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BEGIN:VEVENT

CATEGORIES:Natural Sciences
CATEGORIES:Lectures/Conferences
CATEGORIES:Utilities
CATEGORIES:Lecture/Talk
CATEGORIES:Main
CONTACT;X-BEDEWORK-UID=00f1fcdb-0f068baf-010f-068baf83-00000004:None
CREATED:20251022T155154Z
DESCRIPTION:Development of DART (Drugs Acutely Restricted by Tethering) Pr
 obes for Targeting Opioid Receptors and Voltage-Gated Sodium Channels\n\n
 \n\nThe brain\, comprising billions of neurons and glial cells\, forms in
 tricate networks that coordinate diverse functions such as movement\, emo
 tion\, and memory through sophisticated communication systems. Assigning 
 functions to specific neuronal cell types is essential for understanding 
 underlying mechanisms but remains challenging with currently available to
 ols. The DART (Drugs Acutely Restricted by Tethering) system is a newly d
 eveloped approach that predominate over existing methods by uniquely enab
 ling spatiotemporal modulation of endogenous proteins with cell-type spec
 ificity. DART employs HaloTag protein (HTP)\, a self-labeling enzyme\, to
  achieve specificity through restricted expression in defined cell types.
  Its versatility has been demonstrated\, for example\, in delineating AMP
 AR-mediated motor control pathways in Parkinsonian mice. Building on this
  foundation\, the present work extends DART to opioid receptors (ORs) and
  voltage-gated sodium channels (Navs)\, both of which mediate essential f
 unctions but remain incompletely understood.\n\nThis dissertation focuses
  on developing DART probes targeting OR subtypes and Navs to define their
  specific roles\, such as pain processing and reward regulation for ORs\,
  and excitability and pathological states such as epilepsy for Navs. Guid
 ed by X-ray crystal structures and docking studies\, we successfully deve
 loped subtype-selective OR-DART probes: naltrexone2DART.2 for μ-OR\, nalt
 rindole3DART.2 for δ-OR\, and benzamideDART.2 for κ-OR. In parallel\, we 
 generated potent Nav-DART probes\, JHNav2DART.2 and JHNav3DART.2\, which 
 effectively suppressed neuronal firing through cell-specific Navs modulat
 ion in cultured hippocampal neurons.\n\nWe anticipate that these newly de
 veloped probes\, efficient and subtype-selective OR-DART probes and poten
 t Nav-DART probes\, will serve as powerful tools for uncovering target-sp
 ecific neuronal functions that shape behavior via cell-specific modulatio
 n. Ultimately\, we expect that applying these probes within the DART plat
 form will expand and advance knowledge of the cell-specific roles of ORs 
 and Navs in both normal physiology and neurological disease.
DURATION:PT1H
DTSTAMP:20251022T155154Z
DTSTART;TZID=America/New_York:20251104T090000
LAST-MODIFIED:20251022T155154Z
LOCATION;X-BEDEWORK-UID=18832e99-2b52a4d8-012b-5382144d-00000090:French Fa
 mily Science Center 3232
STATUS:CONFIRMED
SUMMARY:Chemistry Defense: Yunju Oh: Development of DART (Drugs Acutely Re
 stricted by Tethering) Probes for Targeting Opioid Receptors and Voltage-
 Gated Sodium Channels
UID:CAL-8a00ec8b-979413b9-019a-0c9ea541-0000373ademobedework@mysite.edu
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili
 ties/Main
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Lecture_Talk:/user/public-us
 er/Lectures_Conferences/Lecture_Talk
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Natural Sciences:/user/publi
 c-user/Topics/Natural Sciences
X-BEDEWORK-SPEAKER:Yunju Oh
X-BEDEWORK-STUDENT-CONTACT;X-BEDEWORK-PARAM-EMAIL=chem-office@duke.edu:Che
 m Admin Office
X-BEDEWORK-IMAGE-X1:0
X-BEDEWORK-IMAGE-Y1:174
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X-BEDEWORK-IMAGE-CROP-HEIGHT:854
X-BEDEWORK-IMAGE-ALT-TEXT:YO
X-BEDEWORK-SUBMITTEDBY:lao26 for Chemistry (agrp_ArtsandSciences_Chemistry
 )
X-BEDEWORK-IMAGE:/public/Images/YO_20251022035154PM.jpg
X-BEDEWORK-THUMB-IMAGE:/public/Images/YO_20251022035154PM-thumb.png
END:VEVENT
END:VCALENDAR