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Mechanistic understanding of ultrafine carbon and ozone mixed inhalation exposures induced lung toxicity

Formal headshot of seminar speaker, Dr. Salik Hussain, wearing a navy blue suit and tie in front of a light gray background
Friday, October 14, 2022
12:00 pm - 1:15 pm
Salik Hussain, DVM, PhD, West Virginia University
Integrated Toxicology & Environmental Health Seminar Series

Environmental inhalation exposures are inherently mixed (gases and particles), yet regulations are still based on single toxicant exposures. While the impacts of individual components of environmental pollution have received substantial attention, the impact of inhalation co-exposures is poorly understood. Characterization of ozone aggravated oxidant generation abilities of carbon particles using electron paramagnetic resonance will be presented. Moreover, transcriptomic, biochemical, physiological and cellular/molecular evidence of enhanced biological activity of co-exposure aerosols will be presented. In addition, novel findings on co-exposure induced altered lung remodeling in an acute lung injury and contribution of Nod like receptor X1 will be presented.

THIS IS A HYBRID SEMINAR: LIVE IN-PERSON & VIA ZOOM:
-IN-PERSON: Field Auditorium (room 1112), Grainger Hall (9 Circuit Dr, Durham). Masks are required.
-ZOOM: Must register for link: https://duke.zoom.us/meeting/register/tJAuceqtpz8qHd2ymSuqpTjyQ9iwZvySLN3M
-Both attendance options are free and open to all.

Contact: Alexis Sharp