Deciphering Odor Recognition

Our lab primarily focuses on mammalian olfaction, pioneering the functional elucidation of odorant receptors. Our work includes large-scale characterization of odorant receptors and investigating human genetic variations affecting odor perception. We have developed RNA sequencing-based techniques for identifying activated odorant receptors in behaving mice. Recently, we contributed in resolving the first atomic structure of a mammalian odorant receptor, advancing understanding of odorant binding and activation mechanisms.