDATE:19400929T020000
RDATE:19410928T020000
RDATE:19450930T020000
RDATE:19460929T020000
RDATE:19470928T020000
RDATE:19480926T020000
RDATE:19490925T020000
RDATE:19500924T020000
RDATE:19510930T020000
RDATE:19520928T020000
RDATE:19530927T020000
RDATE:19540926T020000
RDATE:19551030T020000
RDATE:19561028T020000
RDATE:19571027T020000
RDATE:19581026T020000
RDATE:19591025T020000
RDATE:19601030T020000
RDATE:19611029T020000
RDATE:19621028T020000
RDATE:19631027T020000
RDATE:19641025T020000
RDATE:19651031T020000
RDATE:19661030T020000
RDATE:19671029T020000
RDATE:19681027T020000
RDATE:19691026T020000
RDATE:19701025T020000
RDATE:19711031T020000
RDATE:19721029T020000
RDATE:19731028T020000
RDATE:19741027T020000
RDATE:19751026T020000
RDATE:19761031T020000
RDATE:19771030T020000
RDATE:19781029T020000
RDATE:19791028T020000
RDATE:19801026T020000
RDATE:19811025T020000
RDATE:19821031T020000
RDATE:19831030T020000
RDATE:19841028T020000
RDATE:19851027T020000
RDATE:19861026T020000
RDATE:19871025T020000
RDATE:19881030T020000
RDATE:19891029T020000
RDATE:19901028T020000
RDATE:19911027T020000
RDATE:19921025T020000
RDATE:19931031T020000
RDATE:19941030T020000
RDATE:19951029T020000
RDATE:19961027T020000
RDATE:19971026T020000
RDATE:19981025T020000
RDATE:19991031T020000
RDATE:20001029T020000
RDATE:20011028T020000
RDATE:20021027T020000
RDATE:20031026T020000
RDATE:20041031T020000
RDATE:20051030T020000
RDATE:20061029T020000
END:STANDARD
BEGIN:STANDARD
TZOFFSETFROM:-0500
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:19200101T000000
RDATE:19200101T000000
RDATE:19420101T000000
RDATE:19460101T000000
RDATE:19670101T000000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EWT
DTSTART:19420209T020000
RDATE:19420209T020000
END:DAYLIGHT
BEGIN:DAYLIGHT
TZOFFSETFROM:-0400
TZOFFSETTO:-0400
TZNAME:EPT
DTSTART:19450814T190000
RDATE:19450814T190000
END:DAYLIGHT
END:VTIMEZONE
BEGIN:VEVENT

CATEGORIES:Medicine
CATEGORIES:Engineering
CATEGORIES:Natural Sciences
CATEGORIES:Lectures/Conferences
CATEGORIES:Utilities
CATEGORIES:Lecture/Talk
CATEGORIES:Panel/Seminar/Colloquium
CATEGORIES:Research
CATEGORIES:Technology
CATEGORIES:Main
CONTACT;X-BEDEWORK-UID=8a0183a7-83184018-0184-f88b4dd1-00001a24:Franklin\,
  Monica
CREATED:20230805T023014Z
DESCRIPTION:Multi-omics data\, increasingly available in epidemiological c
 ohorts with rich phenotype data\, pose grand opportunities and challenges
 . Harnessing the power of deep learning and multi-modal large language mo
 dels holds great promises for multi-omics integration. I will first intro
 duce our novel method OMEGA\, Omics Multi-modality Embedding via Graphica
 l & Articulated data\, for multi-omics integration by simultaneously cons
 idering image\, text and tabular representations of omics data. We applie
 d our models to 17 incident clinical endpoints in 23\,776 UK Biobank indi
 viduals with 159 metabolites (NMR based Nightingale platform) and 2\,923 
 proteins (Affinity-based Olink 3k proteomics). Our OMEGA models outperfor
 med alternatives including mixOmics and MOGONET.\n\nSpatial transcriptomi
 cs (ST) technologies have revolutionized our ability to study gene expres
 sion within the spatial context of tissues. Spatial variable genes (SVGs)
 \, revealing critical information and about tissue architecture\, cellula
 r interactions\, and disease-relevant microenvironments\, are of keen int
 erest in ST studies. We performed a comprehensive benchmarking study of 2
 0 state-of-the-art SVG detection methods using >600 human slides from STi
 mage-1K4M\, a large-scale ST resource comprising >1000 slides from >18 ti
 ssue types. We also constructed the first cross-tissue atlas of SVGs\, en
 abling comparative analysis of spatial gene programs across cancer and no
 rmal tissues.
DURATION:PT1H
DTSTAMP:20251007T130223Z
DTSTART;TZID=America/New_York:20251020T120000
LAST-MODIFIED:20251007T130223Z
LOCATION;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf6e-00000000:None
STATUS:CONFIRMED
SUMMARY:Computational Methods and Resources for Multi-omics Understanding 
 of Complex Human Systems
UID:CAL-8a00ec8b-979413b9-0199-bec2c8f5-00004d8ademobedework@mysite.edu
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili
 ties/Main
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Engineering:/user/public-use
 r/Topics/Engineering
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Medicine:/user/public-user/T
 opics/Medicine
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi
 c-user/Topics/Natural Sciences
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Research:/user/public-user/T
 opics/Research
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us
 er/Lectures_Conferences/Lecture_Talk
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Panel_Seminar_Colloquium:/us
 er/public-user/Lectures_Conferences/Panel_Seminar_Colloquium
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Technology:/user/public-user
 /Topics/Technology
X-BEDEWORK-CS;X-BEDEWORK-PARAM-DESCRIPTION="/principals/users/agrp_Schoolo
 fMedicine_BiostatisticsandBioinformatics,/principals/users/agrp_Pratt_CAG
 T,/principals/users/agrp_ArtsandSciences_ComputerScience,/principals/user
 s/agrp_CenterforGenomicandComputationalBiology,/principals/users/agrp_Sch
 oolofMedicine_Microbiome,/principals/users/agrp_SchoolofMedicine,/princip
 als/users/agrp_SchoolofMedicine_UPGG,":Biostatistics and Bioinformatics\,
 Center for Advanced Genomic Technologies\,Computer Science\,Duke Center f
 or Genomic and Computational Biology (GCB)\,Duke Microbiome Center\,Schoo
 l of Medicine (SOM)\,University Program in Genetics &amp\;amp\; Genomics 
 (UPGG)
X-BEDEWORK-SPEAKER:Yun Li\, PhD
X-BEDEWORK-DUKE-SERIES:CBB Monday Seminar Series
X-BEDEWORK-IMAGE-X1:0
X-BEDEWORK-IMAGE-Y1:0
X-BEDEWORK-IMAGE-X2:529.5
X-BEDEWORK-IMAGE-Y2:353
X-BEDEWORK-IMAGE-CROP-WIDTH:529.5
X-BEDEWORK-IMAGE-CROP-HEIGHT:353
X-BEDEWORK-IMAGE-ALT-TEXT:Pictured is Dr. Yun Li\, a woman with short dark
  hair\, wearing a dark shirt smiling at the camera
X-BEDEWORK-SUBMITTEDBY:monicaf for Computational Biology and Bioinformatic
 s (CBB) (agrp_SchoolofMedicine_CBB)
X-BEDEWORK-LOCATION:French Family Science Center\, room 4233
X-BEDEWORK-IMAGE:/public/Images/Yun Li canva photo_20251007010100PM.png
X-BEDEWORK-THUMB-IMAGE:/public/Images/Yun Li canva photo_20251007010100PM-
 thumb.png
END:VEVENT
END:VCALENDAR