Skip to main content
Browse by:
GROUP

Effective March 10, 2020, all Duke-sponsored events over 50 people have been cancelled, rescheduled, postponed or virtualized.
Please check with the event contact regarding event status. For more information, please see https://coronavirus.duke.edu/events

The Ruth K. Broad Foundation Seminar Series on Neurobiology and Disease

Haruo Kasai headshot
Icon calendar
Tuesday, February 11, 2020
Icon time
12:00 pm - 1:00 pm
Icon speaker
Haruo Kasai; hosted by Jim McNamara
Icon series
The Ruth K. Broad Foundation Seminar Series on Neurobiology and Disease

Duke Neurobiology welcomes Haruo Kasai, MD, PhD, from the University of Tokyo to present his talk "Mechanical and dopamine actions on dendritic-spine synapses and psychiatric disorders." Abstract: Neuronal circuits made by synapses in the brain enable learning, memory, perception, emotion, and their impairment results in various mental disorders. We perform research that extensively utilize microscopic methods to observe cellular and molecular events deep within the brain, and which allow labeling of potentiated synapses and optical manipulation of synapses and circuits. We have shown that cerebral spine synapses undergo rapid enlargement during potentiation in the hippocampus, neocortex and basal ganglia. Such dynamic synaptic motilities are the sites of endogenous neuromodulation, therapeutic agents and addictive drugs. Moreover, the dynamic nature of synapses has allowed us to construct new optical and molecular probes for a better understanding of learning and cognition and their impairments.