BioE Seminar: Engineering Human Microvasculature in Inflammatory and Fibrotic Disease
Abstract: Microvascular dysfunction and disintegration is key to the genesis and progression of many diseases of capillary rich organs. Such organs include skin, kidney, heart and lungs, each abundant in microvasculature, and enriched in microvascular mural cells known as pericytes. The pericyte-elaborated basement membrane, while considered an important regulator of microvascular stability, has been inadequately characterized in the healthy, inflamed or fibrotic state. Further, in vivo systems have demonstrated that pericytes are capable of vascular destabilization and migration for the microvessel into the interstitial tissue during fibrosis, though mechanisms driving this activity have not been well elucidated.