Pathology Grand Rounds - Novel Non-replacement Therapies for Hemophilia. They Work in Patients, but Do They Work in Our Laboratory Assays?

At the conclusion of this activity, learners should be able to:

* Understand the role of cell surfaces and plasma protease inhibitors in regulating the process of hemostasis

* Appreciate how altering the levels of protease inhibitors can be used to "rebalance" and improve hemostasis in hemophilia

* Appreciate the difficulties in monitoring non-replacement therapies in the clinical laboratory

* Understand how secondary protease inhibitors can maintain regulation of coagulation when the level of anti-thrombin is lowered to enhance hemostasis in hemophilia