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BEGIN:VEVENT

CATEGORIES:Natural Sciences
CATEGORIES:Lectures/Conferences
CATEGORIES:Utilities
CATEGORIES:Lecture/Talk
CATEGORIES:Main
CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None
CREATED:20251007T135734Z
DESCRIPTION:Investigation of poly(ester urea) properties and their use tow
 ards infection control in medical devices\n\nTo this day\, there is a nee
 d for biomedical materials\, specifically as it relates to surgical impla
 nts. Poly(ester urea)s (PEUs) are a class of amorphous\, highly tunable\,
  and resorbable polymers that can cover a large window of mechanical and 
 physical properties. By focusing on a biologically compatible material th
 at is based on naturally occurring amino acids\, we can combat adverse si
 de effects\, such as inflammation\, commonly associated with other polyme
 ric devices on the market. In this work\, we synthesized and thoroughly c
 haracterized a diverse library of PEUs and performed further testing in v
 ivo with a select subset to monitor their breakdown. We were able to iden
 tify trends in degradation based on water uptake profiles. This could ult
 imately assist in improved and informed biomaterial selection moving forw
 ard.\nAdditionally\, a direct application was explored with PEUs for the 
 delivery of antibiotics. Bacterial infections pose a large threat in the 
 clinic that can lead to repeated invasive surgeries and even patient mort
 ality. Therefore\, designing a biodegradable pouch that provides controll
 ed site-specific therapy is of great interest. Our formulation focuses on
  the dual release of minocycline and rifampin which are combined with the
  polymer matrix itself. Herein\, we experiment with a valine and phenylal
 anine PEU copolymer. Our results demonstrate that the drug-loaded\, elect
 rospun nanofiber mats are effective against various strains of staphyloco
 cci species in vitro and can completely eradicate S. aureus after 14 days
  in a rabbit model. This part of the research highlights our PEU device a
 s a promising candidate for preventing infections.
DURATION:PT1H
DTSTAMP:20251007T135734Z
DTSTART;TZID=America/New_York:20251024T150000
LAST-MODIFIED:20251007T135734Z
LOCATION;X-BEDEWORK-UID=2c918083-7c1b2592-017c-343e14c6-00001f54:Wilkinson
  Building\, room 136
STATUS:CONFIRMED
SUMMARY:Chemistry Defense: Kacey Godwin: Investigation of poly(ester urea)
  properties and their use towards infection control in medical devices
UID:CAL-8a00ec8b-979413b9-0199-bef695a3-000070fbdemobedework@mysite.edu
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 er/Lectures_Conferences/Lecture_Talk
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi
 c-user/Topics/Natural Sciences
X-BEDEWORK-SPEAKER:Kacey Godwin
X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che
 m Admin Office
X-BEDEWORK-IMAGE-X1:85
X-BEDEWORK-IMAGE-Y1:0
X-BEDEWORK-IMAGE-X2:1705
X-BEDEWORK-IMAGE-Y2:1080
X-BEDEWORK-IMAGE-CROP-WIDTH:1620
X-BEDEWORK-IMAGE-CROP-HEIGHT:1080
X-BEDEWORK-IMAGE-ALT-TEXT:KG
X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry
 )
X-BEDEWORK-IMAGE:/public/Images/30_20251007015734PM.jpg
X-BEDEWORK-THUMB-IMAGE:/public/Images/30_20251007015734PM-thumb.png
END:VEVENT
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