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Ruth K. Broad Seminar

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Tuesday, November 03, 2020
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12:00 pm - 1:00 pm
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Jennifer Lippincott-Schwartz, hosted by Cagla Eroglu
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The Ruth K. Broad Foundation Seminar Series on Neurobiology and Disease

Duke Neurobiology welcomes Jennifer Lippincott-Schwartz, PhD, Senior Group Leader at HHMI's Janelia Research Campus, to give her talk "Eukaryotic organelles: deciphering their interdependency, structure and dynamics with new imaging technologies."
For connection info to her Zoom seminar, email d.shipman@duke.edu.
Abstract: Powerful new ways to image the internal structures and complex dynamics of cells are revolutionizing cell biology and bio-medical research. In this talk, I will focus on how emerging fluorescent technologies are increasing spatio-temporal resolution dramatically, permitting simultaneous multispectral imaging of multiple cellular components. In addition, results will be discussed from whole cell milling using Focused Ion Beam Electron Microscopy (FIB-SEM), which reconstructs the entire cell volume at 4 voxel resolution. Using these tools, it is now possible to begin constructing an "organelle interactome", describing the interrelationships of different cellular organelles as they carry out critical functions. The same tools are also revealing new properties of organelles and their trafficking pathways, and how disruptions of their normal functions due to genetic mutations may contribute to important diseases.