Cell-autonomous obesity due to loss of ankyrin-B function

The Lorenzo lab investigates the role played by cytoskeletal proteins in maintaining cellular homeostasis and the mechanistic basis of cytoskeleton-associated neurological, metabolic, and muscular disorders. We seek to understand how the assembly and dynamic coordination of cytoskeletal networks in specialized cell types contribute to the regulation of signal transduction, intracellular trafficking, cell motility, membrane dynamics, and cellular metabolism. We are currently studying the neurobiological and metabolic roles of ankyrins, spectrins, and associated partners.