Leveraging zebrafish as a model to study maternal-to-zygotic transition and dorsoventral patterning as targets of developmental toxicants

In this presentation, Dr. Dasgupta will talk about part of the research going on in his lab for the past 1.5 years, studying impacts of flame retardant tetrabromobisphenol A (TBBPA) on early development, using zebrafish as a model. His lab's studies show that TBBPA exposures result in pre-pluripotent developmental delays and subsequent disruption of dorsoventral patterning- an event that establishes the embryonic axis. The talk will cover his lab's work encompassing TBBPA-induced impacts on maternal-to-zygotic transition and their efforts to interrogate the role of histone acetylation and P300 histone acetyltransferase protein as a primary target of TBBPA and developmental delays. The talk will also cover studies on dorsoventral patterning, interrogating the modes of action driving TBBPA-induced "ventralization" phenotypes. He will specifically talk about bone morphogenetic protein signaling as well as transcription factors and cell adhesion proteins involved in epithelial-to-mesenchymal transition as specific targets of TBBPA across developmental time points.

THIS IS A HYBRID SEMINAR: In person and online via Panopto
This seminar will be held in Grainger Hall room 1112.
Visit the seminar website for a link to attend virtually.
Both attendance options are free and open to all.