Genetic and epigenetic factors that mitigate H2S toxicity in metazoans

Hydrogen sulfide (H2S) is a toxic gas that is a common environmental and industrial toxin. H2S is also produced endogenously, and is an important cellular signaling molecule. Treatment with exogenous H2S can protect mammals against cell damage and death from ischemia/reperfusion. The mechanism of H2S toxicity is poorly understood, and there is little known about the relationship between beneficial and toxic effects of H2S. We use the nematode, C. elegans, to explore genetic factors that mediate H2S signaling and toxicity in animals.

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