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BioE Seminar: Biomaterials for Modeling and Repairing Heterogeneous Tissue Microenvironments

Steven Caliari PhD
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Thursday, November 19, 2020
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12:00 pm - 1:00 pm
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Steven Caliari, Ph.D., Assistant Professor, Departments of Chemical Engineering and Biomedical Engineering, University of Virginia

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Tissue microenvironments are heterogeneous at both the cellular and extracellular levels. Recent advances in the design of tissue-mimicking biomaterials are increasingly moving away from static, monolithic platforms and toward dynamic, interactive, and responsive materials that capture the complexity of native cellular microenvironments in wound healing and tissue regeneration. My group engineers instructive biomaterials to tackle human health challenges including treatment of fibrotic disease and repair of injured tissues. In this talk I will discuss our progress on creating hydrogel disease models that capture the spatiotemporally dynamic mechanics of fibrosis as well as designing biomaterial scaffolds for skeletal muscle and muscle-tendon junction tissue engineering.