The Evolution of Genome Evolution and Virulence in the Human Pathogen Histoplasma

Dr. Matute uses evolutionary principles to understand the biology of emerging fungal pathogens. These pathogens cause disease in over one billion people each year, and their impact is expanding as antifungal resistance becomes increasingly widespread. The Matute lab is currently focused on understanding the evolution of virulence in pathogens of the genus Histoplasma using computational genetics, in vitro evolution, and genetic modification.