BioE Seminar: Overcoming Transport Barriers in the Tumor Microenvironment to Enchance cancer Immunotherapy

Abstract: The transport of fluids, biomolecules and cells from the tumor microenvironment to draining lymph nodes and into the circulation is facilitated by the concerted influence of the blood and lymphatic vascular systems. Our efforts to characterize the impact of these transport processes on disease progression, in particular by regulating both metastasis and adaptive immunity, as well as to develop novel therapeutic approaches for tumor therapy that mitigate these effects, will be described.