Chemistry Seminar: Mechanistic studies and potential application of non-heme iron enzymes in natural product biosynthesis

Host: Dr Ken Yokoyama, Ph.D

Metalloenzymes catalyze a broad array of oxidative modifications that are involved in primary metabolism as well as natural product biosynthesis. Among diverse reaction types, C-N bond and C-C bond installation catalyzed by several iron and 2-oxoglutarate dependent enzymes represent novel transformations found in natural product biosynthetic pathways. Herein, a combinatorial approach is used to demystify the plausible reaction mechanisms. Furthermore, the insight obtained through mechanistic investigation leads to the discovery of repurposing these enzymes for the preparation of useful small molecules.

https://duke.zoom.us/j/93224424080?pwd=V3JUWU9mVnhUbTZpeTZTN1ExZE9vQT09
Meeting ID: 932 2442 4080
Password: 546621