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"Modulating the conformation and function of disease-relevant RNA with small molecules": A Chemistry Faculty Colloquium Presented by Prof. Amanda Hargrove

Prof. Amanda Hargrove
Friday, October 07, 2022
3:00 pm - 4:00 pm
Prof. Amanda Hargrove
Chemistry Faculty Colloquium

"Modulating the conformation and function of disease-relevant RNA with small molecules"

The Hargrove lab harnesses the unique properties of small organic molecules to study the structure, function and therapeutic potential of long noncoding RNAs (lncRNAs).

The discovery of these fascinating biomolecules has caused a paradigm shift in molecular biology and speculation as to their role as the master drivers of diseases such as cancer. At the same time very little is known about their structure and function, leading some to call the field a veritable "Wild West."

Small molecules are the perfect tools for such exploration, and the Hargrove lab works at the interface of chemistry and biology, employing methods ranging from RNA-targeted small molecule synthesis and array-based pattern recognition to studies of the molecular and cellular biology of nucleic acids.