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Persistent mitochondrial effects of early-life arsenic exposure in C. elegans

Headshot of Kathleen Hershberger, PhD
Thursday, January 14, 2021
12:00 pm - 1:15 pm
Kathleen Hershberger, PhD, Grinnell College
Integrated Toxicology & Environmental Health Seminar Series

Arsenic is a well-established environmental toxicant that contributes to the pathogenesis of a number of diseases including cardiomyopathy, neuropathy, and cancers. Carcinogenic effects may be regulated via epigenetic mechanisms, suggesting that effects of arsenic exposure may persist through multiple generations. Arsenic inhibits a number of enzymes in energy production that results in metabolic shifts that support disease pathogenesis, making mitochondria an important target of arsenic toxicity to further study. In this seminar, Dr. Hershberger will summarize her work using C. elegans to study the transgenerational and persistent effects of early-life arsenic exposure.

Live Zoom presentation. Register to receive Zoom link at: https://duke.zoom.us/meeting/register/tJArdOmurjIuG9fQglBsNt2pzhguWVSueX9X

Contact: Alexis Sharp