Charting the future of RNA and protein sequence-structure exploration

"Charting the future of RNA and protein sequence-structure exploration"

RNA and protein sequences dictate their structures, spanning multiple length scales, from molecular conformations to patterns of subcellular localization. In turn, these structures govern biological function. Characterizing sequence-structure relationships is critical for gaining mechanistic understanding, but conventional techniques can be slow and low-throughput. We have developed integrated computational and experimental methods to overcome these limitations and applied them to resolve three-dimensional structures of a wide array of RNAs and RNA-protein complexes, and to systematically reveal the protein sequence features that drive condensate formation in cells. This work paves the way for the development of transformative predictive models of sequence-structure relationships.

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