BioE Seminar: Leveraging the Natural Cellular and Biomolecular Interactions in Blood for Design of Targeted, Anti-Inflammatory Particle Therapeutics

Localized delivery of therapeutics offers the possibility of increased drug effectiveness while minimizing side effects often associated with systemic drug administration. Our work focuses on probing the role of particle geometry, material chemistry, and blood rheology/dynamics on the ability of vascular-targeted drug carriers to interact with the blood vessel wall - an important consideration that will control the effectiveness of drug targeting regardless of the targeted disease or delivered therapeutically. This presentation will highlight the carrier-blood cell interactions that affect drug carrier binding to the vascular wall and alter critical neutrophil functions in disease. The talk will present the material design parameters for optimal drug carriers' design for active and passive use in treating many inflammatory diseases, including acute neutrophilic injury diseases.

Email Michael Humphreys (michael.humphreys@duke.edu) for Zoom information.