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CANCELLED - Systems toxicology and One Health metabolic disorders

Seminar speaker, Augustine Arukwe, in a suit and tie, smiling
Thursday, February 13, 2025
12:00 pm - 1:15 pm
Augustine Arukwe, DSc, Norwegian University of Science & Technology
Integrated Toxicology & Environmental Health Seminar Series

2/11/20025 Update: This seminar has been CANCELLED.
Several animal studies have produced an increasing amount of evidence suggesting that continued exposure to contaminants with endocrine-disrupting potentials (endocrine-disrupting chemicals, EDCs) contribute to the increased prevalence of metabolic disorders in wildlife species and humans. The environmental obesogenic hypothesis was proposed to explain the involvement of environmental contaminants that can disrupt normal development and control of adipogenesis and energy balance. Increase in adipocyte number and lipid content are required for the progression to obesity, and transcriptional master regulators are critical to the regulation of gene networks that control intracellular lipid homeostasis, adipocyte proliferation and differentiation. While there are few studies on molecular and cellular mechanisms that underly the obesogen-related metabolic disorders, the systems toxicological understanding of these processes under a one health network has not been fully explored. In this presentation, I will use two animal models (fish and rodents) as proxies for different taxa and humans in explaining the role(s) played by environmental contaminants in the prevalence of metabolic disorders. The application of one health and systems toxicology in understanding toxicological mode-of-action and associated adverse outcomes, requires a multidisciplinary approach, where omics technologies is in harmony with molecular and cell biology, physiology, pathology, marine science, environmental chemistry, ecology, as well as computational biology.

THIS IS A REMOTE SEMINAR ONLY
This seminar will be held via Zoom
The speaker will present virtually.
Visit the seminar website to register for the Zoom link.