Myelination in the CNS: Intrinsic and extrinsic regulation

Myelination is vital for the rapid and energy-efficient propagation of action potentials in the vertebrate nervous system, but what regulates the development of oligodendrocytes and their decision of which axons to myelinate? Our lab uses genome-wide expression analyses, tissue culture, mouse genetic models and viral approaches to investigate the cellular and molecular mechanisms that regulate CNS myelination in development, injury and plasticity.