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BEGIN:VEVENT

CATEGORIES:Lectures/Conferences
CATEGORIES:Utilities
CATEGORIES:Panel/Seminar/Colloquium
CATEGORIES:Main
CONTACT;X-BEDEWORK-UID=8a0183a7-83184018-0184-87170e31-00006277:Hinz\, Nic
 olle
CREATED:20260210T150049Z
DESCRIPTION:The mechanical properties of biological tissues change over ti
 me and with disease progression. Quantifying these mechanical properties 
 can thus be instrumental for medical diagnosis and for evaluation of tiss
 ue viability for transplant. However\, it is exceptionally challenging to
  mechanically characterize soft and biological materials using convention
 al testing methods\, especially in-vivo. In recent years\, volume control
 led cavity expansion (VCCE) has emerged as a powerful needle-based method
  for quantifying the nonlinear properties of soft materials in-situ. In t
 his talk\, after briefly revisiting the fundamentals of VCCE\, I will des
 cribe the translation of VCCE into Digital Palpation (DP)\; a minimally i
 nvasive diagnostic tool offering a quantitative alternative to a clinicia
 n's sense of touch. I will describe the application of DP for testing in 
 human tissue and will focus on an ex-vivo study of 35 tests in freshly re
 sected human thyroid nodules. I will show how data from this rapid and mi
 nimally invasive mechanical test enables separation between benign and ma
 lignant nodules of this highly prevalent cancer and can even hint at reso
 lving oncocytic and follicular sub-types that routinely confound existing
  diagnosis methods. At present\, up to one third of thyroid nodules canno
 t be decisively classified\, leading to avoidable surgical removal of the
  thyroid gland. We hope that these results can\, in the future\, help to 
 reduce the large fraction of thyroidectomies (40-70%) that ultimately pro
 ve benign and thus avoidable\; potentially relieving patients from the po
 tential life-long implications of surgical complications and hormone repl
 acement\, and paving the way for the diagnosis of additional diseases.
DURATION:PT1H
DTSTAMP:20260210T150049Z
DTSTART;TZID=America/New_York:20260217T120000
LAST-MODIFIED:20260210T150049Z
LOCATION;X-BEDEWORK-UID=2c918083-7c1b2592-017c-343e7a30-00001f55:Wilkinson
  Building\, room 021 auditorium
STATUS:CONFIRMED
SUMMARY:CEE Seminar - From Cavity Expansion to Clinical Diagnosis
UID:CAL-8a00eca5-9af98aae-019c-4811c23e-00007b09demobedework@mysite.edu
URL:http://cee.duke.edu
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Main:/user/public-user/Utili
 ties/Main
X-BEDEWORK-ALIAS;X-BEDEWORK-PARAM-DISPLAYNAME=Panel_Seminar_Colloquium:/us
 er/public-user/Lectures_Conferences/Panel_Seminar_Colloquium
X-BEDEWORK-SPEAKER:Dr. Tal Cohen Department of Civil &  Environmental Engi
 neering\, MIT Department of Mechanical  Engineering\, MIT
X-BEDEWORK-DUKE-SERIES:CEE Spring Seminar Series 2026
X-BEDEWORK-SUBMITTEDBY:nh143 for Civil and Environmental Engineering (CEE)
  (agrp_PrattSchool_CEE)
END:VEVENT
END:VCALENDAR