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Characterizing Exposure, Metabolism, and In Vitro effects of Azobenzene Disperse Dyes in the Indoor Environment

Headshot of Kirsten Overdahl, PhD candidate
Thursday, March 25, 2021
12:00 pm - 1:15 pm
Kirsten Overdahl, PhD Candidate, Duke University
Integrated Toxicology & Environmental Health Seminar Series

Azobenzene disperse dyes are the fastest-growing class of synthetic dyestuffs, and have recently been identified as the predominant class of brominated compounds in indoor house dust. Yet, little is known about dye sources, transformations, and health implications with regard to the indoor environment, particularly where children's health is concerned. Numerous studies have suggested that these compounds and their breakdown products are likely immune sensitizers, among other toxicological concerns. Using high resolution mass spectrometry, cheminformatic methods, and in vitro models, we investigated the occurrences of azobenzene disperse dyes in children's clothing and in indoor house dust, explored the haptenic potential of these compounds to engage in immune sensitization, and characterized the metabolites of these compounds.

Live Zoom presentation. Register to receive Zoom link at: https://duke.zoom.us/meeting/register/tJArdOmurjIuG9fQglBsNt2pzhguWVSueX9X

Contact: Alexis Sharp