Air Pollution and Susceptible Populations

Particulate matter (PM), a major component of ambient air pollution, accounts for a substantial burden of diseases and death worldwide. Maternal exposure to PM during pregnancy is particularly harmful to children's health since this is a phase of rapid human growth and development. In this seminar, I will highlight recent findings from our mouse model of prenatal ultrafine particle (UFP) exposure. Our findings demonstrate in utero UFP exposure leads to dysregulated bile acid/lipid homeostasis through increased FXR expression in placenta and fetal lung tissue, augmented in female offspring. Disruption of the Nrf2 antioxidant signaling pathway further exacerbates effects. Alterations in placental develop may play a role in long-term consequences on offspring metabolic and pulmonary health. Overall, policies to reduce maternal exposure and health consequences in children should be a high priority. Keywords: Air pollution, particulate matter, ultrafine particles, prenatal exposure, children's environmental health, placenta development, NRF2, oxidative stress.

THIS IS A HYBRID SEMINAR WITH IN-PERSON & REMOTE ATTENDANCE OPTIONS.
This seminar will be held in Field Auditorium (room 1112), Grainger Hall.
Visit the seminar website for a livestream link to tune in virtually.
Both attendance options (in person and virtual) are free and open to all.