Sex chromosomes, sex hormones and sex differences in drug vulnerability
I was originally trained as a comparative behavioral neuroendocrinologist and over my career I have worked with several species of birds and mammals. For the past 15 years my main interests have been in understanding how estrogens modulate sex differences in the brain and behavior. I have a long standing interest in both endogenous estrogens and environmental estrogens, this ultimate triggered my work on Bisphenol A. In recent years I have also been asking how genes on the sex chromosomes also affect behavior, and as part of those studies I have gotten involved in epigenetics. This interest drove our current work on epigenetic inheritance and how environmental-induced modifications can be inherited transgenerationally. My lab been involved in behavioral phenotyping for several novel mouse models including the ERbeta KO mice and the four core genotype (FCG) mice. We have developed a large repertoire of behavioral skills and at the present time most of our work is on juvenile social and cognitive behavior. We also have mastered many basic and advanced molecular techniques. We genotype all the mice in our colonies with PCR. We measure protein with immunoblotting and via immunocytochemistry. We examine mRNA with in situ hybridization, real time qPCR, ChIP-PCR, bisulfite sequencing, and gene expression arrays. My lab has a long history of continuous funding from NIH and a strong record of training of Ph.D. and post-doctoral students for successful careers in academic research.
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